利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

67 条记录 (耗时 0.019 秒)

    Laser and acoustic lens for lithotripsy
    51.
    发明授权
    Laser and acoustic lens for lithotripsy 失效
    激光和声透镜用于碎石术

    公开(公告)号：US06491685B2

    公开(公告)日：2002-12-10

    申请号：US09516999

    申请日：2000-03-01

    申请人： Steven R. Visuri ,  Anthony J. Makarewicz ,  Richard A. London ,  William J. Benett ,  Peter Krulevitch ,  Luiz B. Da Silva

    发明人： Steven R. Visuri ,  Anthony J. Makarewicz ,  Richard A. London ,  William J. Benett ,  Peter Krulevitch ,  Luiz B. Da Silva

    IPC分类号： A61B1722

    CPC分类号： A61B18/26 ,  A61B2018/263

    摘要： An acoustic focusing device whose acoustic waves are generated by laser radiation through an optical fiber. The acoustic energy is capable of efficient destruction of renal and biliary calculi and deliverable to the site of the calculi via an endoscopic procedure. The device includes a transducer tip attached to the distal end of an optical fiber through which laser energy is directed. The transducer tip encapsulates an exogenous absorbing dye. Under proper irradiation conditions (high absorbed energy density, short pulse duration) a stress wave is produced via thermoelastic expansion of the absorber for the destruction of the calculi. The transducer tip can be configured into an acoustic lens such that the transmitted acoustic wave is shaped or focused. Also, compressive stress waves can be reflected off a high density/low density interface to invert the compressive wave into a tensile stress wave, and tensile stresses may be more effective in some instances in disrupting material as most materials are weaker in tension than compression. Estimations indicate that stress amplitudes provided by this device can be magnified more than 100 times, greatly improving the efficiency of optical energy for targeted material destruction.

    摘要翻译： 声波聚焦装置，其声波通过激光辐射通过光纤产生。 声能能够有效地破坏肾脏和胆汁结石，并可通过内窥镜手术递送至结石部位。 该装置包括附接到光纤的远端的换能器尖端，通过激光能量被引导。 换能器尖端封装外源吸收染料。 在适当的照射条件（高吸收能量密度，短脉冲持续时间）下，通过吸收器的热弹性膨胀产生应力波，以破坏结石。 换能器尖端可以被配置成声透镜，使得发射的声波成形或聚焦。 此外，压应力波可以从高密度/低密度界面反射，以将压缩波反转成拉伸应力波，并且拉伸应力在某些情况下在破坏材料中可能更有效，因为大多数材料的张力比压缩弱。 估计表明，该装置提供的应力幅度可以放大100倍以上，大大提高了光能量对目标材料的破坏效率。

    FLEXIBLE INDWELLING BIOSENSOR, FLEXIBLE INDWELLING BIOSENSOR INSERTION DEVICE, AND RELATED METHODS
    57.
    发明申请
    FLEXIBLE INDWELLING BIOSENSOR, FLEXIBLE INDWELLING BIOSENSOR INSERTION DEVICE, AND RELATED METHODS 审中-公开
    柔性生物传感器，柔性生物传感器插入装置及相关方法

    公开(公告)号：US20100198033A1

    公开(公告)日：2010-08-05

    申请号：US12366466

    申请日：2009-02-05

    申请人： Peter KRULEVITCH ,  Donna SAVAGE ,  Lorin P. OLSON ,  Leif BOWMAN

    发明人： Peter KRULEVITCH ,  Donna SAVAGE ,  Lorin P. OLSON ,  Leif BOWMAN

    IPC分类号： A61B5/145

    CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61B5/6848 ,  A61B5/6849

    摘要： A flexible indwelling biosensor includes an elongated framework formed from a flexible material (e.g., a Nitinol strip) with a body portion, a sharp head, a distal end, and a proximal end. The flexible indwelling sensor also includes a biosensor (such as an interstitial fluid glucose sensor) integrated with the elongated framework with the biosensor having a sensing element disposed over (for example, on or suspended over) at least one of the body portion or sharp head of the elongated framework. Moreover, the sharp head is disposed at the distal end of the elongated framework and the sharp head and at least the sensing element of the biosensor are configured for insertion into a target site (for example, a subcutaneous target site).

    摘要翻译： 柔性留置生物传感器包括由具有主体部分，尖头，远端和近端的柔性材料（例如，镍钛诺带）形成的细长骨架。 柔性留置传感器还包括与细长框架集成的生物传感器（例如间质流体葡萄糖传感器），其中生物传感器具有设置在（例如，在其上或悬挂在其上）主体部分或尖头中的至少一个的感测元件 的细长框架。 此外，尖头设置在细长框架的远端并且尖锐头部，并且至少生物传感器的感测元件构造成用于插入目标部位（例如，皮下靶位点）。

    Polymer-based platform for microfluidic systems
    59.
    发明授权
    Polymer-based platform for microfluidic systems 有权

    公开(公告)号：US07601286B2

    公开(公告)日：2009-10-13

    申请号：US10107933

    申请日：2002-03-26

    申请人： William Benett ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  Klint Rose ,  Amy W. Wang

    发明人： William Benett ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  Klint Rose ,  Amy W. Wang

    IPC分类号： B29C33/76

    CPC分类号： B29C39/10 ,  B29C33/3842 ,  B29C39/34 ,  B29K2083/00 ,  B29K2083/005 ,  B29L2031/24 ,  B29L2031/756

    摘要： A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure. Microdevices may be embedded within the cast polymer-based platform, or bonded to the platform structure subsequent to molding, to create an integrated microfluidic system. In this manner, the new microfluidic platform is versatile and capable of quickly generating prototype systems, and could easily be adapted to a manufacturing setting.

    Medical Device Mechanical Pump
    60.
    发明申请
    Medical Device Mechanical Pump 审中-公开
    医疗器械机械泵

    公开(公告)号：US20090247982A1

    公开(公告)日：2009-10-01

    申请号：US12407173

    申请日：2009-03-19

    申请人： Peter Krulevitch ,  Robert Wilk ,  Sean O'Connor ,  Mingqi Zhao ,  Zara Sieh ,  Donna Savage

    发明人： Peter Krulevitch ,  Robert Wilk ,  Sean O'Connor ,  Mingqi Zhao ,  Zara Sieh ,  Donna Savage

    IPC分类号： A61M1/00 ,  H04Q5/22

    CPC分类号： A61M5/14248 ,  A61M5/14224 ,  A61M5/1424 ,  A61M5/38 ,  A61M2005/1405 ,  A61M2005/14252 ,  A61M2205/0294 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/825

    摘要： A medical device pump with a housing with a compartment for removably receiving a cartridge containing a therapeutic agent, a conduit configured to operatively provide a fluid flow path for therapeutic agent to exit from the cartridge, a user activated delivery button, a trigger mechanism, and a mechanical pump mechanism. The trigger mechanism, user activated delivery button and mechanical pump mechanism of the medical device pump are configured such that the trigger mechanism is activated by a user fully activating the user activated delivery button. Moreover, such full activation generates mechanical power employed by, and sufficient for, the mechanical pump mechanism to pump a predetermined volume of therapeutic agent from the cartridge and through the fluid flow path.

    摘要翻译： 一种具有壳体的医疗装置泵，具有用于可拆卸地容纳包含治疗剂的药筒的隔室，构造成可操作地提供用于治疗剂从药筒离开的流体流动路径的管道，用户激活的递送按钮，触发机构和 机械泵机构。 触发机构，用户激活的输送按钮和医疗装置泵的机械泵机构被配置为使得触发机构被用户激活，完全激活用户激活的递送按钮。 此外，这种完全激活产生机械功率，并且足以使机械泵机构从盒中泵送预定量的治疗剂并通过流体流动路径。