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104 条记录 (耗时 0.036 秒)

    14094, a novel human trypsin family member and uses thereof
    55.
    发明申请
    14094, a novel human trypsin family member and uses thereof 审中-公开
    14094，一种新型人胰蛋白酶家族成员及其用途

    公开(公告)号：US20070009433A1

    公开(公告)日：2007-01-11

    申请号：US11403988

    申请日：2006-04-13

    申请人： Rachel Meyers ,  Kyle MacBeth

    发明人： Rachel Meyers ,  Kyle MacBeth

    IPC分类号： A61K51/00 ,  G01N33/574 ,  A61K39/395 ,  A61K38/17 ,  C40B30/06

    CPC分类号： A61K38/17 ,  A61K47/6871 ,  A61K51/1075 ,  A61K2039/505 ,  C07K16/40 ,  C12N9/6427 ,  G01N33/573 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2333/96433 ,  G01N2500/00

    摘要： The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in breast, ovarian, lung, and liver cancers compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14094 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14094 gene has been introduced or disrupted. The invention still further provides isolated 14094 proteins, fusion proteins, antigenic peptides and anti-14094 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent, and/or diagnose neoplastic conditions, are also provided.

    摘要翻译： 本发明提供编码新型胰蛋白酶家族成员的分离的核酸分子，命名为14094个核酸分子。 与来自这些组织的正常细胞相比，在乳腺癌，卵巢癌，肺癌和肝癌中检测到14094个mRNA的表达升高。 本发明还提供了反义核酸分子，含有14094个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及14094基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的14094蛋白，融合蛋白，抗原肽和抗-144094抗体。 还提供了利用本发明组合例如治疗，预防和/或诊断肿瘤病症的治疗和诊断方法。

    Compositions and methods for identifying and targeting cancer cells of alimentary canal origin
    56.
    发明申请
    Compositions and methods for identifying and targeting cancer cells of alimentary canal origin 审中-公开
    用于鉴定和靶向消化道起源的癌细胞的组合物和方法

    公开(公告)号：US20040033520A1

    公开(公告)日：2004-02-19

    申请号：US10428225

    申请日：2003-05-02

    发明人： Scott A. Waldman ,  Jason Park ,  Stephanie Schulz

    IPC分类号： C12Q001/68 ,  G01N033/574

    CPC分类号： A61K39/0011 ,  A61K9/127 ,  A61K31/7034 ,  A61K31/7048 ,  A61K47/6871 ,  A61K51/1075 ,  C07K16/3046 ,  C07K16/40 ,  C12N15/113 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57446 ,  G01N2333/988

    摘要： Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Compounds, compositions and methods of treating patients with metastatic colorectal cancer or stomach or esophageal cancer and for imaging metastatic colorectal cancer or stomach or esophageal tumors in vivo are disclosed. Compositions and methods for delivering active compounds such as drugs, gene therapeutics and antisense compounds to metastatic colorectal cancer or stomach or esophageal cells are disclosed. Vaccines compositions and methods of for treating and preventing metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed.

    摘要翻译： 公开了用于转移性结直肠癌或原发性和/或转移性胃或食管癌的筛选和诊断试剂，试剂盒和方法。 公开了治疗患有转移性结肠直肠癌或胃或食管癌的患者以及体内成像转移性结直肠癌或胃或食管肿瘤的化合物，组合物和方法。 公开了用于将活性化合物如药物，基因治疗剂和反义化合物递送至转移性结肠直肠癌或胃或食管细胞的组合物和方法。 公开了用于治疗和预防转移性结肠直肠癌或原发性和/或转移性胃或食管癌的疫苗组合物和方法。

    HUMANISED ANTI KALLIKREIN-2 ANTIBODY
    59.
    发明申请
    HUMANISED ANTI KALLIKREIN-2 ANTIBODY 审中-公开
    人类抗原KALLIKREIN-2抗体

    公开(公告)号：US20160369009A1

    公开(公告)日：2016-12-22

    申请号：US15036170

    申请日：2014-11-19

    申请人： FREDAX AB

    发明人： Par Oskar Vilhelmsson Timmermand ,  Amanda Thuy Tran ,  Sven-Erik Strand ,  Urpo Juhani Lamminmaki

    IPC分类号： C07K16/40 ,  A61K51/10

    CPC分类号： C07K16/40 ,  A61K51/1045 ,  A61K51/1075 ,  A61K51/1096 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： The present invention provides antibody polypeptides with binding specificity for human kallikrein-2 (hK2), wherein the antibody polypeptide comprises (a) a heavy chain variable region comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2 and SEQ ID NO: 3 and/or (b) a light chain variable region comprising the amino acid sequences of SEQ ID NO: 4 and SEQ ID NO: 5 and SEQ ID NO: 6, and wherein the heavy chain variable region and light chain variable region comprise framework amino acid sequences from one or more human antibodies. The invention further provides use of said antibody polypeptides in the diagnosis and treatment of prostate cancer.

    摘要翻译： 本发明提供对人激肽释放酶-2（hK2）具有结合特异性的抗体多肽，其中所述抗体多肽包含（a）包含SEQ ID NO：1和SEQ ID NO：2和SEQ ID NO：2的氨基酸序列的重链可变区 （SEQ ID NO：3）和/或（b）包含SEQ ID NO：4和SEQ ID NO：5和SEQ ID NO：6的氨基酸序列的轻链可变区，其中重链可变区和轻链可变区 区域包含来自一个或多个人抗体的框架氨基酸序列。 本发明进一步提供所述抗体多肽在前列腺癌的诊断和治疗中的用途。