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公开(公告)号：US20060147996A1
公开(公告)日：2006-07-06
申请号：US11284469
申请日：2005-11-22
申请人： Thomas Ullrich , Torsten Schulz , Thomas Ellinger , Siegfried Poser , Eugen Ermantraut , Ralf Ehricht
发明人： Thomas Ullrich , Torsten Schulz , Thomas Ellinger , Siegfried Poser , Eugen Ermantraut , Ralf Ehricht
CPC分类号： C12Q1/686 , B01J19/0046 , B01J2219/00457 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01L3/5082 , B01L9/52 , B01L2200/025 , B01L2300/0609 , B01L2300/0636 , C12Q1/6837 , C40B40/06 , C40B40/10 , C12Q2537/162 , C12Q2537/161 , C12Q2531/107 , C12Q2525/186
摘要： The invention relates to a holding device for substance libraries which can be used, more particularly, for the detection of target molecules with the aid of substance libraries. Said device comprises: (i) a holder for a substance library carrier; (ii) a substance library carrier, which can be fixed to the holder; and (iii) a detection area applied to the substance library carrier, whereon a substance library is immobilized; and wherein at least one substance library carrier can be introduced into a laboratory reaction vessel.
摘要翻译： 本发明涉及用于物质文库的保持装置，更具体地说，可用于借助物质文库检测靶分子。 所述装置包括：（i）用于物质库载体的保持器; （ii）可以固定在保持器上的物质库载体; 和（iii）应用于物质文库载体的检测区域，其中固定有物质文库; 并且其中可以将至少一种物质文库载体引入实验室反应容器中。
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公开(公告)号：US09891226B2
公开(公告)日：2018-02-13
申请号：US14564067
申请日：2014-12-08
申请人： Eugen Ermantraut , Thomas Kaiser , Jens Tuchscheerer , Vico Baier , Torsten Schulz , Anke Wostemeyer
发明人： Eugen Ermantraut , Thomas Kaiser , Jens Tuchscheerer , Vico Baier , Torsten Schulz , Anke Wostemeyer
CPC分类号： G01N33/58 , B01L3/50273 , B01L2200/025 , B01L2200/0684 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , Y10T436/25
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
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公开(公告)号：US09731292B2
公开(公告)日：2017-08-15
申请号：US13597012
申请日：2012-08-28
CPC分类号： B01L3/502707 , B01L2300/0636 , B01L2300/069 , B01L2300/0877 , B01L2400/0481 , C12Q1/6834
摘要： The present invention relates to devices and methods for performing assays, especially for determining the presence and/or amount of one or more analytes. In particular, the invention relates to a device for the detection of analytes, comprising a reversibly compressible matrix located between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and wherein the distance between the first surface and the second surface is variable. The invention also relates to a corresponding method using such a device for the detection of one or more species of analytes.
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公开(公告)号：US08633013B2
公开(公告)日：2014-01-21
申请号：US12451243
申请日：2008-05-05
申请人： Thomas Kaiser , Klaus-Peter Möbius , Torsten Schulz , Thomas Uhlig , Alexander Von Schenk Zu Schweinsberg , Eugen Ermantraut , Jens Tuchscheerer
发明人： Thomas Kaiser , Klaus-Peter Möbius , Torsten Schulz , Thomas Uhlig , Alexander Von Schenk Zu Schweinsberg , Eugen Ermantraut , Jens Tuchscheerer
IPC分类号： C12M1/34
CPC分类号： B01L3/50273 , B01L3/502715 , B01L3/502738 , B01L2300/0636 , B01L2300/0816 , B01L2300/123 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.
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公开(公告)号：US20120088252A1
公开(公告)日：2012-04-12
申请号：US13274175
申请日：2011-10-14
IPC分类号： G01N21/75
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.
摘要翻译： 本发明涉及用于定性和/或定量检测颗粒的装置和方法。 特别地，本发明涉及用于检测颗粒的装置，其包括形成在第一表面和第二表面之间的室主体内的反应室，其中第二表面位于与第一表面相对的位置，以及一个或多个位移器， 其中所述第一表面和所述第二表面之间的距离可经由所述一个或多个置换器在所述第一表面和/或第二表面的表面区域的至少一个或多个部分中是可变的。 本发明还涉及用于检测颗粒的相应方法。
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公开(公告)号：USD629907S1
公开(公告)日：2010-12-28
申请号：US29337653
申请日：2009-05-27
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公开(公告)号：US20100255473A1
公开(公告)日：2010-10-07
申请号：US12670088
申请日：2008-07-23
IPC分类号： C12Q1/68
CPC分类号： B01L3/502738 , B01L3/5027 , B01L2300/0816 , B01L2300/0887 , B01L2300/18 , B01L2400/0415 , B01L2400/0481 , B01L2400/0655 , C12Q1/6816 , C12Q1/6848 , C12Q1/703 , C12Q1/708 , C12Q2521/107 , C12Q2531/113 , C12Q2547/101 , C12Q2563/107 , C12Q2563/149 , C12Q2565/601 , C12Q2565/629
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，以及用于确定指示靶分子的存在和/或量的值;互连的微流体网络 至少第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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48.发明申请Dispenser device for and a method of dispensing a substance onto a substrate 审中-公开用于将物质分配到基底上的分配器装置和方法公开(公告)号：US20100092683A1
公开(公告)日：2010-04-15
申请号：US12442471
申请日：2007-09-24
申请人： Eugen Ermantraut , Torsten Schulz , Jaochim Fischer , Daniel Weicherding , Siegfried Poser , Matthias Kirst
发明人： Eugen Ermantraut , Torsten Schulz , Jaochim Fischer , Daniel Weicherding , Siegfried Poser , Matthias Kirst
CPC分类号： G01N35/1011 , G01N35/028 , G01N35/109 , G01N2001/4027 , G01N2035/00158 , G01N2035/1037 , G01N2035/1039
摘要： A dispenser device (100) for dispensing a substance (101) onto a substrate (102), the dispenser device (100) comprising a gripper unit (103) adapted for gripping a container (104) including the substance (101), a first motion mechanism (116, 117) adapted for moving the gripper unit (103) and the substrate (102) relative to each other within a planar region (106), and a second motion mechanism (115, 201 and 209) adapted for moving the gripper unit (103) and the substrate (102) relative to each other in a direction (108) essentially perpendicular to the planar region (106) to thereby dispense the substance (101) to a surface portion (109) of the substrate (102), wherein the first motion mechanism (115) and the second motion mechanism (116, 117) are decoupled from one another.
摘要翻译： 一种用于将物质（101）分配到基底（102）上的分配器装置（100），所述分配器装置（100）包括适于夹持包括所述物质（101）的容器（104）的夹持器单元（103），第一 适于在平面区域（106）内相对于彼此移动所述夹持单元（103）和所述基板（102）的运动机构（116,117）以及适于移动所述夹持单元 夹持器单元（103）和基板（102）在基本上垂直于平面区域（106）的方向（108）上相对于彼此分配，从而将物质（101）分配到基板（102）的表面部分（109） ），其中所述第一运动机构（115）和所述第二运动机构（116,117）彼此分离。
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公开(公告)号：US20090082219A1
公开(公告)日：2009-03-26
申请号：US12092643
申请日：2006-11-06
申请人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
发明人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
摘要翻译： 本发明涉及用于检测分析物的装置和方法。 特别地，本发明涉及用于定性和/或定量检测分析物的方法，其包括在基底上的微阵列，探针分子固定在阵列元件上，所述微阵列设置在装置的第一表面上; 以及检测室，形成在包括设置在其上的微阵列的第一表面和第二表面之间，其中微阵列和第二表面之间的距离是可变的，并且其中第二表面具有位移结构。
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公开(公告)号：US20080207461A1
公开(公告)日：2008-08-28
申请号：US11667118
申请日：2005-11-09
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00662 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01L3/5085 , G01N35/00029 , G01N35/028 , G01N2035/00158
摘要： The present invention relates to devices for the simultaneous performance of microarray experiments for detecting specific interactions between probe and target molecules in a microtiter plate as well as to methods for manufacturing such devices. Furthermore, the present invention relates to the use of such devices in a method for qualitatively and/or quantitatively detecting specific interactions between probe and target molecules.
摘要翻译： 本发明涉及用于同时执行用于检测微量滴定板中的探针和靶分子之间的特异性相互作用的微阵列实验的装置以及用于制造这种装置的方法。 此外，本发明涉及在定性和/或定量检测探针和靶分子之间的特异性相互作用的方法中使用这种装置。
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