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公开(公告)号：US06492423B1
公开(公告)日：2002-12-10
申请号：US09744795
申请日：2001-01-26
IPC分类号： A01N3710
CPC分类号： C07D207/337 , A61K31/192 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/4192 , A61K31/42 , A61K31/4402 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/472 , A61K31/4725 , C07C59/76 , C07C59/90 , C07D211/34 , C07D211/96 , C07D213/30 , C07D213/89 , C07D249/18 , C07D249/20 , C07D261/12 , C07D307/80 , C07D333/28 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/60 , C07D333/74 , C07D401/12 , C07D409/04 , C07D495/04 , Y02A50/465
摘要： Diketoacids of Formula (A) are useful as inhibitors of viral polymerases. In particular hepatitis C virus RNA dependent RNA polymerase (HCV RdRp), hepatitis B virus polymerase (HBV pol) and reverse transcriptase of human immunodeficiency virus (HIV RN.) The group R may be broadly chosen and is an organic moiety which contains 2 to 24 carbon atoms and includes an optionally cyclic or heterocyclic group in which the atom directly bonded to the adjacent carbonyl in the diketoacid is part of the ring structure.
摘要翻译： 式（A）的二酮酸可用作病毒聚合酶的抑制剂。 特别是丙型肝炎病毒RNA依赖性RNA聚合酶（HCV RdRp），乙型肝炎病毒聚合酶（HBV pol）和人类免疫缺陷病毒（HIV RN。）的逆转录酶。R基团可以广泛选择，并且是含有2〜 24个碳原子，并且包括任选的环状或杂环基团，其中直链键合在二酮酸中的相邻羰基的原子是环结构的一部分。
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公开(公告)号：US5602953A
公开(公告)日：1997-02-11
申请号：US199834
申请日：1994-02-22
申请人： Peter Delage , Uwe Koch , Peter Zamzow , Klaus Nothofer
发明人： Peter Delage , Uwe Koch , Peter Zamzow , Klaus Nothofer
CPC分类号： G02B6/4403 , G02B6/4404 , G02B6/4416 , H01B11/22
摘要： A communication cable includes a plurality of strands that are interconnected by cross pieces which can be easily separated from each other such that each strand can be used as independent cables. At least one strand of the communication cable includes at least one electrical communication line and at least one optical communication line.
摘要翻译： 通信电缆包括通过十字片互连的多个线束，其可以容易地彼此分离，使得每个线束可以用作独立电缆。 通信电缆的至少一条链包括至少一个电通信线路和至少一个光通信线路。
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公开(公告)号：US20120306160A1
公开(公告)日：2012-12-06
申请号：US13487971
申请日：2012-06-04
申请人： Uwe Koch , Martin Schuster , Walter Schuhmacher
发明人： Uwe Koch , Martin Schuster , Walter Schuhmacher
CPC分类号： F16J15/46 , F16J15/3228 , F16J15/48
摘要： A radial shaft seal is provided for sealing between high and low pressure sides in an annular space between a shaft and a static structural receiving part, wherein the shaft seal is rotationally symmetric and arranged coaxially to the shaft. A first sealing ring has an inner periphery bulging toward the low pressure side and forms a first sealing lip abutting the shaft. A spacer ring has first and second faces directed towards the high and low pressure sides, respectively. An elastic shaped part has an outer periphery abutting the second face of the spacer ring and an inner periphery bulging toward the high pressure side and abutting the first sealing lip. At least the spacer ring and elastic shaped part define a cavity subjected to the high pressure side or a control pressure which presses the first sealing lip against the shaft via the elastic shaped part.
摘要翻译： 提供径向轴密封件，用于在轴和静态结构接收部分之间的环形空间中的高压侧和低压侧之间进行密封，其中所述轴密封件是旋转对称的并且与所述轴同轴布置。 第一密封环具有朝向低压侧凸出的内周边并且形成邻接轴的第一密封唇。 间隔环分别具有朝向高压侧和低压侧的第一和第二面。 弹性成型部具有与隔离环的第二面邻接的外周和向高压侧突出的内周，并抵靠第一密封唇。 至少隔离环和弹性形状部分限定经受高压侧的空腔或通过弹性成形部将第一密封唇压靠在轴上的控制压力。
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公开(公告)号：US20090312241A1
公开(公告)日：2009-12-17
申请号：US12306137
申请日：2007-06-21
申请人： Benedetta Crescenzi , Monica Donghi , Marco Ferrara , Cristina Gardelli , Steven Harper , Uwe Koch , Michael Rowley , Vincenzo Summa
发明人： Benedetta Crescenzi , Monica Donghi , Marco Ferrara , Cristina Gardelli , Steven Harper , Uwe Koch , Michael Rowley , Vincenzo Summa
CPC分类号： C07K5/0827 , C07K5/0806 , C07K5/0808 , C07K5/0812
摘要： The present invention relates to macrocyclic compounds of formula (I): wherein W, n, m, R1, R2, R3, R4, R5, Ra, M, Z and ring B are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
摘要翻译： 本发明涉及式（I）的大环化合物：其中W，n，m，R1，R2，R3，R4，R5，Ra，M，Z和环B在本文中定义，及其药学上可接受的盐，药物组合物 包括它们，以及它们用于治疗或预防丙型肝炎病毒感染的用途。
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公开(公告)号：US20090240425A1
公开(公告)日：2009-09-24
申请号：US11942141
申请日：2007-11-19
申请人： Wilfried Steins , Bernd Biechele , Marcello Tava , Uwe Koch
发明人： Wilfried Steins , Bernd Biechele , Marcello Tava , Uwe Koch
CPC分类号： G01C21/367
摘要： In the case of a system for marking a region within an image of a road map detail displayed on a vehicle video screen, the regions are shown in a circular shape. The center and the dimensions of the region can be changed by a control element, which can be rotated about a longitudinal axis and can be deflected transversely to the longitudinal axis. As a result of the transverse movement of the control element, the position of the center point and, as a result of the rotating movement of the control element, the dimensions of the region within the video screen, are adjustable.
摘要翻译： 在车辆视频屏幕上显示的道路地图细节的图像内的区域标记系统的情况下，以圆形显示该区域。 该区域的中心和尺寸可以通过控制元件来改变，该控制元件可以围绕纵向轴线旋转并且可以横向于纵向轴线偏转。 作为控制元件横向移动的结果，中心点的位置以及作为控制元件的旋转运动的结果，视频屏幕内的区域的尺寸是可调节的。
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