公开(公告)号：US06720177B2

公开(公告)日：2004-04-13

申请号：US09795533

申请日：2001-02-28

申请人： M. Reza Ghadiri ,  Michael J. Sailor ,  Kianoush Motesharei ,  Shang-Yi Lin ,  Keiki-Pua S. Dancil

发明人： M. Reza Ghadiri ,  Michael J. Sailor ,  Kianoush Motesharei ,  Shang-Yi Lin ,  Keiki-Pua S. Dancil

IPC分类号： G01N33543

CPC分类号： G01N21/45 ,  G01N33/5438 ,  G01N2021/458 ,  Y10S435/808 ,  Y10S435/973 ,  Y10S436/805

摘要： The measurement of the wavelength shifts in the reflectometric interference spectra of a porous semiconductor substrate such as silicon, make possible the highly sensitive detection, identification and quantification of small analyte molecules. The sensor of the subject invention is effective in detecting multiple layers of biomolecular interactions, termed “cascade sensing”, including sensitive detection of small molecule recognition events that take place relatively far from the semiconductor surface.

摘要翻译： 多孔半导体衬底（如硅）的反射干涉光谱中波长偏移的测量使得可以对小分析物分子进行高灵敏度的检测，鉴定和定量。 本发明的传感器有效地检测称为“级联感测”的多层生物分子相互作用，包括敏感地检测相对远离半导体表面的小分子识别事件。