公开(公告)号：US08579962B2

公开(公告)日：2013-11-12

申请号：US11314969

申请日：2005-12-20

申请人： Amr Salahieh ,  Dwight P. Morejohn ,  Daniel Hildebrand ,  Tom Saul

发明人： Amr Salahieh ,  Dwight P. Morejohn ,  Daniel Hildebrand ,  Tom Saul

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61B2017/00783 ,  A61F2/2412 ,  A61F2/2439 ,  A61F2002/9517 ,  A61F2250/0097

摘要： The present invention relates to apparatus and methods for performing valvuloplasty. In some embodiments, the apparatus includes an expandable braid valvuloplasty device. In some embodiments, the methods and apparatus may be used as an adjunct to percutaneous heart valve replacement. In some embodiments, the apparatus and methods may provide a medical practitioner with feedback, monitoring or measurement information, e.g., information relevant to percutaneous transcatheter heart valve replacement.

摘要翻译： 本发明涉及进行瓣膜成形术的装置和方法。 在一些实施例中，该装置包括可扩张的编织瓣膜成形术装置。 在一些实施例中，方法和装置可以用作经皮心脏瓣膜置换的辅助装置。 在一些实施例中，该装置和方法可以向医务人员提供反馈，监测或测量信息，例如与经皮经导管心脏瓣膜置换相关的信息。

公开(公告)号：US20130013057A1

公开(公告)日：2013-01-10

申请号：US13612119

申请日：2012-09-12

申请人： Amr Salahieh ,  Ulrich R. Haug ,  Claudio Argento ,  Dwight Morejohn ,  Daniel Hildebrand ,  Tom Saul

发明人： Amr Salahieh ,  Ulrich R. Haug ,  Claudio Argento ,  Dwight Morejohn ,  Daniel Hildebrand ,  Tom Saul

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2439 ,  A61F2002/9517 ,  A61F2230/0054 ,  A61M25/0136 ,  A61M25/0144 ,  A61M25/0147

摘要： A medical implant deployment tool and deployment method are disclosed. One aspect of the invention provides an implant system including an implant adapted for endovascular delivery and deployment; and a deployment tool adapted to deploy the implant, with the deployment tool having an actuation controller; a plurality of actuation elements adapted to apply forces to one or more implant deployment mechanisms and each adapted to extend along an actuation element path within a patient's vasculature; and an actuation element compensation mechanism adapted to compensate for differences in length between the actuation element paths.

摘要翻译： 公开了一种医用植入物部署工具和部署方法。 本发明的一个方面提供一种植入系统，其包括适于血管内递送和展开的植入物; 以及适于部署所述植入物的部署工具，所述展开工具具有致动控制器; 多个致动元件，其适于向一个或多个植入物展开机构施加力并且每个适于沿着病人脉管系统内的致动元件路径延伸; 以及致动元件补偿机构，其适于补偿致动元件路径之间的长度差异。

公开(公告)号：US20120132547A1

公开(公告)日：2012-05-31

申请号：US13367733

申请日：2012-02-07

申请人： Amr Salahieh ,  Tom Saul ,  Robert Geshlider ,  Andrea Johnson ,  Dwight Morejohn ,  Daniel Hildebrand ,  Jean-Pierre Dueri

发明人： Amr Salahieh ,  Tom Saul ,  Robert Geshlider ,  Andrea Johnson ,  Dwight Morejohn ,  Daniel Hildebrand ,  Jean-Pierre Dueri

IPC分类号： A61J1/00 ,  B65D81/32

CPC分类号： B65D25/04 ,  A61F2/0095 ,  A61F2/2427 ,  A61F2002/9517 ,  B65B5/04 ,  B65B55/16 ,  B65D41/04 ,  B65D81/22

摘要： The invention provides a two-part package and method of use for a pre-attached medical implant and delivery tool system. The package includes a wet compartment and a dry compartment and allows a pre-attached implant and delivery tool system to be at least partially stored immersed in a fluid in the wet compartment and at least partially stored in the dry compartment. In one embodiment the implant comprises a replacement heart valve, and the heart valve is stored inside the wet compartment while the heart valve delivery tool remains dry in the dry compartment.

摘要翻译： 本发明提供了用于预附接的医疗植入物和递送工具系统的两部分包装和使用方法。 该包装包括湿室和干燥室，并且允许将预先附着的植入物和递送工具系统至少部分地储存在浸入湿室中的流体中并且至少部分储存在干燥室中。 在一个实施例中，植入物包括置换心脏瓣膜，并且心脏瓣膜储存在湿室内，而心脏瓣膜递送工具在干燥室中保持干燥。

公开(公告)号：US07824443B2

公开(公告)日：2010-11-02

申请号：US11275912

申请日：2006-02-02

申请人： Amr Salahieh ,  Dwight Morejohn ,  Ulrich R. Haug ,  Brian Brandt ,  Hans Valencia ,  Tom Saul

发明人： Amr Salahieh ,  Dwight Morejohn ,  Ulrich R. Haug ,  Brian Brandt ,  Hans Valencia ,  Tom Saul

IPC分类号： A61F2/24

CPC分类号： A61F2/2439 ,  A61B17/068 ,  A61B2017/00243 ,  A61F2/2418 ,  A61F2/90 ,  A61F2002/9517

摘要： An apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes a replacement heart valve implant comprising a valve and an expandable anchor; and a deployment tool adapted to endovascularly deliver the replacement heart valve implant to an implant site within the patient, the deployment tool comprising an actuator adapted to exert an axially directed force on the anchor. The invention also provides a method for endovascularly replacing a heart valve of a patient. In some embodiments, the method includes the steps of endovascularly delivering a replacement heart valve implant having a valve and an anchor to an implant site within the patient; and applying an axially directed force from an actuator outside of the patient to the anchor. In invention also provides deployment tools for performing the method.

摘要翻译： 用于血管内置换患者心脏瓣膜的装置。 在一些实施例中，该装置包括置换心脏瓣膜植入体，其包括阀和可扩张锚; 以及适于将替代心脏瓣膜植入物血管内输送到患者体内的植入部位的部署工具，所述展开工具包括适于在锚固件上施加轴向力的致动器。 本发明还提供一种用于血管内替换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：血管内递送具有瓣膜和锚的置换心脏瓣膜植入物到患者体内的植入部位; 以及将来自所述患者外部的致动器的轴向力施加到所述锚固件。 本发明还提供了用于执行该方法的部署工具。

公开(公告)号：US07780725B2

公开(公告)日：2010-08-24

申请号：US10870340

申请日：2004-06-16

申请人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

发明人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

IPC分类号： A61F2/06

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078

摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

摘要翻译： 本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。 该装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。 在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。 在一些实施例中，替换阀不连接到锚的可膨胀部分。 在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。 在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。 在一些实施例中，锚固件包括由单股线制成的编织物。 在一些实施例中，该装置包括被配置成保持锚固扩展的锁。 本发明还包括用于血管内替代患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。

公开(公告)号：US20090076598A1

公开(公告)日：2009-03-19

申请号：US12269213

申请日：2008-11-12

申请人： Amr Salahieh ,  Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

发明人： Amr Salahieh ,  Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078

摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

公开(公告)号：US07445631B2

公开(公告)日：2008-11-04

申请号：US10893142

申请日：2004-07-15

申请人： Amr Salahieh ,  Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Dwight P. Morejohn

发明人： Amr Salahieh ,  Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Dwight P. Morejohn

IPC分类号： A61F2/24

CPC分类号： A61F2/2409 ,  A61F2/013 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/0036 ,  A61F2250/0039

摘要： The present invention relates to an apparatus for replacing a native aortic valve, the apparatus includes an expandable anchor adapted to be endovascularly delivered and secured at a site within the native aortic valve. The expandable anchor has a delivery length in a delivery configuration substantially greater than a deployed length in a deployed configuration. The apparatus may also include and a replacement valve configured to be secured within the anchor.

摘要翻译： 本发明涉及一种用于替换天然主动脉瓣的装置，该装置包括适于在血管内递送和固定在天然主动脉瓣内的部位的可扩张锚。 可扩展锚具在传送配置中的传送长度实质上大于部署配置中展开的长度。 该装置还可以包括配置成固定在锚中的替换阀。

公开(公告)号：US20060173524A1

公开(公告)日：2006-08-03

申请号：US11275912

申请日：2006-02-02

申请人： Amr Salahieh ,  Dwight Morejohn ,  Ulrich Haug ,  Brian Brandt ,  Hans Valencia ,  Tom Saul

发明人： Amr Salahieh ,  Dwight Morejohn ,  Ulrich Haug ,  Brian Brandt ,  Hans Valencia ,  Tom Saul

IPC分类号： A61F2/06

CPC分类号： A61F2/2439 ,  A61B17/068 ,  A61B2017/00243 ,  A61F2/2418 ,  A61F2/90 ,  A61F2002/9517

摘要： An apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes a replacement heart valve implant comprising a valve and an expandable anchor; and a deployment tool adapted to endovascularly deliver the replacement heart valve implant to an implant site within the patient, the deployment tool comprising an actuator adapted to exert an axially directed force on the anchor. The invention also provides a method for endovascularly replacing a heart valve of a patient. In some embodiments, the method includes the steps of endovascularly delivering a replacement heart valve implant having a valve and an anchor to an implant site within the patient; and applying an axially directed force from an actuator outside of the patient to the anchor. In invention also provides deployment tools for performing the method.

摘要翻译： 用于血管内置换患者心脏瓣膜的装置。 在一些实施例中，该装置包括置换心脏瓣膜植入体，其包括阀和可扩张锚; 以及适于将替代心脏瓣膜植入物血管内输送到患者体内的植入部位的部署工具，所述展开工具包括适于在锚固件上施加轴向力的致动器。 本发明还提供一种用于血管内替换患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：血管内递送具有瓣膜和锚的置换心脏瓣膜植入物到患者体内的植入部位; 以及将来自所述患者外部的致动器的轴向力施加到所述锚固件。 本发明还提供了用于执行该方法的部署工具。

公开(公告)号：US20050137697A1

公开(公告)日：2005-06-23

申请号：US10971535

申请日：2004-10-21

申请人： Amr Salahieh ,  Brian Brandt ,  Robert Geshlider ,  Dwight Morejohn ,  Tom Saul

发明人： Amr Salahieh ,  Brian Brandt ,  Robert Geshlider ,  Dwight Morejohn ,  Tom Saul

IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/90

CPC分类号： A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2002/9528 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/006

摘要： The present invention relates to apparatus for methods for endovascularly replacing a patient's heart valve. The apparatus includes an expandable anchor with leaflet engagement elements on the proximal end of the anchor and a replacement valve. The leaflet engagement elements can be used to prevent distal migration and insure proper positioning of the apparatus.

公开(公告)号：US08992608B2

公开(公告)日：2015-03-31

申请号：US12492512

申请日：2009-06-26

申请人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

发明人： Ulrich R. Haug ,  Hans F. Valencia ,  Robert A. Geshlider ,  Tom Saul ,  Amr Salahieh ,  Dwight P. Morejohn ,  Kenneth J. Michlitsch

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0065 ,  A61F2230/0078

摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

摘要翻译： 本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。 该装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。 在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。 在一些实施例中，替换阀不连接到锚的可膨胀部分。 在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。 在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。 在一些实施例中，锚固件包括由单股线制成的编织物。 在一些实施例中，该装置包括被配置成保持锚固扩展的锁。 本发明还包括用于血管内替代患者心脏瓣膜的方法。 在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。