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公开(公告)号：US4976966A
公开(公告)日：1990-12-11
申请号：US291725
申请日：1988-12-29
申请人： Felix Theeuwes , Patrick S. L. Wong
发明人： Felix Theeuwes , Patrick S. L. Wong
CPC分类号： A61K9/0004
摘要： An osmotically driven pump is provided that is capable of being miniaturized to a size suited for swallowing or implanting in an animal. The pump may be used to administer a drug in fluid form after an initial activation period during which substantially no drug is administered. The basic components of the pump are a shaped semipermeable membrane that encapsulates an osmotically effective solute and preferably a drug or other beneficial agent and a discharge port through which the drug or other beneficial agent is dispensed. A semipermeable or microporous outer cover surrounds the semipermeable membrane and seals it from an external aqueous environment. A water-swellable composition is operatively positioned between the end of the semipermeable membrane and the outer cover. Preferably, a water wicking layer at least partially surrounds the semipermeable membrane and is also sealed within the outer cover. In operation, the pump is placed in an aqueous environment. Water from the environment passes through the semipermeable/microporous portion of the outer cover into the water-swellable composition. The water-swellable composition absorbs water, expands, and in piston-like fashion displaces the outer cover, thereby exposing the semipermeable membrane to the aqueous environment and activating the osmotic pump. The time required for the water-swellable composition to absorb water, expand and displace the outer cover provides an initial activation period during which substantially no drug is delivered by the pump.
摘要翻译： 提供了一种渗透驱动的泵，其能够被小型化成适合于在动物中吞咽或植入的尺寸。 在基本上不施用药物的初始活化期之后，泵可以用于以流体形式施用药物。 泵的基本组分是封装渗透有效溶质，优选药物或其它有益剂的成形半透膜和药物或其它有益剂通过其分配的排出口。 半透膜或微孔外壳围绕半透膜并将其与外部水性环境密封。 可水膨胀组合物可操作地定位在半透膜的端部和外覆盖件之间。 优选地，吸水层至少部分地包围半透膜并且也被密封在外盖内。 在操作中，将泵放置在水性环境中。 来自环境的水通过外盖的半透/微孔部分进入水溶胀性组合物。 水溶胀性组合物吸收水，膨胀，并且以活塞样的方式取代外盖，从而将半透膜暴露于水性环境并激活渗透泵。 水溶胀性组合物吸收水，膨胀和置换外盖所需的时间提供初始激活期，在此期间基本上没有药物由泵输送。
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公开(公告)号：US4971790A
公开(公告)日：1990-11-20
申请号：US370313
申请日：1989-06-22
CPC分类号： A61M31/002 , A61K9/0004
摘要： A composition of matter comprising a drug, a neutral hydrogel and an ionic hydrogel. The composition can be administered from a delivery system to a biological receptor over time.
摘要翻译： 包含药物，中性水凝胶和离子水凝胶的物质组合物。 组合物可以随时间从递送系统施用于生物受体。
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公开(公告)号：US4966769A
公开(公告)日：1990-10-30
申请号：US350440
申请日：1989-05-11
CPC分类号： A61K9/0004 , A61K31/55
摘要： A device is disclosed for delivering diltiazem at a controlled and substantially zero order rate over a prolonged period of time.
摘要翻译： 公开了一种用于在长时间段内以受控且基本为零级速率输送硫氮的装置。
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公开(公告)号：US4948592A
公开(公告)日：1990-08-14
申请号：US313211
申请日：1989-02-21
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译： 一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。
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公开(公告)号：US4904474A
公开(公告)日：1990-02-27
申请号：US147840
申请日：1988-01-25
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A drug delivery device is disclosed for delivering a drug to the colon. The device comprises means for delaying the delivery of drug in the stomach, means for delaying delivery of drug in the small intestine, and means for delivering drug in the colon.
摘要翻译： 公开了用于将药物递送至结肠的药物递送装置。 该装置包括用于延迟药物在胃中的递送的装置，用于延迟药物在小肠中的递送的装置，以及用于在结肠中递送药物的装置。
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公开(公告)号：US4874388A
公开(公告)日：1989-10-17
申请号：US66906
申请日：1987-06-25
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser for use in a fluid environment having a rigid housing containing a fluid activated driving member, a plurality of drug containing layers and an outlet means by which drug is dispensed to the environment. The housing adjacent to the layers is fluid impermeable and the housing adjacent to the driving member is fluid permeable or has an open area by which fluid can contact the driving member. O048743884
摘要翻译： 一种在流体环境中使用的分配器，其具有容纳流体激活的驱动构件，多个药物容纳层的刚性壳体和药物分配到环境中的出口装置。 与层相邻的壳体是流体不可渗透的，并且与驱动构件相邻的壳体是流体可渗透的或具有开口区域，流体可以通过该开口区域接触驱动构件。 O048743884
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公开(公告)号：US4723957A
公开(公告)日：1988-02-09
申请号：US827027
申请日：1986-02-07
CPC分类号： A61K9/0004 , A61M31/002
摘要： A composition of matter comprising a drug, a neutral hydrogel and an ionic hydrogel. The composition can be administered from a delivery system to a biological receptor over time.
摘要翻译： 包含药物，中性水凝胶和离子水凝胶的物质组合物。 组合物可以随时间从递送系统施用于生物受体。
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公开(公告)号：US4627851A
公开(公告)日：1986-12-09
申请号：US665332
申请日：1984-10-26
申请人： Patrick S. L. Wong , Felix Theeuwes
发明人： Patrick S. L. Wong , Felix Theeuwes
CPC分类号： A61K9/0004 , Y10T428/31884
摘要： An osmotic device is disclosed for delivering a drug to the colon. The device comprises a laminated wall surrounding a compartment containing a drug with a passageway through the wall for dispensing the drug from the device. The laminated wall comprises three laminae, an inner semipermeable lamina, a middle lamina containing a salt of a fatty acid and an outer enteric lamina.
摘要翻译： 公开了用于将药物递送至结肠的渗透装置。 该装置包括围绕包含药物的隔室的层压壁，该隔室具有通过壁的通道，用于从该装置分配药物。 层压壁包括三层，内半透膜，含有脂肪酸盐和外肠层的中间层。
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公开(公告)号：US06773721B1
公开(公告)日：2004-08-10
申请号：US08442210
申请日：1995-05-16
IPC分类号： A61K924
CPC分类号： A61K9/0004 , A61K9/1635 , A61K9/4808 , A61K9/4816 , A61K9/4891
摘要： An osmotic caplet is disclosed comprising an osmotic caplet exit for delivering a preselected dose of drug to a patient in need of therapy.
摘要翻译： 公开了渗透性囊片，其包括用于将预选剂量的药物递送至需要治疗的患者的渗透性囊片出口。
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公开(公告)号：US5499979A
公开(公告)日：1996-03-19
申请号：US209033
申请日：1994-03-10
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of plurality of drugs in any desired delivery pattern or profile.
摘要翻译： 用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多种药物。
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