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51.发明授权Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom 失效3-（胍基羰基）杂环的衍生物，其制备方法及其中间体，其作为药物的用途及其药物组合物公开(公告)号：US07230007B2
公开(公告)日：2007-06-12
申请号：US10865454
申请日：2004-06-10
申请人： Jean-Christophe Carry , Gilles Doerflinger , Arielle Genevois-Borella , Michel Evers , Alain Le Brun , Jean-Paul Martin , Pascal Desmazeau , Serge Mignani , Heinz-Werner Kleemann
发明人： Jean-Christophe Carry , Gilles Doerflinger , Arielle Genevois-Borella , Michel Evers , Alain Le Brun , Jean-Paul Martin , Pascal Desmazeau , Serge Mignani , Heinz-Werner Kleemann
IPC分类号： A61K31/44 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.
摘要翻译： 本发明公开并要求式I化合物及其药学上可接受的盐，以及使用所述式I化合物单独或与其它药物组合的抗心律失常药物与预防或治疗梗死的心脏保护组分的方法，用于 心绞痛的治疗以及与局部缺血诱导的损伤发展相关的病理生理过程的抑制剂，特别是引发缺血诱导的心律失常和心力衰竭。 包含式I化合物或式I化合物与一种或多种其它药物组合的药物组合物和式I化合物的制备方法也被公开并要求保护。
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公开(公告)号：US20060148880A1
公开(公告)日：2006-07-06
申请号：US11365319
申请日：2006-03-01
申请人： Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
发明人： Heinz-Werner Kleemann , Armin Hofmeister , Jean-Christophe Carry , Baptiste Ronan , Serge Mignani , Antony Bigot
IPC分类号： A61K31/4035 , C07D403/02 , C07D209/46
CPC分类号： C07D209/46
摘要： The present invention relates to the novel isoindolone derivatives of the formula I in which R1 to R6 have the meanings stated in the claims. The inventive compounds are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also inhibit in a preventive manner the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.
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53.发明授权Arylated furan- and thiophenecarboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them 失效甲酰化呋喃和噻吩甲酰胺，它们的制备方法，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US06982279B2
公开(公告)日：2006-01-03
申请号：US10012338
申请日：2001-12-12
IPC分类号： A61K31/38 , A61K31/34 , C07D333/38 , C07D307/02
CPC分类号： C07D333/38 , A61K31/34 , A61K31/38 , C07D307/68 , A61K2300/00
摘要： Compounds of the formulae IA and Ib. in which X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), R(30) and R(31) have the meanings indicated in the claims, are very particularly suitable as novel antiarrhythmic active compounds, in particular for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters.
摘要翻译： 式IA和Ib的化合物。 其中X，R（1），R（2），R（3），R（4），R（5），R（6），R（7），R（30）和R 权利要求中指出的含义特别适合作为新的抗心律失常活性化合物，特别是用于治疗和预防心房心律失常，例如 心房颤动（AF）或心房扑动。
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54.发明申请Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates 有权正构取代的五氟硫基苯，其制备方法及其作为有价值的合成中间体的用途公开(公告)号：US20050148652A1
公开(公告)日：2005-07-07
申请号：US10989027
申请日：2004-11-15
申请人： Heinz-Werner Kleemann , Remo Weck
发明人： Heinz-Werner Kleemann , Remo Weck
IPC分类号： C07C381/00 , A61K31/405 , A61K31/277 , C07C39/88
CPC分类号： C07C381/00
摘要： Pentafluorosulfanyl-benzenes according to Formula (I): a process for their preparation and their use as valuable synthetic intermediates for preparing, for example, medicaments, diagnostic aids, liquid crystals, polymers, pesticides, herbicides, fungicides, nematicides, parasiticides, insecticides, acaricides and arthropodicides.
摘要翻译： 根据式（I）的五氟硫烷基 - 苯：其制备方法及其用作制备例如药物，诊断助剂，液晶，聚合物，农药，除草剂，杀真菌剂，杀线虫剂，杀寄生虫剂，杀虫剂， 杀螨剂和节肢动物杀虫剂。
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55.发明申请Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives 有权制备（3-氧代-2,3-二氢-1H-异吲哚-1-基）乙酰基胍衍生物的方法公开(公告)号：US20050124681A1
公开(公告)日：2005-06-09
申请号：US11001624
申请日：2004-12-01
申请人： Gerrit Schubert , Joerg Rieke-Zapp , Johannes Keil , Heinz-Werner Kleemann , Reda Hanna , Bao-Guo Huang , Xiao-Dong Wu , Yves Gouraud
发明人： Gerrit Schubert , Joerg Rieke-Zapp , Johannes Keil , Heinz-Werner Kleemann , Reda Hanna , Bao-Guo Huang , Xiao-Dong Wu , Yves Gouraud
IPC分类号： A61K31/4035 , C07D209/46
CPC分类号： A61K31/4035
摘要： A method and apparatus for preventing board warpage during the application and curing or drying of liquid epoxies, or the like, on printed circuit boards using a clamping fixture assembly, which includes at least one clamping fixture support and at least one clamping fixture overlay. If desired, a plurality of printed circuit boards may be processed using an appropriate clamping fixture assembly. Furthermore, the clamping fixture may be constructed so a slight bow or curvature thereof can counter either a convex or concave bow or curvature of the printed circuit board. In the method, at least one printed circuit board is mounted to a clamping fixture support whereby a clamping fixture overlay is placed on top of the first printed circuit board.
摘要翻译： 一种用于在使用夹紧夹具组件的印刷电路板上施加和固化或干燥液体环氧树脂等期间防止板翘曲的方法和装置，其包括至少一个夹紧夹具支架和至少一个夹紧固定盖。 如果需要，可以使用适当的夹具组件来处理多个印刷电路板。 此外，夹持夹具可以被构造成轻微的弓形或其曲率可以对抗印刷电路板的凸形或凹形弓形或曲率。 在该方法中，至少一个印刷电路板安装到夹具固定支架上，由此夹紧夹具覆盖物放置在第一印刷电路板的顶部上。
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56.发明授权Fluorinated cycloalkyl-derivatized benzoylguanidines, process for their preparation, their uses as medicament, and medicament containing them 失效氟化环烷基衍生化苯甲酰胍，其制备方法，它们作为药物的用途以及含有它们的药物公开(公告)号：US06878748B2
公开(公告)日：2005-04-12
申请号：US10452556
申请日：2003-06-02
IPC分类号： A61K31/155 , A61K31/165 , C07C277/10 , C07C277/20
CPC分类号： C07C317/46 , C07C317/48 , C07C2601/04
摘要： Fluorinated cycloalkyl-derivatized benzoylguanidines of formula I are suitable as antiarrhythmic medicaments with a cardioprotective component for infarction prophylaxis and infarction treatment and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure.
摘要翻译： 式I的氟化环烷基衍生化苯甲酰胍具有适合作为抗心律失常药物，具有用于梗死预防和梗塞治疗的心脏保护成分，用于治疗心绞痛。还预防性地抑制与缺血诱发的损伤发展有关的病理生理过程，特别是 引发缺血诱导的心律失常和心力衰竭。
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57.发明申请Derivatives of 3-(guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom 失效3-（胍基羰基）杂环的衍生物，其制备方法及其中间体，它们作为药物的用途及其药物组合物公开(公告)号：US20050014758A1
公开(公告)日：2005-01-20
申请号：US10865454
申请日：2004-06-10
申请人： Jean-Christophe Carry , Gilles Doerflinger , Arielle Genevois-Borella , Michel Evers , Alain Le Brun , Jean-Paul Martin , Pascal Desmazeau , Serge Mignani , Heinz-Werner Kleemann
发明人： Jean-Christophe Carry , Gilles Doerflinger , Arielle Genevois-Borella , Michel Evers , Alain Le Brun , Jean-Paul Martin , Pascal Desmazeau , Serge Mignani , Heinz-Werner Kleemann
IPC分类号： C07D471/04 , C07D471/02 , A61K31/4745 , A61K31/503 , A61K31/519 , C07D487/02
CPC分类号： C07D471/04
摘要： The present invention discloses and claims compounds of formula I and their pharmaceutically acceptable salts, and methods of using said compounds of formula I, either alone or in combination with other medicaments, as antiarrhythmic medicaments with a cardioprotective component for prophylaxis or treatment of infarction, for the treatment of angina pectoris, and as inhibitors of pathophysiological processes associated with the development of ischemia-induced damage, in particular in the triggering of ischemia-induced cardiac arrhythmias and of heart failure. Pharmaceutical compositions comprising compounds of formula I or compounds of formula I in combination with one or more other medicaments and processes for the preparation of compounds of formula I are also disclosed and claimed.
摘要翻译： 本发明公开并要求式I化合物及其药学上可接受的盐，以及使用所述式I化合物单独或与其它药物组合的抗心律失常药物与预防或治疗梗死的心脏保护组分的方法，用于 心绞痛的治疗以及与局部缺血诱导的损伤发展相关的病理生理过程的抑制剂，特别是引发缺血诱导的心律失常和心力衰竭。 包含式I化合物或式I化合物与一种或多种其它药物组合的药物组合物和式I化合物的制备方法也被公开并要求保护。
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58.发明授权Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparation comprising them 失效邻位取代的含氮双芳基化合物，其制备方法，它们作为药物的用途，以及包含它们的药物制剂公开(公告)号：US06794377B2
公开(公告)日：2004-09-21
申请号：US10002326
申请日：2001-12-05
IPC分类号： A61K3133
CPC分类号： C07D213/81 , C07D213/56 , C07D213/82 , C07D241/24 , C07D401/12 , C07D413/12
摘要： Ortho, ortho-substituted nitrogen-containing bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters. Compounds of the invention include compounds of the formula I
摘要翻译： 邻位取代的含氮双芳基化合物，其制备方法，它们作为药物的用途，以及药物制剂，包括它们作为抗心律失常活性化合物的用途，例如用于治疗和预防心房心律失常，例如， 心房颤动（AF）或心房扑动。 本发明的化合物包括式I的化合物
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59.发明授权Mercaptoacetylamide derivatives, a process for their preparation and their use 有权巯基乙酰胺衍生物，其制备方法及其用途公开(公告)号：US06602866B2
公开(公告)日：2003-08-05
申请号：US10118179
申请日：2002-04-08
申请人： Gary A. Flynn , Barbara A. Anderson , Manfred Gerken , Bernd Jablonka , Heinz-Werner Kleemann , Wolfgang Linz , Werner Seiz , Bernhard Seuring
发明人： Gary A. Flynn , Barbara A. Anderson , Manfred Gerken , Bernd Jablonka , Heinz-Werner Kleemann , Wolfgang Linz , Werner Seiz , Bernhard Seuring
IPC分类号： A61K3155
CPC分类号： C07D471/04
摘要： This invention discloses and claims a series of mercaptoacetylamide derivatives of formula I. Also disclosed and claimed are pharmaceutical compositions incorporating these compounds and processes for preparing said compounds. The use of said compounds for inhibition of the enzymes angiotensin converting enzyme and neutral endopeptidase, and for the treatment of hypertension and congestive heart failure are also disclosed and claimed
摘要翻译： 本发明公开并要求一系列式I的巯基乙酰胺衍生物。还公开并要求保护的是掺入这些化合物的药物组合物和制备所述化合物的方法。 所述化合物用于抑制酶血管紧张素转化酶和中性肽链内切酶以及用于治疗高血压和充血性心力衰竭的用途也被公开并要求保护
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60.发明授权Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them 失效正离子取代的苯甲酰胍，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物
公开(公告)号：US6153651A
公开(公告)日：2000-11-28
申请号：US808295
申请日：1997-02-28
申请人： Udo Albus , Joachim Brendel , Heinz-Werner Kleemann , Hans Jochen Lang , Wolfgang Scholz , Jan-Robert Schwark , Andreas Weichert
发明人： Udo Albus , Joachim Brendel , Heinz-Werner Kleemann , Hans Jochen Lang , Wolfgang Scholz , Jan-Robert Schwark , Andreas Weichert
IPC分类号： A61K31/165 , A01N1/02 , A61K31/155 , A61P9/00 , A61P9/08 , A61P9/10 , A61P35/00 , A61P43/00 , C07C279/22 , C07C233/64
CPC分类号： C07C279/22
摘要： Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them.Ortho-substituted benzoylguanidines of the formula I ##STR1## in which R(1) to R(4) have the meanings given in the claims, are suitable, as antiarrhythmic pharmaceuticals having a cardioprotective component, for the prophylaxis and treatment of infarction and for the treatment of angina pectoris. They also inhibit, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the triggering of ischemically induced cardiac arrhythmias.
摘要翻译： 正离子取代的苯甲酰胍，其制备方法，它们作为药物或诊断剂的用途，以及包含它们的药物。 其中R（1）至R（4）具有权利要求中给出的含义的式I的正取代的苯甲酰基胍适合作为具有心脏保护成分的抗心律失常药物用于预防和治疗梗死和治疗 心绞痛。 它们还以预防的方式抑制与缺血诱导的损伤的发生相关的病理生理过程，特别是与引发缺血诱导的心律失常有关。
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