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156 条记录 (耗时 0.045 秒)

    Hydrolysis of acylamino acids
    55.
    发明授权
    Hydrolysis of acylamino acids 有权
    酰氨基酸的水解

    公开(公告)号：US06552222B2

    公开(公告)日：2003-04-22

    申请号：US09927776

    申请日：2001-08-13

    申请人： Klaus Huthmacher ,  Christoph Weckbecker ,  Horst Weigel

    发明人： Klaus Huthmacher ,  Christoph Weckbecker ,  Horst Weigel

    IPC分类号： C07C32300

    CPC分类号： C07C227/20 ,  C07C319/20 ,  C07C229/08 ,  C07C323/58

    摘要： A process for the preparation of racemic amino acids, characterized in that an acylamino acid of the formula R1—CH(NH—CO—R2)COOH wherein R1 is hydrogen, a linear, branched or cyclic alkyl that has from 1 to 7 carbon atoms and that may contain substituents such as a hydroxyl, alkyloxy or alkylthio group; and R2 is a hydrogen atom or an alkyl having from 1 to 3 carbon atoms; is heated in the presence of water, in a pressure-resistant vessel, to a temperature in the range from 110° C. to 220° C. and is hydrolyzed.

    摘要翻译： 一种制备外消旋氨基酸的方法，其特征在于式R 1的酰基氨基酸是氢，具有1至7个碳原子并且可以含有取代基的直链，支链或环状烷基，例如羟基，烷氧基或 烷硫基 并且R 2是氢原子或具有1至3个碳原子的烷基; 在水的存在下，在耐压容器中加热至110℃至220℃的温度，并水解。

    Process for the production of 2,3,5-trimethylhydroquinone diesters
    58.
    发明授权
    Process for the production of 2,3,5-trimethylhydroquinone diesters 失效
    制备2,3,5-三甲基氢醌二酯的方法

    公开(公告)号：US06417409B1

    公开(公告)日：2002-07-09

    申请号：US09502229

    申请日：2000-02-11

    申请人： Steffen Krill ,  Klaus Huthmacher

    发明人： Steffen Krill ,  Klaus Huthmacher

    IPC分类号： C07C3700

    CPC分类号： C07C67/00 ,  Y02P20/582 ,  C07C69/017 ,  C07C69/16

    摘要： The invention relates to an improved process for the production of 2,3,5-trimethylhydroquinone diesters by rearrangement of 2,6,6-trimethyl-2-cyclohexene-1,4-dione (4-oxoisophorone, ketoisophorone) in the presence of a dissolved, acidic catalyst and an acylating agent, such as for example carboxylic anhydrides or carboxylic acid halides. The 2,3,5-trimethylhydroquinone diester can optionally then be saponified to give free 2,3,5-trimethylhydroquinone (TMHQ), which is a valuable building block in the synthesis of vitamin E.

    摘要翻译： 本发明涉及通过在2,6,6-三甲基-2-环己烯-1,4-二酮（4-氧代异佛尔酮，酮异佛尔酮）的存在下重排来制备2,3,5-三甲基氢醌二酯的改进方法 溶解的酸性催化剂和酰化剂，例如羧酸酐或羧酸卤化物。 可以任选地将2,3,5-三甲基氢醌二酯皂化，得到游离的2,3,5-三甲基氢醌（TMHQ），其是维生素E合成中的有价值的结构单元。

    Process for the production of 2,3,5-trimethylhydroquinone diesters
    60.
    发明授权
    Process for the production of 2,3,5-trimethylhydroquinone diesters 失效
    制备2,3,5-三甲基氢醌二酯的方法

    公开(公告)号：US06316661B1

    公开(公告)日：2001-11-13

    申请号：US09493065

    申请日：2000-01-28

    申请人： Steffen Krill ,  Horst Weigel ,  Klaus Huthmacher ,  Nongyuan Shi ,  Georg Markowz ,  Volker Hafner

    发明人： Steffen Krill ,  Horst Weigel ,  Klaus Huthmacher ,  Nongyuan Shi ,  Georg Markowz ,  Volker Hafner

    IPC分类号： C07C6900

    CPC分类号： C07C67/00 ,  Y02P20/582 ,  C07C69/017 ,  C07C69/16 ,  C07C69/28

    摘要： A process for the production of 2,3,5-trimethylhydroquinone diesters by aromatization of 2,6,6-trimethyl-2-cyclohexene-1,4-dione (4-oxoisophorone, ketoisophorone, KIP) with an acylating agent and an acidic soluble or insoluble catalyst, which process may be operated alternatively continuously or discontinuously. The process includes the following steps: a) a carboxylic anhydride having a C1 to C4 alkyl residue is used as the acylating agent, b) after the reaction, a proportion of the resultant carboxylic acid is optionally removed by distillation, c) the reaction solution is cooled, d) the product which has crystallized out is separated and washed, and e) the filtrate is returned to step a).

    摘要翻译： 通过2,6,6-三甲基-2-环己烯-1,4-二酮（4-氧异佛尔酮，酮异佛尔酮，KIP）与酰化剂和酸性化合物的芳构化生产2,3,5-三甲基氢醌二酯的方法 可溶或不溶的催化剂，该方法可以交替连续或不连续地操作。 该方法包括以下步骤：a）具有C1至C4烷基残基的羧酸酐用作酰化剂，b）反应后，任选地通过蒸馏除去所得羧酸的一部分，c）反应溶液 被冷却，d）结晶出来的产物被分离和洗涤，e）将滤液返回到步骤a）。