公开(公告)号：US5919924A

公开(公告)日：1999-07-06

申请号：US849393

申请日：1997-06-03

申请人： Michio Sasaoka ,  Shigeru Torii ,  Hideo Tanaka ,  Ryo Kikuchi ,  Yutaka Kameyama ,  Kouichi Sorajo

发明人： Michio Sasaoka ,  Shigeru Torii ,  Hideo Tanaka ,  Ryo Kikuchi ,  Yutaka Kameyama ,  Kouichi Sorajo

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  B01J27/055 ,  B01J27/122 ,  B01J31/20 ,  C07B61/00 ,  C07D501/00 ,  C07D501/08 ,  C07D501/18 ,  C07D501/59

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： A process for preparing a 3-halogenated cephem derivative represented by the formula (2), characterized by causing a halogenating reagent to act on an allenyl .beta.-lactam compound represented by the formula (1) in the presence of a cuprous salt or cupric salt to obtain the 3-halogenated cephem derivative ##STR1## wherein R.sup.1 is a hydrogen atom, amino or protected amino, R.sup.2 is a hydrogen atom, halogen atom, lower alkoxyl, lower acyl, lower alkyl, lower alkyl having at least one selected from hydroxyl and protected hydroxyl as a substituent, hydroxyl or protected hydroxyl, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, R.sup.4 is an aromatic compound residue which may have a substituent or nitrogen-containing aromatic heterocyclic compound residue which may have a substituent, and n is 0 to 2 ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, X is a halogen atom.

摘要翻译： PCT No.PCT / JP96 / 03298 Sec。 371日期：1997年6月3日 102（e）日期1997年6月3日PCT 1996年11月8日PCT公布。 第WO97 / 17353号公报 日期：1997年5月5日制备式（2）表示的3-卤代头孢烯衍生物的方法，其特征在于，使卤化剂作用于由式（1）表示的丙烯酰基β-内酰胺化合物， 盐或铜盐，得到其中R 1为氢原子，氨基或被保护的氨基，R 2为氢原子，卤素原子，低级烷氧基，低级酰基，低级烷基，具有选自以下的至少一种的低级烷基的3-卤代头孢烯衍生物 羟基和保护的羟基作为取代基，羟基或被保护的羟基，R3是氢原子或羧酸保护基，R4是可以具有取代基的芳族化合物残基或可以具有取代基的含氮芳族杂环化合物残基，以及 n为0〜2，其中R1，R2和R3如上所定义，X为卤素原子。

公开(公告)号：US5247054A

公开(公告)日：1993-09-21

申请号：US561643

申请日：1990-08-01

申请人： Hitoshi Tanaka ,  Tsuneyuki Sato ,  Todatoshi Ota, deceased ,  Michio Sasaoka

发明人： Hitoshi Tanaka ,  Tsuneyuki Sato ,  Todatoshi Ota, deceased ,  Michio Sasaoka

IPC分类号： C08F2/58 ,  C08F2/00 ,  C08G61/00 ,  H01F1/42

CPC分类号： H01F1/42 ,  C08G61/00

摘要： An organic polymer ferromagnetic material characterized in that the material comprises a polymer obtained by subjecting to plasma polymerization or oxidation polymerization a methane derivative having two substituents and represented by the formula ##STR1## wherein A is an electron accepting group, and B is an electron donating group, or by copolymerizing the methane derivative with a diarylmethane derivative represented by the formula ##STR2## wherein R.sup.1 is a substituted or unsubstituted phenyl group by plasma polymerization or oxidation polymerization.

公开(公告)号：US4740596A

公开(公告)日：1988-04-26

申请号：US089947

申请日：1987-08-26

申请人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Shigemitsu Nagao

发明人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Shigemitsu Nagao

IPC分类号： C07D205/08 ,  A61K31/395 ,  A61K31/397 ,  A61P31/04 ,  C07D205/09 ,  C07D205/095 ,  C07D417/12 ,  C07B45/00 ,  C07D401/12

CPC分类号： C07D205/09 ,  C07D205/095

摘要： A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formulaR.sup.3 SO.sub.2 SR.sup.9 (VII)wherein R.sup.3 and R.sup.9 are as defined above.

摘要翻译： 制备式（I）表示的氮杂环丁酮衍生物的方法，其中R 1是氢，卤素或低级烷氧基，R 2是氢，卤素，低级烷氧基，氨基或基团（其中R 5是取代的或 未取代的苯基，取代或未取代的苯基甲基，取代或未取代的苯氧基甲基或取代或未取代的苯甲酰基），或R 1和R 2一起为羰基，R 3为取代或未取代的苯基，且R 4为氢，任选取代的烃残基或酰基 ，衍生自无机酸或有机酸的甲硅烷基，磺酰基或膦酰基，该方法包括使由式（VI）表示的二硫代氮杂环丁酮衍生物（其中R 1，R 2和R 4如上所定义）和R 9是取代或未取代的， 含有由式R3SO2SR9（VII）表示的化合物的芳族杂环残基，其中R3和R9如上定义。

公开(公告)号：US4713452A

公开(公告)日：1987-12-15

申请号：US680723

申请日：1984-12-12

申请人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Seiryu Uto ,  Syozo Hayase

发明人： Sigeru Torii ,  Hideo Tanaka ,  Michio Sasaoka ,  Seiryu Uto ,  Syozo Hayase

IPC分类号： C07D205/08 ,  A61K31/395 ,  A61K31/397 ,  A61P31/04 ,  C07D205/09 ,  C07D205/095 ,  C07D417/12 ,  C07B45/00 ,  C07F7/10 ,  C07F9/65

CPC分类号： C07D205/09 ,  C07D205/095

摘要： A process for preparing an azetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is hydrogen, halogen or lower alkoxy, R.sup.2 is hydrogen, halogen, lower alkoxy, amino or a group ##STR2## (in which R.sup.5 is substituted or unsubstituted phenyl, substituted or unsubstituted phenylmethyl, substituted or unsubstituted phenoxymethyl, or substituted or unsubstituted benzoyl), or R.sup.1 and R.sup.2, when taken together, are carbonyl, R.sup.3 is substituted or unsubstituted phenyl, and R.sup.4 is hydrogen, optionally substituted hydrocarbon residue or acyl, silyl, sulfonyl or phosphonyl derived from inorganic acid or organic acid, the process comprising reacting a dithioazetidinone derivative represented by the formula ##STR3## wherein R.sup.1, R.sup.2 and R.sup.4 are as defined above and R.sup.9 is substituted or unsubstituted, nitrogen-containing aromatic heterocyclic residue with a compound represented by the formulaR.sup.3 SO.sub.2 CN (VII)wherein R.sup.3 is defined above.

摘要翻译： 制备式（I）表示的氮杂环丁酮衍生物的方法，其中R 1是氢，卤素或低级烷氧基，R 2是氢，卤素，低级烷氧基，氨基或基团（其中R 5是取代的或 未取代的苯基，取代或未取代的苯基甲基，取代或未取代的苯氧基甲基或取代或未取代的苯甲酰基），或R 1和R 2一起为羰基，R 3为取代或未取代的苯基，且R 4为氢，任选取代的烃残基或酰基 ，衍生自无机酸或有机酸的甲硅烷基，磺酰基或膦酰基，该方法包括使由式（VI）表示的二硫代氮杂环丁酮衍生物（其中R 1，R 2和R 4如上所定义）和R 9是取代或未取代的， 含有由式R 3 SO 2 CN（Ⅶ）表示的化合物的芳族杂环残基，其中R 3如上定义。