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公开(公告)号:US06476041B1
公开(公告)日:2002-11-05
申请号:US09696504
申请日:2000-10-25
申请人: Wayne Thompson , David A. Claremon , Peter M. Munson , Janusz Kulagowski , Willie Whitter , Ian Huscroft
发明人: Wayne Thompson , David A. Claremon , Peter M. Munson , Janusz Kulagowski , Willie Whitter , Ian Huscroft
IPC分类号: C07D47300
CPC分类号: C07D401/06 , C07D471/04 , C07D473/00
摘要: Novel piperidinyl compounds substituted in the 1- and 4-positions are effective as NMDA NR2B antagonists useful for relieving pain.
摘要翻译: 在1位和4位上取代的新型哌啶基化合物作为可用于缓解疼痛的NMDA NR2B拮抗剂是有效的。
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公开(公告)号:US06440976B2
公开(公告)日:2002-08-27
申请号:US09888694
申请日:2001-06-25
IPC分类号: C07D23942
CPC分类号: C07D239/42 , C07D471/04 , C07D487/04
摘要: Compounds described by the chemical structural formula or a pharmaceutically acceptable salt thereof, are useful in the treatment of pain, migraine, depression, anxiety, schizophrenia, Parkinson's disease, stroke, and in the treatment of neuropathies including postherpetic neuralgia, central pain from spinal cord injury, and phantom limb pain.
摘要翻译: 由化学结构式所描述的化合物或其药学上可接受的盐可用于治疗疼痛,偏头痛,抑郁症,焦虑症,精神分裂症,帕金森病,中风,以及治疗神经病,包括带状疱疹后神经痛,脊髓损伤中枢性疼痛 和幻肢痛。
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公开(公告)号:US06432976B1
公开(公告)日:2002-08-13
申请号:US09696503
申请日:2000-10-25
IPC分类号: A61K3146
CPC分类号: C07D451/02 , A61K31/46 , Y02P20/582
摘要: Novel 3-substituted 8-aza-bicyclo[3.2.1]octanes (commonly known as “tropanes”) substituted in the 8-position are effective as NMDA NR2B antagonists useful for relieving pain.
摘要翻译: 在8-位上取代的新的3-取代的8-氮杂 - 双环[3.2.1]辛烷(通常称为“丙酸”)作为可用于缓解疼痛的NMDA NR2B拮抗剂是有效的。
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公开(公告)号:US5439914A
公开(公告)日:1995-08-08
申请号:US198940
申请日:1994-02-18
IPC分类号: A61K31/445 , A61P9/06 , C07D221/20 , C07D491/10 , C07D491/107
CPC分类号: C07D221/20 , C07D491/10
摘要: Compounds of the general structural formula: ##STR1## or a pharmaceutically acceptable salt, hydrate or crystal form thereof, wherein;X is O or CH.sub.2R.sup.1 is H if R.sup.2 is not H or if R.sup.2 is H then R.sup.1 is ##STR2## R.sup.2 is --H if R.sup.1 is not H or if R.sup.1 is H then R.sup.2 is; ##STR3## and R.sup.3 is ##STR4## are Class HI antiarrhythmic agents.
摘要翻译: 通式结构式:化合物或其药学上可接受的盐,水合物或结晶形式,其中: X为O或CH2如果R2不为H,则R1为H,或者如果R2为H,则R1为
,如果R1不为H,则R2为-H,或者如果R1为H,则为R2。 而且图像是“IMAGE”,“IMA”是R3类抗心律失常药。 -
公开(公告)号:US5188830A
公开(公告)日:1993-02-23
申请号:US517915
申请日:1990-04-02
申请人: Joseph G. Atkinson , David A. Claremon , John J. Baldwin , Paul A. Friedman , David C. Remy , Andrew M. Stern
发明人: Joseph G. Atkinson , David A. Claremon , John J. Baldwin , Paul A. Friedman , David C. Remy , Andrew M. Stern
IPC分类号: A61K31/335 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/535 , A61K38/43
CPC分类号: A61K38/49 , A61K31/335 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/445 , A61K31/535 , C12Y304/21068
摘要: Certain Factor XIIIa inhibitor compounds have been discovered which have been found to be useful in the lysis of blood clots and thus adaptable for administration in thrombolytic therapy either alone or together with plasminogen activator.
摘要翻译: 已经发现已经发现某些因子XIIIa抑制剂化合物可用于溶血裂解血凝块,因此适用于单独或与纤溶酶原激活剂一起在溶栓治疗中施用。
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56.
公开(公告)号:US5152988A
公开(公告)日:1992-10-06
申请号:US657921
申请日:1991-02-20
IPC分类号: C07D233/84 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
CPC分类号: C07D401/12 , C07D233/84 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The use of imidazoles of the formula ##STR1## and imidazolium salts of the formula ##STR2## in thromobolytic therapy are described.
摘要翻译: 描述了在溶栓治疗中使用式IMAMA的咪唑和式“IMAGE”的咪唑鎓盐。
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57.
公开(公告)号:US5047416A
公开(公告)日:1991-09-10
申请号:US386645
申请日:1989-07-31
IPC分类号: A61K31/41 , A61K31/415 , A61K31/44 , A61P7/02 , C07D231/18 , C07D249/12 , C07D257/04 , C07D471/04
CPC分类号: C07D257/04 , C07D231/18 , C07D249/12 , C07D471/04
摘要: Azole compounds including azoles and azolium salts, and their use as transglutaminase inhibitors are disclosed.
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公开(公告)号:US4968713A
公开(公告)日:1990-11-06
申请号:US386642
申请日:1989-07-31
IPC分类号: C07D233/84 , A61K31/415 , A61P7/02 , A61P43/00
CPC分类号: A61K31/415
摘要: A method for inhibiting transglutaminase activity, especially Factor XIIIa activity with certain imidazole compounds is described. The imidazole compounds are those selected from(A) a imidazole having the formula ##STR1## or its acid addition salt, and ##STR2## wherein: R is hydrogen or lower alkyl;R.sup.1 is lower alkyl;R.sup.2 and R.sup.3 are independently hydrogen or lower alkyl;R.sup.4 is lower alkyl; andX is the negative radical of a pharmaceutically acceptable salt.Also described are compositions suitable for use in inhibiting transglutaminase activity.
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公开(公告)号:US4677101A
公开(公告)日:1987-06-30
申请号:US535502
申请日:1983-09-26
IPC分类号: A61K31/455 , A61K31/55 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P21/02 , C07D211/90 , C07D223/06 , C07D413/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07F7/18 , C07D491/06 , C07D487/12
CPC分类号: C07D413/04 , C07D211/90 , C07D223/06 , C07D487/14 , C07D491/04 , C07F7/1856 , Y10S514/929
摘要: Substituted dihydroazepines, their preparation, and the use thereof as calcium channel blockers are disclosed.
摘要翻译: 公开了取代的二氢吖庚因及其制备方法及其作为钙通道阻断剂的用途。
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公开(公告)号:US08927715B2
公开(公告)日:2015-01-06
申请号:US12310457
申请日:2007-08-24
申请人: David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Salvacion Cacatian , Wei He , Robert Simpson , Zhenrong Xu , Wei Zhao
发明人: David A. Claremon , Suresh B. Singh , Colin M. Tice , Yuanjie Ye , Salvacion Cacatian , Wei He , Robert Simpson , Zhenrong Xu , Wei Zhao
IPC分类号: A61K31/5377 , C07D471/10 , A61K31/438 , C07D221/20 , C07D401/10 , A61K31/496 , C07D413/10 , A61P3/00 , A61P9/12 , A61P9/00 , A61P25/22 , A61P25/28 , A61P25/24 , A61P15/08 , C07D211/26 , C07D413/06 , C07D211/22 , C07D491/107 , C07D211/16 , C07D211/34 , C07D401/08 , C07D401/06
CPC分类号: C07D221/20 , C07D211/16 , C07D211/22 , C07D211/26 , C07D211/34 , C07D401/06 , C07D401/08 , C07D413/06 , C07D471/10 , C07D491/107
摘要: This invention relates to novel compounds of the Formula (I*), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
摘要翻译: 本发明涉及式(I *)的新化合物,其药学上可接受的盐及其药物组合物,其可用于治疗与哺乳动物中11β-HSD1的调节或抑制相关的疾病的治疗。 本发明进一步涉及新化合物的药物组合物及其用于减少或控制细胞中皮质醇的产生或抑制细胞中可的松转化为皮质醇的方法。
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