TECHNIQUES AND DEVICES FOR ADAPTATION OF MAXIMUM DRUG DELIVERY LIMITS

    公开(公告)号:US20220249773A1

    公开(公告)日:2022-08-11

    申请号:US17665165

    申请日:2022-02-04

    Abstract: Disclosed are techniques, a system and devices that enable the setting of an upper boundary constraint that may be a multiple of a total daily dosage setting for a liquid drug being administered to a user to control a condition, such as type 1 or type 2 diabetes mellitus. An automatic drug delivery algorithm may be configured to obtain a glucose control metric. A controller executing the automatic drug delivery algorithm may ascertain, based on the glucose control metric, an upper boundary constraint for the liquid drug that limits an amount of a dose of the liquid drug that may be delivered by the automatic drug delivery system or components thereof.

    COMPENSATION FOR MISSING READINGS FROM A GLUCOSE MONITOR IN AN AUTOMATED INSULIN DELIVERY SYSTEM

    公开(公告)号:US20220226576A1

    公开(公告)日:2022-07-21

    申请号:US17715589

    申请日:2022-04-07

    Abstract: Exemplary embodiments may address the problem of missing blood glucose concentration readings from a glucose monitor that transmits blood glucose concentration readings over a wireless connection due to problems with the wireless connection. In the exemplary embodiments, an automated insulin delivery (AID) device uses an estimate in place of a missing blood glucose concentration reading in determining a predicted future blood glucose concentration reading for a user. Thus, the AID device is able to operate normally in generating insulin delivery settings despite not receiving a current blood glucose concentration reading for a current cycle. There is no need to suspend delivery of insulin to the user due to the missing blood glucose concentration reading.

    TECHNIQUES FOR DETERMINING INSULIN FORMULATIONS IN AN AUTOMATED INSULIN DELIVERY SYSTEM

    公开(公告)号:US20220062545A1

    公开(公告)日:2022-03-03

    申请号:US17008054

    申请日:2020-08-31

    Abstract: Techniques and devices for determining and generating insulin formulations are described. An automated insulin delivery device may include a wireless interface with a glucose sensor for providing blood glucose concentration readings of a user, a plurality of insulin reservoirs, each of the plurality of insulin reservoirs holding a different one of a plurality of insulin types, each of the plurality of insulin types having a different strength, a storage medium storing programming instructions and user glucose information, the user glucose information comprising the blood glucose concentration readings, predicted future blood glucose concentration readings, and user activity information, determining an insulin strength based on the user glucose information, determining an insulin formulation ratio to generate an insulin formulation having the insulin strength using the plurality of insulin types, an insulin formulation device to generate the insulin formulation; and an insulin delivery component to deliver the insulin formulation to the user.

    TECHNIQUES FOR IMAGE-BASED MONITORING OF BLOOD GLUCOSE STATUS

    公开(公告)号:US20220061706A1

    公开(公告)日:2022-03-03

    申请号:US17003854

    申请日:2020-08-26

    Abstract: Methods and apparatuses for performing a blood glucose monitoring process are described. For example, an apparatus may include at least one memory and logic coupled to the at least one memory. The logic may operate to determine patient monitoring information associated with a diabetic treatment of a patient, generate at least one monitoring information structure based on the patient monitoring information, generate at least one monitoring information image based on at least a portion of the at least one monitoring information structure, and process the at least one monitoring information image using a computational model to determine a blood glucose condition of the patient. Other embodiments are described.

    MEAL BOLUS SUBCATEGORIES IN MODEL BASED INSULIN THERAPY

    公开(公告)号:US20210259590A1

    公开(公告)日:2021-08-26

    申请号:US16796575

    申请日:2020-02-20

    Abstract: Disclosed are examples that include receiving information related to ingestion of a meal. The information may include a coarse indication of a size of the meal, a relative time of ingestion of the meal, and a general composition indication of the meal. A blood glucose measurement value received within a predetermined time range of a relative time of ingestion of the meal may be identified. Settings for a delay and an extend parameter and a delivery constraint may be determined. A meal model may be modified using the determined settings for the delay parameter, the extend parameter, and the delivery constraint. The modified meal model may be used to determine a dose of insulin to be delivered in response to the received information. An instruction indicates a determined dose of insulin to be delivered may be output for delivery to a drug delivery device.

    COMPENSATION FOR MISSING READINGS FROM A GLUCOSE MONITOR IN AN AUTOMATED INSULIN DELIVERY SYSTEM

    公开(公告)号:US20210252219A1

    公开(公告)日:2021-08-19

    申请号:US16791648

    申请日:2020-02-14

    Abstract: Exemplary embodiments may address the problem of missing blood glucose concentration readings from a glucose monitor that transmits blood glucose concentration readings over a wireless connection due to problems with the wireless connection. In the exemplary embodiments, an automated insulin delivery (AID) device uses an estimate in place of a missing blood glucose concentration reading in determining a predicted future blood glucose concentration reading for a user. Thus, the AID device is able to operate normally in generating insulin delivery settings despite not receiving a current blood glucose concentration reading for a current cycle. There is no need to suspend delivery of insulin to the user due to the missing blood glucose concentration reading.

    MEAL INSULIN DETERMINATION FOR IMPROVED POST PRANDIAL RESPONSE

    公开(公告)号:US20210228804A1

    公开(公告)日:2021-07-29

    申请号:US17150461

    申请日:2021-01-15

    Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide techniques to implement functionality to receive information related to a meal and delivery of a meal bolus. The received information may be stored and utilized in the generation of insulin delivery profiles. An estimate a mealtime insulin need based on the generated insulin delivery profiles may be generated. A dose of insulin may be determined that satisfies an estimated mealtime insulin need based on the generated insulin delivery profiles. The determined dose of insulin may be output at a time corresponding to a mealtime.

    TECHNIQUES FOR IMPROVED AUTOMATIC DRUG DELIVERY PERFORMANCE USING DELIVERY TENDENCIES FROM PAST DELIVERY HISTORY AND USE PATTERNS

    公开(公告)号:US20210187196A1

    公开(公告)日:2021-06-24

    申请号:US17123369

    申请日:2020-12-16

    Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide techniques to implement functionality to receive blood glucose measurements over a period of time. An average of missing blood glucose measurement values may be maintained over a predetermined time period. A count of a number of missing blood glucose measurement values over a period of time may be established. A controller may calculate a divergence of the number of missing blood glucose measurement values over the period of time from the average of missing blood glucose measurements over the predetermined time period. Based on a value of the divergence, a determination that a safety constraint for delivery of insulin is to be reduced. The safety constraint may be reduced by a predetermined percentage. An instruction to deliver an insulin dosage may be generated according to the reduced safety constraint may be forwarded to a wearable drug delivery device.

    BLOOD GLUCOSE RATE OF CHANGE MODULATION OF MEAL AND CORRECTION INSULIN BOLUS QUANTITY

    公开(公告)号:US20210077719A1

    公开(公告)日:2021-03-18

    申请号:US16570125

    申请日:2019-09-13

    Abstract: Disclosed are a system, methods and computer-readable medium products that provide bolus dosage calculations by a control algorithm-based drug delivery system that provides automatic delivery of a drug, such as insulin or the like, based on sensor input. Blood glucose measurement values may be received at regular time intervals from a sensor. Using the blood glucose measurements, the control algorithm may perform various calculations and determinations to provide an appropriate bolus dosage. The appropriate bolus dosage may be used to respond to a trend in a trajectory of blood glucose measurements. In addition, a bolus dosage may also be determined by the disclosed device, system, method and/or computer-readable medium product in response to an indication that a user consumed a meal.

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