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公开(公告)号：US20220409362A1
公开(公告)日：2022-12-29
申请号：US17898987
申请日：2022-08-30
Applicant: Gholam A. Peyman
Inventor： Gholam A. Peyman
Abstract: A method of lamellar corneal graft implantation is disclosed herein. In one or more embodiments, the method includes the steps of: (i) modifying a genetic component of a lamellar cornea or other tissue of an animal so that the lamellar cornea or other tissue of the animal can be used for human transplantation; (ii) decellularizing the lamellar cornea or other tissue ex vivo using chemical means; (iii) modifying a shape of the lamellar cornea or other tissue before or after transplantation; and (iv) applying a photosensitizer and ultraviolet radiation to the lamellar cornea or other tissue so as to crosslink collagen and intercellular proteins of the lamellar cornea or other tissue, kill the cells exposed to the photosensitizer, and eliminate an immune response by a host to the implanted lamellar cornea or the tissue.
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公开(公告)号：US11510776B2
公开(公告)日：2022-11-29
申请号：US16910925
申请日：2020-06-24
Applicant: Page Surgical Innovations, LLC
Inventor： Timothy Patrick Page
Abstract: A capsular tension ring inserter (10) and method includes a cannula (54) adapted to house a capsular tension ring (CTR) (26) having a leading eyelet (32), a hook element (56) disposed within the cannula (54) that engages and moves the CTR (26) during deployment, and a suture (28) placed on the leading eyelet (32) and fed back through the cannula (54) to allow a user to control insertion of tile CTR (26) into a capsular bag (42) of an eye (40) by pulling on the suture (28) during insertion of the CTR (26).
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43.发明授权
公开(公告)号：US11480798B2
公开(公告)日：2022-10-25
申请号：US17392957
申请日：2021-08-03
Applicant: Aperture in Motion, LLC
Inventor： Olivia Serdarevic , Edward Yavitz
IPC: G09G3/00 , G02B27/01 , A61F2/14 , A61F11/04 , A61B3/10 , G06T19/00 , A61F2/16 , A61B3/00 , A61N1/30
Abstract: Exemplary light control devices and methods provide a regional variation of visual information and sampling (“V-VIS”) of an ocular field of view that improves or stabilizes vision, ameliorates a visual symptom, reduces the rate of vision loss, or reduces the progression of an ophthalmic or neurologic condition, disease, injury or disorder. The V-VIS devices and methods generate a moving aperture effect anterior to a retina that samples and delivers to the retina environmental light from an ocular field of view at a sampling rate between 50 hertz and 50 kilohertz. Certain of these V-VIS devices and methods may be combined with augmented or virtual reality, vision measurement, vision monitoring, or other therapies including, but not limited to, pharmacological, gene, retinal replacement and stem cell therapies.
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公开(公告)号：US20220323204A1
公开(公告)日：2022-10-13
申请号：US17639219
申请日：2020-08-28
Applicant: Ocupeye Limited
Inventor： Stephen Geoffrey Bell , Gordon James Bott
IPC: A61F2/14 , B33Y50/00 , B29D11/02 , B29C64/386 , B33Y80/00
Abstract: A method (100) of forming an ocular prosthesis (13) comprising: receiving (102a) three dimensional scan data of a patients eye, the three dimensional scan data including volumetric data of at least an iris region, a pupil region and a cornea region of the eye; and forming (110) an ocular prosthesis (13) by an additive manufacturing process, the ocular prosthesis (13) having a body (15) with a volume, wherein the body of the prosthesis includes a three dimensional iris region (23), a three dimensional pupil region (25) and a three dimensional cornea region (26), and the volumetric data determines the size and shape of the iris region (23), the pupil region (25) and the cornea region (26) of the prosthesis (13).
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公开(公告)号：US11445723B2
公开(公告)日：2022-09-20
申请号：US16645145
申请日：2019-10-02
Applicant: The Doshisha
Inventor： Noriko Koizumi , Naoki Okumura
Abstract: The present disclosure provides a method of preserving corneal endothelial cells at a high cell survival rate. The present disclosure provides a method of preserving corneal endothelial cells and/or corneal endothelium-like cells, comprising preserving the corneal endothelial cells and corneal endothelium-like cells in a container with a bottom area of at least about 0.7 cm2. Accordingly to the present invention, corneal endothelial cells can be preserved at a high cell survival rate. Corneal endothelial cells preserved in this manner have functions of normal corneal endothelial cells. Such cells can also be used as cells for treating a corneal endothelial disease or the like.
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公开(公告)号：US20220287881A1
公开(公告)日：2022-09-15
申请号：US17656956
申请日：2022-03-29
Applicant: Michael S. BERLIN
Inventor： Michael S. BERLIN
IPC: A61F9/007 , A61B90/00 , A61F9/008 , A61B34/20 , G06N20/00 , A61B1/00 , A61F2/14 , A61M27/00 , G02B23/24
Abstract: An imaging probe comprises a camera or endoscope with an external detector array, in which the probe is sized and shaped for surgical placement in an eye to image the eye from an interior of the eye during treatment. The imaging probe and a treatment probe can be coupled together with a fastener or contained within a housing. The imaging probe and the treatment probe can be sized and shaped to enter the eye through an incision in the cornea and image one or more of the ciliary body band or the scleral spur. The treatment probe may comprise a treatment optical fiber or a surgical placement device to deliver an implant. A processor coupled to the detector can be configured with instructions to identify a location of one or more of the ciliary body band, the scleral spur, Schwalbe's line, or Schlemm's canal from the image.
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公开(公告)号：US20220241109A1
公开(公告)日：2022-08-04
申请号：US17625250
申请日：2020-07-08
Applicant: Robert I. Park
Inventor： Robert I. Park
Abstract: A rhegmatogenous retinal detachment (RRD) occurs when a tear in the retina leads to fluid accumulation with a separation of the neurosensory retina from the underlying retinal pigment epithelial (RPE); this is the most common type of retinal detachment and can lead to blindness. The present invention features an eye shape modification (ESM) system (a scleral buckle) for the prevention and repair of retinal detachment as well for the adjustment of refractive error and the prevention of induced refractive error caused by scleral buckles. The present invention creates a scleral buckle with protuberances on the interior surface of the buckle. These protuberances produce corrugation/indentations in the eye which allows for both axial and circumferential relaxation. Additionally, the present invention creates on scleral buckle that remove excess bulky material from the scleral buckle band, producing a scleral buckle that is easier and safer to surgically implant onto the eye.
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公开(公告)号：US20220233354A1
公开(公告)日：2022-07-28
申请号：US17457631
申请日：2021-12-03
Applicant: GLAUKOS CORPORATION
Inventor： David Steven Haffner , Henrick K. Gille , Charles Raymond Kalina, JR. , John Joseph Cogger
Abstract: Systems and methods for delivering multiple ocular implants to reduce intraocular pressure are disclosed. The ocular implants can be implanted at multiple sites within a single human eye without requiring removal of the delivery apparatus from the eye. A system for delivering multiple ocular implants can include at least two implants preloaded within a delivery device and configured to be implanted within the eye, a metering device configured to transfer energy to the implants for delivery at selected locations within the eye, wherein the metering device is configured to meter a variable amount of energy for each implant delivery event in the eye. The system can further include an injector mechanism configured to serially engage and drive each of the implants.
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公开(公告)号：US20220226156A1
公开(公告)日：2022-07-21
申请号：US17609754
申请日：2020-03-23
Applicant: Twenty Twenty Therapeutics LLC
Inventor： Shungneng Lee , Dimitri Azar
Abstract: An intraocular micro-display system includes an intraocular micro-display (IOMD) implant and an auxiliary head unit for delivering power and image data to the IOMD implant. The IOMD implant includes an enclosure shaped for implantation into an eye, a micro-display to emit images towards a retina, an energy storage unit to power the micro-display, a charging antenna for wireless charging of the energy storage unit via a power signal incident upon the first charging antenna, and a data antenna to wirelessly receive the image data for driving the micro-display to emit the images. The charging antenna and the data antenna are implantable into the eye with the IOMD implant.
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公开(公告)号：US20220212011A1
公开(公告)日：2022-07-07
申请号：US17704842
申请日：2022-03-25
Applicant: IRIDIUM MEDICAL TECHNOLOGY CO., LTD.
Inventor： Feng-Hsiung HSU , Yung-Chan CHEN , Long-Sheng FAN
Abstract: An artificial prosthesis is disclosed, which comprises a pixel array, a correlated double sampling unit, an analog-to-digital converter, a digital core, and a digital-to-analog converter. The digital core is configured to perform a calculation of electrical stimulation waveform of each of the pixels by using a processing function of an ANN. As such, the neural stimulation levels for artificial vision can be optimized.
