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51.发明公开公开(公告)号：US20230293662A1
公开(公告)日：2023-09-21
申请号：US18069058
申请日：2022-12-20
Inventor： Theodore Randolph , Robert Garcea , Kimberly J. Hassett
IPC: A61K39/12 , A61K39/295 , A61K45/06
CPC classification number: A61K39/12 , A61K39/295 , A61K45/06 , A61K2039/5252
Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.
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公开(公告)号：US20230281728A1
公开(公告)日：2023-09-07
申请号：US18000314
申请日：2021-06-01
Inventor： Lise A. St. Denis
IPC: G06Q50/00 , G06Q50/26 , G06F18/2415
CPC classification number: G06Q50/01 , G06F18/2415 , G06Q50/265
Abstract: Various embodiments of the present disclosure relate to a multimodal data classifier, and a method of training the classifier therein, that identifies social network messages about an event and filters the messages to provide a reduced amount of content to assist emergency authorities. For each message identified, the classification model identifies features of the message including an account identity and content of the message. Further, it generates a feature embedding for the message based at least on the account identity and the content of the message, and it submits the feature embeddings as input to a machine learning model to obtain one or more classifications for the message. As a result, the data classifier filters the messages based on the one or more classifications, which provides a prioritized view of the messages based on training criteria.
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公开(公告)号：US20230273474A1
公开(公告)日：2023-08-31
申请号：US18114782
申请日：2023-02-27
Inventor： Souvik Ghosh , Ivan Smalyukh
IPC: G02F1/1334 , G08C23/04 , C09K19/56
CPC classification number: G02F1/1334 , G08C23/04 , C09K19/56 , B82Y30/00
Abstract: Assemblies and methods for modulating (e.g., near) infrared radiation are provided. Exemplary assemblies include a composite material interposed between a first substrate and a second substrate. The composite material includes plasmonic nanoparticles (e.g., nanoplates) dispersed in a nematic liquid crystal.
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54.发明公开
公开(公告)号：US20230257741A1
公开(公告)日：2023-08-17
申请号：US17759402
申请日：2021-01-29
Inventor： Gabrijela Dumbovic , John Rinn , Marvin Caruthers , Katarzyna Jastrzebska , Heera K. Langner
IPC: C12N15/113 , A61K31/7115 , A61P35/00
CPC classification number: C12N15/113 , A61K31/7115 , A61P35/00
Abstract: The inventive technology relates to systems and methods for the use of chemically modified antisense oligonucleotides (ASOs) to sterically prevent intron excision thus causing nuclear retention of the RNA and inhibiting nuclear export. In preferred therapeutic embodiments, ASOs may be engineered to quarantine clinically relevant RNAs in the nucleus of the cell.
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公开(公告)号：US20230250025A1
公开(公告)日：2023-08-10
申请号：US18127498
申请日：2023-03-28
Inventor： Christopher Bartel , Alan W. Weimer , Rebecca Jean O'Toole , Maila Kodas
IPC: C04B35/488 , C04B35/624 , C04B35/628 , H01M8/1253
CPC classification number: C04B35/4885 , C04B35/624 , C04B35/62813 , H01M8/1253 , C04B2235/3217 , C04B2235/3246 , C04B2235/6026 , H01M2008/1293
Abstract: Disclosed herein is a ceramic particle comprising a core substrate chosen from yttria-stabilized zirconia, partially stabilized zirconia, zirconium oxide, aluminum nitride, silicon nitride, silicon carbide, and cerium oxide, and a conformal coating of a sintering aid film having a thickness of less than three nanometers and covering the core substrate, and methods for producing the ceramic particle.
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公开(公告)号：US11717140B2
公开(公告)日：2023-08-08
申请号：US16573567
申请日：2019-09-17
Inventor： Joel Friedlander , Jeremy Prager , Emily Deboer , Robin Deterding
IPC: A61B1/00 , A61B1/233 , A61M21/00 , A61B5/0205 , A61B90/00 , A61B5/06 , A61B5/01 , A61B3/16 , A61B3/11 , A61B5/12 , A61B5/03 , A61B7/00 , A61B5/00 , A61B5/1455 , A61B5/145 , G06F3/14 , A61B5/08 , A61B5/021 , A61B5/024
CPC classification number: A61B1/00097 , A61B1/233 , A61B3/111 , A61B3/112 , A61B3/16 , A61B5/01 , A61B5/02055 , A61B5/03 , A61B5/062 , A61B5/064 , A61B5/126 , A61B5/14517 , A61B5/14552 , A61B5/442 , A61B5/6803 , A61B7/003 , A61B90/39 , G06F3/14 , A61B5/021 , A61B5/024 , A61B5/082 , A61B5/0816 , A61B2090/3945 , A61B2090/3954 , A61M2021/005 , A61M2021/0027
Abstract: A system having a scope with a longitudinal length extending between a proximal end and a distal end includes a plurality of markers spaced along the longitudinal length. The system also includes a disassociation and positioning device that is configured to enhance unsedated transnasal endoscopic procedures by at least partially occluding the vision of a patient while enabling body cavity access, and optionally record and sense body functions such as temperature, heart rate and oxygenation of the blood stream. The system further includes a sensor integrated into the distraction device, wherein the sensor is configured to detect the markers on the longitudinal length of the scope.
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57.发明公开
公开(公告)号：US20230233517A1
公开(公告)日：2023-07-27
申请号：US17852475
申请日：2022-06-29
Inventor： Ding Xue , Yu Peng , Man Zhang , Lingjun Zheng , Qian Liang , Hanzeng Li , Jau-Song Yu , Jeng-Ting Chen
IPC: A61K31/353 , A61K31/336 , A61K31/4025 , A61K31/7048
CPC classification number: A61K31/353 , A61K31/336 , A61K31/4025 , A61K31/7048
Abstract: The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.
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公开(公告)号：US11709132B2
公开(公告)日：2023-07-25
申请号：US16302911
申请日：2017-05-18
Inventor： Michael Tanksalvala , Daniel E. Adams , Dennis Gardner , Christina L. Porter , Giulia F. Mancini , Margaret M. Murnane , Henry C. Kapteyn
IPC: G01N21/47 , G01N21/956 , G01N21/45 , G01N21/33 , G01N21/17
CPC classification number: G01N21/4788 , G01N21/33 , G01N21/45 , G01N21/4795 , G01N21/956 , G01N2021/1782 , G01N2021/335 , G01N2021/4711 , G01N2201/061
Abstract: Apparatus and methods for forming an image of an object which involves focusing partially to fully spatially-coherent radiation onto a sample and collecting the resulting scattered radiation (the “standard data set”) on an array detector. In addition to the standard dataset, an additional measurement or plurality of measurements is made of a relatively-unscattered beam, using the array detector, which comprises the “modulus enforced probe (MEP) dataset”. This MEP dataset serves as an extra constraint, called the MEP constraint, in the phase retrieval algorithm used to reconstruct the image of the object.
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公开(公告)号：US20230174614A1
公开(公告)日：2023-06-08
申请号：US17997575
申请日：2021-04-30
Inventor： Terry J. FRY
IPC: C07K14/705 , A61P35/02 , C12N15/63 , A61K35/17
CPC classification number: C07K14/70503 , A61P35/02 , C12N15/63 , A61K35/17
Abstract: The present disclosure provides multispecific chimeric antigen receptors (CARs) having antigenic specificity for FLT3 and CD19, FLT3 and CD22, FLT3 and CD123 or FLT3 and CD33. Nucleic acids, expression constructs, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the multispecific CARs are disclosed. Methods of treating or preventing ALL, AML and/or other forms of cancer in a mammal are also disclosed.
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公开(公告)号：US20230132035A1
公开(公告)日：2023-04-27
申请号：US17962656
申请日：2022-10-10
Inventor： Hang Hubert Yin , Shuting Zhang , Zhenyi Hu
IPC: C07D401/04 , C07D215/20 , A61P19/02 , A61P37/06
Abstract: Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
