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    Hemispherands and sodium-selective compositions and electrodes containing same
    54.
    发明授权
    Hemispherands and sodium-selective compositions and electrodes containing same 失效
    半球和钠选择性组合物和含有它们的电极

    公开(公告)号：US4476007A

    公开(公告)日：1984-10-09

    申请号：US496740

    申请日：1983-05-20

    申请人： John L. Toner ,  Daniel S. Daniel ,  Susan M. Geer

    发明人： John L. Toner ,  Daniel S. Daniel ,  Susan M. Geer

    IPC分类号： C07D273/01 ,  C07D498/22 ,  G01N27/333 ,  G01N27/30

    CPC分类号： C07D498/22 ,  G01N27/3335

    摘要： Ion-selective compositions which comprise an ion carrier, a compound capable of solvating the ion carrier, and a supporting matrix are disclosed.The ion carriers of this invention are hemispherand compounds represented by the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently hydrogen, alkyl, alkenyl, cycloalkyl, aryl or a heterocyclic group; and X is benzyl or an electron donating group capable of forming at least one coordinating site for sodium ions. A preferred hemispherand according to this invention is 2'-benzyloxy-3,3"-[2,6-pyridylenebis(methyleneoxymethylene)]-2,2"-tetramethylenedioxy-5,5',5"-trimethyl-1,1':3',1"-terphenyl. These compounds and the compositions containing same are particularly useful in ion-selective electrodes. Such an electrode is capable of selectively transporting sodium ions in preference to other cations. Dry-operative electrodes using these ion-selective compositions as membranes are also disclosed.

    摘要翻译： 公开了包含离子载体，能够溶剂化离子载体的化合物和支持基质的离子选择性组合物。 本发明的离子载体是由下式表示的半胱氨酸化合物，其中R 1，R 2，R 3和R 4独立地为氢，烷基，烯基，环烷基，芳基或杂环基; X是苄基或能形成钠离子的至少一个配位部位的给电子基团。 根据本发明的优选的半球是2'-苄氧基-3,3“ - [2,6-亚吡啶基二（亚甲氧基亚甲基）] - 2,2” - 叔亚甲基二氧基-5,5'，5“ - 三甲基 - 1,1'：3'，1“ - 三联苯。 这些化合物和含有它们的组合物在离子选择性电极中特别有用。 这种电极能够选择性地输送钠离子优于其它阳离子。 还公开了使用这些离子选择性组合物作为膜的干手术电极。

    Compositions and methods of administering paclitaxel with other drugs using medical devices
    57.
    发明授权
    Compositions and methods of administering paclitaxel with other drugs using medical devices 有权
    使用医疗器械给予紫杉醇与其他药物的组合物和方法

    公开(公告)号：US08057816B2

    公开(公告)日：2011-11-15

    申请号：US11548974

    申请日：2006-10-12

    申请人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack

    发明人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack

    IPC分类号： A61F2/00 ,  A01N63/00 ,  A01N43/42 ,  A01N43/04 ,  A61K39/395 ,  A61K31/44 ,  A61K31/56 ,  A61K31/727 ,  A61K31/355

    CPC分类号： A61K31/337 ,  A61K9/0024 ,  A61K31/436 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  C07D498/18

    摘要： Systems and compositions comprising paclitaxel and a second drug, such as rapamycin, analogs, derivatives, salts and esters thereof are disclosed, as well as methods of delivery wherein the drugs have effects that complement each other. Medical devices comprising supporting structures capable of including or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient can contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating including the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

    摘要翻译： 公开了包含紫杉醇和第二药物如雷帕霉素，类似物，衍生物，盐和酯的系统和组合物，以及其中药物具有互补作用的递送方法。 包含能够包含或支持药学上可接受的载体或赋形剂的支持结构的医疗装置，所述载体或赋形剂可以含有一种或多种治疗剂或物质，所述载体优选在其表面上包括涂层，所述包衣包含治疗物质 ，例如药物。 适用于本发明的医疗装置的支撑结构包括冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。

    Multiple Drug Delivery From A Balloon And A Prosthesis
    58.
    发明申请
    Multiple Drug Delivery From A Balloon And A Prosthesis 有权
    从气球和假体的多个药物递送

    公开(公告)号：US20100023108A1

    公开(公告)日：2010-01-28

    申请号：US12371422

    申请日：2009-02-13

    申请人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Randolf von Oepen

    发明人： John L. Toner ,  Sandra E. Burke ,  Keith R. Cromack ,  Randolf von Oepen

    IPC分类号： A61F2/84 ,  A61F2/82

    CPC分类号： A61L31/16 ,  A61F2/91 ,  A61F2/958 ,  A61F2230/0054 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606 ,  A61M25/10 ,  A61M2025/105

    摘要： Disclosed is an interventional device for delivery of therapeutic agents from an angioplasty balloon and from a prosthesis such as an intraluminal stent. The invention also relates to the method of loading the beneficial agents onto the balloon and the device, as well as the method of delivery of the agents from separate surfaces. The invention also relates to an interventional device having a prosthesis surface that is loaded with a first beneficial agent, and a balloon surface loaded with a second beneficial agent. The invention also relates to a method of loading multiple beneficial agents onto the prosthesis surfaces and the balloon surfaces, and to a method of manufacturing an interventional device for the delivery of a first beneficial agent and a second beneficial agent from separate surfaces.

    摘要翻译： 公开了用于从血管成形术球囊和诸如腔内支架之类的假体递送治疗剂的介入装置。 本发明还涉及将有益试剂装载到球囊和装置上的方法以及将试剂从分开的表面递送的方法。 本发明还涉及具有装载有第一有益试剂的假体表面的介入装置和装载有第二有益试剂的气囊表面。 本发明还涉及一种将多种有益试剂装载到假体表面和球囊表面上的方法，以及制造用于从单独表面递送第一有益试剂和第二有益试剂的介入装置的方法。

    Medical Devices Containing Rapamycin Analogs
    59.
    发明申请
    Medical Devices Containing Rapamycin Analogs 审中-公开
    含雷帕霉素类似物的医疗器械

    公开(公告)号：US20090047323A1

    公开(公告)日：2009-02-19

    申请号：US12255603

    申请日：2008-10-21

    申请人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    发明人： Karl W. Mollison ,  Angela M. LeCaptain ,  Sandra E. Burke ,  Keith R. Cromack ,  Peter J. Tarcha ,  Yen-Chih J. Chen ,  John L. Toner

    IPC分类号： A61F2/04 ,  A61K31/436 ,  A61K31/565

    CPC分类号： C07D498/18 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/254 ,  A61L2300/40 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/606

    摘要： A medical device comprising a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. Drugs that are suitable for use in this invention include, but are not limited to Formula (I). This drug can be used in combination with another drug including those selected from anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these drugs.

    摘要翻译： 一种医疗装置，包括能够容纳或支持药学上可接受的载体或赋形剂的载体或赋形剂的载体或赋形剂，所述载体或赋形剂可以含有一种或多种治疗剂或物质，载体优选在其表面上包含涂层， 治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 适用于本发明的药物包括但不限于式（I）。 该药物可以与另一种药物组合使用，包括选自抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些药物的组合。

    Method Of Treating Disorders Using Compositions Comprising Zotarolimus And Paclitaxel
    60.
    发明申请
    Method Of Treating Disorders Using Compositions Comprising Zotarolimus And Paclitaxel 有权
    使用佐他莫司和紫杉醇组合治疗疾病的方法

    公开(公告)号：US20080213278A1

    公开(公告)日：2008-09-04

    申请号：US12034612

    申请日：2008-02-20

    申请人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

    发明人： Sandra E. Burke ,  Keith R. Cromack ,  Matthew Mack ,  John L. Toner

    IPC分类号： A61K39/395 ,  A61K31/4353 ,  A61P35/00 ,  A61P37/00 ,  A61K31/56

    CPC分类号： A61K31/337 ,  A61K31/4745 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61M31/002

    摘要： A system and compositions including zotarolimus and paclitaxel are disclosed, as well as methods of delivery, wherein the drugs have effects that complement each other. Medical devices are disclosed which include supporting structures that include at least one pharmaceutically acceptable carrier or excipient, which carrier or excipient can include one or more therapeutic agents or substances, with the carrier including at least one coating on the surface thereof, and the coating associated with the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature. These compositions and systems can be used in combination with other drugs, including anti-proliferative agents, anti-platelet agents, anti-inflammatory agents, anti-thrombotic agents, cytotoxic drugs, agents that inhibit cytokine or chemokine binding, cell de-differentiation inhibitors, anti-lipaedemic agents, matrix metalloproteinase inhibitors, cytostatic drugs, or combinations of these and other drugs.

    摘要翻译： 公开了包含唑他罗莫司和紫杉醇的系统和组合物，以及递送方法，其中药物具有彼此补充的效果。 公开了包括至少一种药学上可接受的载体或赋形剂的载体结构的医疗装置，该载体或赋形剂可以包括一种或多种治疗剂或物质，载体包括其表面上的至少一层，并且涂层相关 与治疗物质，例如药物。 适用于本发明的医疗装置的支撑结构包括但不限于冠状支架，外周支架，导管，动静脉移植物，旁路移植物和用于脉管系统中的药物递送球囊。 这些组合物和系统可以与其它药物组合使用，包括抗增殖剂，抗血小板剂，抗炎剂，抗血栓形成剂，细胞毒性药物，抑制细胞因子或趋化因子结合的药物，细胞去分化抑制剂 ，抗脂血症药，基质金属蛋白酶抑制剂，细胞抑制药物或这些和其他药物的组合。