公开(公告)号：US5851547A

公开(公告)日：1998-12-22

申请号：US762847

申请日：1996-12-10

申请人： Keiji Fujioka ,  Takeshi Hirasawa ,  Masako Kajihara ,  Akihiko Sano ,  Shuichi Sugawara ,  Yosuke Urabe

发明人： Keiji Fujioka ,  Takeshi Hirasawa ,  Masako Kajihara ,  Akihiko Sano ,  Shuichi Sugawara ,  Yosuke Urabe

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/24

CPC分类号： A61K9/0092

摘要： A drug formulation for producing sustained therapeutic efficacy, which releases at least one water-soluble drug over a prolonged period of time at a substantially constant rate wherein said drug formulation comprises (a) a nondisintegrating inner layer comprised of a biocompatible material that contains at least one uniformly dispersed water-soluble drug; and (b) an outer layer comprised of a biocompatible material that surrounds the circumference of the said inner layer, is impermeable to water, and is capable of controlling the swelling of the inner layer; wherein the ratio of the axial length of the drug formulation to the cross-sectional diameter of the inner layer is one or more and wherein one or both ends of the inner layer are open so as to come into direct contact with the external environment.

摘要翻译： 一种用于产生持续治疗功效的药物制剂，其以基本恒定的速率在长时间内释放至少一种水溶性药物，其中所述药物制剂包含（a）由生物相容性材料组成的非整合内层，所述生物相容性材料至少包含 一种均匀分散的水溶性药物; 和（b）由围绕所述内层的圆周的生物相容性材料构成的外层，不透水，并且能够控制内层的膨胀; 其中所述药物制剂的轴向长度与所述内层的横截面直径的比率是一个或多个，并且其中所述内层的一端或两端是敞开的，以便与外部环境直接接触。