公开(公告)号：US20040023913A1

公开(公告)日：2004-02-05

申请号：US10399048

申请日：2003-04-18

发明人： Hans-Juergen Neumann ,  Helmut Knoller

IPC分类号： A61K048/00 ,  C07H021/02

CPC分类号： C07D219/12 ,  C07D475/14

摘要： The invention relates to a pathogen-inactivating agent, as well as its use, whereby the agent contains an element that binds to nucleic acids of the pathogens, and a conjungate that destroys nucleic acid. The conjungate is created from a metal chelate complex, in which the metal can change between at least two oxidation levels. In particular, the agent can be used in physiological liquids, such as blood, or blood fractions for the inactivation of viruses.

摘要翻译： 本发明涉及病原体灭活剂及其用途，其中该试剂含有与病原体的核酸结合的元件，以及破坏核酸的结合物。 金属螯合物由金属螯合物形成，其中金属可以在至少两个氧化水平之间变化。 特别地，该药剂可以用于生理液体，如血液或血液部分，用于灭活病毒。

公开(公告)号：US20040006028A1

公开(公告)日：2004-01-08

申请号：US10436401

申请日：2003-05-12

发明人： Matthew S. Platz

IPC分类号： A61K031/7056 ,  A61K031/525

CPC分类号： C07D475/14 ,  A61K31/525 ,  A61K31/7056 ,  A61K41/00 ,  A61K41/0019 ,  A61K41/0038 ,  A61K45/06 ,  A61K2300/00

摘要： Compounds comprising flavin N-oxides for treatments of solid tumors, non-solid tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods of treating patients having solid type cancers comprising administering a therapeutically effective amount of a flavin N-oxide to a subject in need of treatment and exposing the flavin N-oxide to an activator such that activation of the flavin N-oxide results in damage to the DNA in the cancer cells without substantial damage to the DNA of normal cells are also provided. Methods of using a flavin N-oxide as part of a combination therapy with chemotherapy, radiation therapy, or both are also provided. Methods of reducing pathogenic bacterial or viral contamination in a composition comprising a) mixing the composition with an efficacious amount of a flavin N-oxide and b) exposing the mixture of the composition and the flavin N-oxide to an activator for a period of time sufficient to activate the flavin N-oxide such that the flavin N-oxide reduces the contamination in the composition are also provided. Preferably, the composition is a blood product selected from plasma, platelets, and red blood cells and the activator is an enzyme.

摘要翻译： 包含用于治疗实体瘤，非固体肿瘤块，白血病和非小细胞肺癌的黄素N-氧化物的化合物和用于消除血液制品中的污染物。 治疗患有固体型癌症的患者的方法包括向需要治疗的受试者施用治疗有效量的黄素N-氧化物，并将黄素N-氧化物暴露于活化剂，使得黄素N-氧化物的活化导致对 还提供了对正常细胞的DNA没有显着损伤的癌细胞中的DNA。 还提供了使用黄素N-氧化物作为化疗，放射治疗或两者的组合疗法的一部分的方法。 减少组合物中病原菌或病毒污染的方法，包括：a）将组合物与有效量的黄素N-氧化物混合，和b）将组合物和黄素N-氧化物的混合物暴露于活化剂一段时间 足以活化黄素N-氧化物，使得黄素N-氧化物减少组合物中的污染物也被提供。 优选地，组合物是选自血浆，血小板和红细胞的血液制品，并且活化剂是酶。

公开(公告)号：US20010024781A1

公开(公告)日：2001-09-27

申请号：US09777727

申请日：2001-02-05

发明人： Matthew Stewart Platz ,  Raymond Paul Goodrich JR.

IPC分类号： A61K031/495 ,  C07D239/70

CPC分类号： A61L2/0076 ,  A61L2/0088 ,  A61L2/10 ,  A61L2202/22 ,  C07D475/14

摘要： Methods are provided for neutralization of microorganisms in fluids or on surfaces. Preferably the fluids contain blood or blood products and comprise biologically active proteins. Preferred methods include the steps of adding an activation-effective amount of a microorganism neutralizer with an isoalloxazine backbone to a fluid and exposing the fluid to a triggering event. Preferred triggering events include light of a suitable wavelength and intensity to activate the microorganism neutralizer or a pH sufficient to activate the microorganism neutralizer. Other fluids, including juices, water and the like, may also be decontaminated by these methods as may surfaces of foods, animal carcasses, wounds, food preparation surfaces and bathing and washing vessel surfaces. Compounds with an isoalloxazine backbone are also provided.

公开(公告)号：US6150364A

公开(公告)日：2000-11-21

申请号：US420824

申请日：1999-10-19

申请人： Gerhard Wagner

发明人： Gerhard Wagner

IPC分类号： C07B63/00 ,  A61K31/519 ,  A61K31/525 ,  C07D475/14

CPC分类号： C07D475/14

摘要： Purified and crystallized riboflavin is prepared by a process that includes dissolving needle-shaped riboflavin of the stable modification A form in an aqueous mineral acid solution at a temperature not exceeding about 30.degree. C. with intensive intermixing. Active charcoal is then added to the resulting solution. After adsorption of the dissolved impurities from the solution onto the active charcoal, the solution containing the active charcoal is subjected to counter-current filtration over a ceramic membrane having a pore size of about 20 to about 200 nm. The resulting filtrate is treated with a five- to ten-fold amount of water (vol./vol.) at a temperature not exceeding about 30.degree. C. The resulting precipitated, spherical crystals of riboflavin are then separated by centrifugation or filtration. If desired, the spherical crystals of riboflavin may be washed with water and subsequently dried. The purified and crystallized riboflavin formed by this process is suitable for pharmaceutical and foodstuff applications.

摘要翻译： 纯化和结晶的核黄素通过包括将稳定的修饰A形式的针状核黄素溶解在无机酸水溶液中，在不超过约30℃的温度下进行密集混合的方法来制备。 然后将活性炭加入到生成的溶液中。 将溶解的杂质从溶液中吸附到活性炭上之后，将含有活性炭的溶液在孔径为约20至约200nm的陶瓷膜上进行逆流过滤。 所得滤液在不超过约30℃的温度下用5至10倍量的水（体积/体积）处理。然后通过离心或过滤分离产生的沉淀的核黄素球形晶体。 如果需要，可以用水洗涤核黄素的球形晶体，随后干燥。 通过该方法形成的纯化和结晶的核黄素适用于药物和食品应用。

公开(公告)号：US4965133A

公开(公告)日：1990-10-23

申请号：US444946

申请日：1989-12-04

申请人： Satoshi Ueyama ,  Satoru Isoda

发明人： Satoshi Ueyama ,  Satoru Isoda

IPC分类号： C07D475/14 ,  C25B3/04 ,  C25B11/04

CPC分类号： C07D475/14 ,  Y10T428/31504

摘要： A modifying agent for a conductive substrate comprises a flavin derivative. A flavin-modified electrode obtained through modification by the modifying agent is capable of reducing an electron transfer protein having a standard oxidation-reduction potential higher than, or on the positive side of, the standard oxidation-reduction potential of the flavin derivative but is incapable of oxidizing the electron transfer protein, and is therefor capable of controlling electron transport so that the electron transport takes place in only one direction. With this characteristic feature, the modified electrode is applicable to functional devices such as diodes, transistors and optical switch devices.

摘要翻译： 导电性基材用改性剂含有黄素衍生物。 通过改性剂改性获得的黄素改性电极能够还原具有比黄素衍生物的标准氧化还原电位高或者正侧的标准氧化还原电位的电子转移蛋白质，但是不能 氧化电子转移蛋白，并且能够控制电子传输，使得电子传输仅在一个方向上发生。 利用该特征，改性电极适用于诸如二极管，晶体管和光开关器件等功能器件。

公开(公告)号：US4656275A

公开(公告)日：1987-04-07

申请号：US730056

申请日：1985-05-03

申请人： Hansgeorg Ernst ,  Heinz Eckhardt ,  Joachim Paust

发明人： Hansgeorg Ernst ,  Heinz Eckhardt ,  Joachim Paust

IPC分类号： C07C67/00 ,  C07C241/00 ,  C07C245/08 ,  C07D475/14 ,  C07C107/06

CPC分类号： C07D475/14

摘要： An improved process for the preparation of riboflavin by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline derivative with barbituric acid in the presence of an acidic condensing agent in an organic solvent, wherein a 4,5-dimethyl-N-(D)-ribityl-2-(o-alkoxyphenylazo)-aniline of the formula IIa ##STR1## where R is alkyl of 1 to 4 carbon atoms, in particular methyl, is reacted with barbituric acid, as well as the novel intermediates of the formula IIa.

摘要翻译： 一种改进的制备核黄素的方法，其通过在酸性缩合剂存在下，在有机溶剂中使4,5-二甲基-N-（D） - 间苯基] -2-苯基偶氮苯胺衍生物与巴比妥酸缩合， 其中R是1至4个碳原子的烷基，特别是甲基的式IIa的（R） - （2-（O-）烷基-2-（邻 - 烷氧基苯基偶氮） - 苯胺其中R是与巴比妥酸反应， 以及式IIa的新型中间体。

公开(公告)号：US4360669A

公开(公告)日：1982-11-23

申请号：US286601

申请日：1981-07-24

申请人： Wolfram Schmidt ,  Joachim Paust ,  Axel Nurrenbach

发明人： Wolfram Schmidt ,  Joachim Paust ,  Axel Nurrenbach

IPC分类号： C07C67/00 ,  C07C215/10 ,  C07C241/00 ,  C07C245/08 ,  C07D475/14 ,  C07H1/00 ,  C07H1/06

CPC分类号： C07D475/14

摘要： A process for the preparation of N-(D)-ribityl-2-phenylazo-4,5-dimethylaniline (I), wherein1. in the case of pure or virtually pure (D)-ribose (III)(a) the latter is reacted with 3,4-dimethylnitrobenzene (IVa) or 3,4-dimethylaniline (IVb) and with hydrogen in the presence of a hydrogenation catalyst,(b) the resulting solution is reacted, in a conventional manner, with an acid phenyldiazonium salt solution (VI) and(c) the resulting product is isolated by crystallization, in a conventional manner, or2. in the case of crude ribose, ie. industrial mixtures of (D)-ribose and other sugars(a) the crude ribose is reacted with about equimolar amounts, based on III, of 3,4-dimethylaniline (IVb) and boric acid,(b) the boric acid ester of the Schiff base obtained from III and IVb is allowed to crystallize out and is separated off,(c) this ester is hydrogenated with hydrogen in the presence of a hydrogenation catalyst,(d) the solution is freed from catalyst and reacted, in a conventional manner, with an acid phenyldiazonium salt solution and(e) the resulting product I is isolated by crystallization in a conventional manner.

摘要翻译： 制备N-（D） - 基] -2-苯基偶氮基-4,5-二甲基苯胺（I）的方法，其中1.在纯的或几乎纯的（D） - 核糖（III）（a）的情况下， 后者与3,4-二甲基硝基苯（IVa）或3,4-二甲基苯胺（IVb）和氢气在氢化催化剂存在下反应，（b）所得溶液以常规方式与酸性苯基重氮 盐溶液（VI）和（c）通过以常规方式结晶分离得到的产物，或在粗核糖的情况下， （D） - 核糖和其他糖（a）的工业混合物（a）粗核糖基于III，3,4-二甲基苯胺（IVb）和硼酸，以（b）硼酸酯的大约等摩尔量反应 允许从III和IVb获得的席夫碱结晶出并分离出来，（c）在氢化催化剂存在下，用氢气氢化该酯，（d）将溶液除去催化剂并以常规方式反应 用酸性苯基重氮盐溶液和（e）所得到的产物I通过常规方式结晶分离。

公开(公告)号：US4165250A

公开(公告)日：1979-08-21

申请号：US850991

申请日：1977-11-14

申请人： Albert Epstein ,  Glen Graham ,  William A. Sklarz

发明人： Albert Epstein ,  Glen Graham ,  William A. Sklarz

IPC分类号： A23K1/16 ,  C07D475/14 ,  C12P25/00 ,  C12D5/04

CPC分类号： C07D475/14 ,  A23K20/174 ,  C12P25/00

摘要： Riboflavin is recovered from fermentation broth by diluting the broth with a predetermined quantity of water, centrifuging the diluted broth to form a sludge, resuspending the sludge with a predetermined quantity of water, and centrifuging the resuspended sludge to yield a product usuable directly as an animal feed supplement or suitable for further purification for pharmaceutical use. Optionally the broth or resuspended sludge is treated with an enzyme before centrifugation.

摘要翻译： 通过用预定量的水稀释培养液从发酵液中回收核黄素，将稀释的肉汤离心以形成污泥，用预定量的水重新悬浮污泥，并将再悬浮的污泥离心以产生直接作为动物使用的产品 饲料补充剂或适合用于药物用途的进一步纯化。 任选地，在离心之前用酶处理肉汤或再悬浮的污泥。

公开(公告)号：US3052668A

公开(公告)日：1962-09-04

申请号：US54185055

申请日：1955-10-20

申请人： NONED CORP

发明人： LAMBOOY JOHN P

IPC分类号： C07D475/14

CPC分类号： C07D475/14

公开(公告)号：US2825729A

公开(公告)日：1958-03-04

申请号：US51087055

申请日：1955-05-24

申请人： UPJOHN CO

发明人： PETERING HAROLD G ,  FALL HARRY H

IPC分类号： C07D475/14

CPC分类号： C07D475/14