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公开(公告)号：US20050255575A1
公开(公告)日：2005-11-17
申请号：US11115502
申请日：2005-04-27
Applicant: Dhandapani Venkataraman , Craig Bates , Pranorm Saejueng
Inventor： Dhandapani Venkataraman , Craig Bates , Pranorm Saejueng
IPC: C07B37/04 , C07C2/86 , C07C67/343 , C07C205/56 , C07C319/20 , C07C323/62 , C07D213/55 , C07D333/16 , C07D333/24 , C12N9/00
CPC classification number: C07C205/56 , B01J31/1805 , B01J31/1815 , B01J31/183 , B01J31/2217 , B01J2231/4266 , B01J2531/16 , C07B37/04 , C07C2/861 , C07C67/343 , C07C201/12 , C07C253/30 , C07C319/20 , C07C2527/167 , C07C2531/24 , C07C2602/10 , C07D213/55 , C07D333/16 , C07D333/24 , C12N9/00 , C07C11/28 , C07C69/65 , C07C69/606 , C07C69/738 , C07C69/76 , C07C69/618 , C07C69/734 , C07C323/62 , C07C255/57
Abstract: A copper(I) bi-dentate ligand complex-catalyzed procedure for synthesis of 1,3-enynes. The methods and/or systems of this invention afford a variety of enynes, tolerate a variety of sensitive functional groups, and can be employed without resort to expensive palladium reagents.
Abstract translation: 铜（I）双齿配体配合物催化合成1,3-烯炔的方法。 本发明的方法和/或系统提供各种烯炔，可耐受各种敏感的官能团，并且可以在不使用昂贵的钯试剂的情况下使用。
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公开(公告)号：US20050038289A1
公开(公告)日：2005-02-17
申请号：US10484457
申请日：2002-07-23
Applicant: Richard Gordon , Tessa Early , Andrew Holmes
Inventor： Richard Gordon , Tessa Early , Andrew Holmes
IPC: B01J3/00 , B01J23/44 , B01J31/04 , B01J31/06 , B01J31/16 , B01J31/18 , B01J31/24 , C07B37/04 , C07C1/32 , C07C41/30 , C07C51/09 , C07C67/343 , C07C205/06 , C07C205/56 , C07C51/10 , C07C51/14
CPC classification number: C07C41/30 , B01J3/008 , B01J23/44 , B01J31/06 , B01J31/1658 , B01J31/1805 , B01J31/2404 , B01J2219/00094 , B01J2231/4205 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2531/824 , B01J2531/922 , C07B37/04 , C07B2200/11 , C07C1/321 , C07C51/09 , C07C67/343 , C07C201/12 , C07C2521/18 , C07C2523/44 , C07C15/00 , C07C59/84 , C07C63/331 , C07C57/44 , C07C69/732 , C07C69/65 , C07C69/734 , C07C69/738 , C07C69/618 , C07C205/06 , C07C205/56 , C07C43/205
Abstract: A palladium-catalysed carbon-carbon bond forming reaction in compressed carbon dioxide is provided wherein at least one of the reagents used in said reaction is bounded to a solid polymer support. In a second aspect, a palladium-catalysed carbon-carbon bond forming reaction in compressed carbon dioxide is provided wherein said reaction is performed in the presence of a tetra-alkylammonium acetate. In a third aspect, a palladium-catalysed carbon-carbon bond forming reaction in compressed carbon dioxide is provided wherein said palladium catalyst does not have any fluorinated phosphine ligands but does have at least one phosphine ligand that has at least one substituent that is selected from tert-alkyl groups, cycloalkyl groups and optionally substituted phenyl groups or 1′-diphenylphosphino-biphenyl. In a fourth aspect, there is provided a palladium-catalysed Suzuki or Heck reaction in compressed carbon dioxide wherein both of the substrates being combined in said reactions are boronic acids.
Abstract translation: 提供了在压缩二氧化碳中形成钯催化的碳 - 碳键反应，其中所述反应中使用的至少一种试剂与固体聚合物载体结合。 在第二方面，提供了在压缩二氧化碳中形成钯催化的碳 - 碳键反应，其中所述反应在四烷基乙酸铵存在下进行。 在第三方面，提供了在压缩二氧化碳中形成钯催化的碳 - 碳键反应，其中所述钯催化剂不具有任何氟化膦配体，但是具有至少一个具有至少一个选自以下的取代基的膦配体： 叔烷基，环烷基和任选取代的苯基或1'-二苯基膦基 - 联苯。 在第四方面，提供了在压缩二氧化碳中的钯催化的Suzuki或Heck反应，其中在所述反应中组合的两种底物都是硼酸。
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53.发明申请
公开(公告)号：US20040106151A1
公开(公告)日：2004-06-03
申请号：US10466124
申请日：2003-07-10
Inventor： Christopher Holmes , Yijun Pan
IPC: G01N033/53 , B01J031/00
CPC classification number: C40B50/14 , B01J19/0046 , B01J20/289 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3257 , B01J31/10 , B01J31/1658 , B01J31/2208 , B01J31/2409 , B01J2219/00283 , B01J2219/00454 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/0072 , B01J2219/00738 , B01J2231/4211 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2531/824 , C07B2200/11 , C07C309/10 , C07C309/24 , C07C309/82 , C07C309/84 , C07F7/0834 , C40B60/14 , C40B80/00 , C40B99/00
Abstract: Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula (I) wherein L is a linking group component; X is F, CL, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic sync) thesis are also provided.
Abstract translation: 提供活化载体，支持活化剂，强酸性载体和甲硅烷基化载体; 具有式（I）的活化载体，其中L是连接基团组分; X是F，CL，OH和三取代的甲硅烷氧基; 阴影圆表示固体或半固体支持物。 还提供了在固相有机同步中使用活化载体的方法。
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公开(公告)号：US20040068131A1
公开(公告)日：2004-04-08
申请号：US10333860
申请日：2003-07-25
Inventor： Matthias Beller , Andreas Ehrentraut , Wilhelm Hubert Ehrentraut , Theresia Elisabeth Ehrentraut , Christa Fuhrmann , Alexander Zapf
IPC: C07F009/02
CPC classification number: C07F15/065 , B01J31/24 , B01J31/2447 , B01J2231/4211 , B01J2231/4261 , B01J2231/4266 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/845 , B01J2531/847 , C07B37/04 , C07C1/26 , C07C17/263 , C07C45/68 , C07C209/10 , C07C213/02 , C07C253/30 , C07C2531/22 , C07C2603/74 , C07D295/023 , C07F9/5018 , C07F9/5027 , C07F15/0033 , C07F15/004 , C07F15/0046 , C07F15/0053 , C07F15/006 , C07F15/0066 , C07F15/0086 , C07F15/0093 , C07F15/04 , C07F15/045 , C07F15/06 , C07C49/84 , C07C49/233 , C07C49/813 , C07C49/657 , C07C49/784 , C07C49/213 , C07C49/67 , C07C211/48 , C07C211/55 , C07C211/56 , C07C217/84 , C07C255/50
Abstract: The invention relates to novel phosphane ligands of formula (Ia) and (Ib): (adamantyl)nP(alkyl)m(1a); (adamantyl)o(Alkyl)qP (alkylennull)P(adamantyl)r(alkyl)s (1b), wherein adamantyl represents an adamantyl radical (IIa, IIb) bonded to the phosphorous atom in position 1 or 2. The invention also relates to the production and use of the above-mentioned ligands in the presence of transitional metal compounds of the 8th. Subgroup of PSE for catalytic reactions, particularly for the refining of halogen aromatics for producing aryl olefins, dienes, diarylene, benzoic acid and acrylic acid derivatives, aryl alkanes and also amines.
Abstract translation: 本发明涉及式（Ia）和（Ib）的新型膦烷配体：（金刚烷基）nP（烷基）m（1a）; （金刚烷基）o（烷基）qP（亚烷基）P（金刚烷基）r（烷基）s（1b），其中金刚烷基表示键合到位置1或2上的磷原子的金刚烷基（IIa，IIb） 涉及在第八届过渡金属化合物存在下上述配体的生产和使用。 用于催化反应的PSE亚组，特别是用于制备芳族烯烃，二烯，二亚芳基，苯甲酸和丙烯酸衍生物，芳基烷烃和胺的卤素芳族化合物的精制。
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公开(公告)号：US20030229240A1
公开(公告)日：2003-12-11
申请号：US10417989
申请日：2003-04-17
Inventor： Florian Rampf , Hans-Christian Militzer
IPC: C07F009/02 , C07C319/02 , C07C269/02
CPC classification number: C07B37/04 , B01J31/24 , B01J31/2404 , B01J31/2409 , B01J31/2414 , B01J31/2447 , B01J2231/4211 , B01J2231/4233 , B01J2231/4238 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2531/0205 , C07F9/5068 , C07F9/5442
Abstract: The invention relates to a process for synthesizing tertiary phosphines by reacting halophosphines with organomagnesium compounds in the presence of copper compounds and optionally of salts.
Abstract translation: 本发明涉及在铜化合物和任选的盐存在下使卤代膦与有机镁化合物反应合成叔膦的方法。
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56.发明申请Perfluoro sulfonyl halides and related species as polymer support modifiers 审中-公开全氟磺酰卤和相关物质作为聚合物载体改性剂
公开(公告)号：US20030124612A1
公开(公告)日：2003-07-03
申请号：US10044784
申请日：2002-01-11
Inventor： Christopher Holmes , Yijun Pan
IPC: G01N033/53 , C08F291/00 , C08F008/36
CPC classification number: C40B50/14 , B01J19/0046 , B01J20/289 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J20/3257 , B01J31/10 , B01J31/1658 , B01J31/2208 , B01J31/2409 , B01J2219/00283 , B01J2219/00454 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/0072 , B01J2219/00738 , B01J2231/4211 , B01J2231/4255 , B01J2231/4261 , B01J2231/4266 , B01J2531/824 , C07B2200/11 , C07C309/10 , C07C309/24 , C07C309/82 , C07C309/84 , C07F7/0834 , C40B60/14 , C40B80/00 , C40B99/00
Abstract: Activated Supports, support-bound activators, strongly acidic supports, and silylating supports are provided; the activated support having the formula: 1 wherein L is a linking group component; X is F, Cl, OH, and trisubstituted silyloxy; and the shaded circle represents a solid or semi-solid support. Methods of using the activated supports in solid phase organic synthesis are also provided.
Abstract translation: 提供活化载体，支持活化剂，强酸性载体和甲硅烷基化载体; 所述活化载体具有下式：其中L是连接基团组分; X是F，Cl，OH和三取代的甲硅烷氧基; 阴影圆表示固体或半固体支持物。 还提供了在固相有机合成中使用活化载体的方法。
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公开(公告)号：US20170341069A1
公开(公告)日：2017-11-30
申请号：US15624400
申请日：2017-06-15
Applicant: The Regents of The University of California
Inventor： Bruce H. Lipshutz , Sachin Handa
IPC: B01J31/24 , C07D409/04 , B01J23/89 , B01J31/02 , B01J31/06 , B01J31/22 , B01J35/00 , B01J35/12 , B01J37/16 , C07B37/04 , C07C41/30 , C07D405/14 , C07D405/04 , C07D403/04 , C07D401/04 , C07D333/60 , C07D317/46 , C07D317/22 , C07D241/18 , C07D239/54 , C07D239/26 , C07D215/06 , C07D213/64 , C07D213/30 , C07D211/70 , C07C319/20 , C07C269/06 , C07C211/45 , C07C209/68 , C07C209/32 , C07C205/12 , C07C201/12 , C07C45/68 , C07D471/04 , C07C2603/24
CPC classification number: B01J31/2404 , B01J23/8906 , B01J31/0202 , B01J31/0209 , B01J31/068 , B01J31/22 , B01J35/0013 , B01J35/10 , B01J35/12 , B01J37/16 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2231/64 , B01J2531/004 , B01J2531/007 , B01J2531/824 , B01J2531/842 , B01J2531/96 , B01J2531/985 , C07B37/04 , C07C37/18 , C07C41/30 , C07C45/68 , C07C201/12 , C07C205/12 , C07C209/325 , C07C209/68 , C07C211/45 , C07C269/06 , C07C269/08 , C07C319/20 , C07C2603/24 , C07D211/70 , C07D213/30 , C07D213/64 , C07D215/06 , C07D239/26 , C07D239/54 , C07D241/18 , C07D317/22 , C07D317/46 , C07D333/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D471/04 , C07F9/12 , C07C271/28 , C07C321/28 , C07C43/215 , C07C43/205 , C07C43/2055 , C07C47/546 , C07C47/575 , C07C39/21
Abstract: In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Ir, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.
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58.发明授权Palladium(II) complex for catalyzing sonogashira coupling reactions and a method thereof 有权用于催化Sonogashira偶合反应的钯（II）络合物及其方法
公开(公告)号：US09546191B1
公开(公告)日：2017-01-17
申请号：US15081308
申请日：2016-03-25
Inventor： Bassam M. El Ali , Mansur Bala Ibrahim , Rami K. Suleiman
IPC: C07F15/00 , C07C45/68 , C07C17/26 , C07C253/30 , C07F7/08 , C07F7/18 , C07C29/32 , C07C209/68 , C07B37/00 , B01J31/18 , C07C2/86
CPC classification number: C07F15/0066 , B01J31/182 , B01J2231/4266 , B01J2531/824 , C07B37/04 , C07C2/861 , C07C17/269 , C07C29/32 , C07C45/68 , C07C201/12 , C07C209/68 , C07C253/30 , C07C2531/22 , C07D263/12 , C07F7/083 , C07F7/1892 , C07C22/08 , C07C22/04 , C07C49/796 , C07C33/30 , C07C205/06 , C07C255/50 , C07C255/56 , C07C211/45 , C07C211/49 , C07C15/54
Abstract: A palladium(II) complex which catalyzes the Sonogashira coupling reaction efficiently under aerobic condition and a method of employing the palladium(II) complex to synthesize internal alkynes. The palladium(II) complex is an effective catalyst for the coupling reactions of aryl iodo and diiodo compounds with unactivated alkyl alkynes and terminal dialkynes to produce various novel symmetrical dialkynes and disubstituted internal alkynes in excellent yields.
Abstract translation: 在需氧条件下有效催化Sonogashira偶联反应的钯（II）络合物和使用钯（II）络合物合成内部炔烃的方法。 钯（II）络合物是芳基碘和二碘化合物与未活化的烷基炔烃和末端二炔烃的偶联反应的有效催化剂，以产生各种新型对称二炔烃和二取代的内炔烃，产率高。
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公开(公告)号：US20160340332A1
公开(公告)日：2016-11-24
申请号：US15167975
申请日：2016-05-27
Applicant: MyCell Technologies, LLC
Inventor： Volker Berl
IPC: C07D311/72 , C07D223/04 , C07F7/18 , C07C67/343 , C07C41/30 , C07D213/74 , C07C209/10 , C07C17/26 , C07C209/18 , C07C209/16 , C07C227/18 , C07C231/12 , C07F7/08 , C07C273/18 , C07C253/30 , C07F5/02 , C07B37/00 , C07C2/86 , C07C1/32 , B01J31/22 , B01J31/24 , B01J31/18 , B01J31/02 , C07D211/02
CPC classification number: C07D311/72 , B01J31/0209 , B01J31/1805 , B01J31/22 , B01J31/2208 , B01J31/2278 , B01J31/24 , B01J31/2414 , B01J31/28 , B01J2231/4216 , B01J2231/4261 , B01J2231/4266 , B01J2231/44 , B01J2231/543 , B01J2531/824 , C07C1/321 , C07C2/861 , C07C17/26 , C07C41/30 , C07C67/343 , C07C209/08 , C07C209/10 , C07C209/16 , C07C209/18 , C07C221/00 , C07C227/18 , C07C231/12 , C07C253/30 , C07C273/1854 , C07C2531/24 , C07C2601/16 , C07C2603/74 , C07D211/02 , C07D213/74 , C07D223/04 , C07D249/06 , C07F7/1892 , C07C69/618 , C07C69/734 , C07C43/215 , C07C43/225 , C07C43/205 , C07C15/12 , C07C13/21
Abstract: In one embodiment, the present application discloses mixtures comprising (a) water in an amount of at least 1% wt/wt of the mixture; (b) a transition metal catalyst; and (c) one or more solubilizing agents; and methods for using such mixtures for performing transition metal mediated bond formation reactions.
Abstract translation: 在一个实施方案中，本申请公开了包含（a）至少1重量％/重量比混合物的水的混合物; （b）过渡金属催化剂; 和（c）一种或多种增溶剂; 以及使用这种混合物进行过渡金属介导的键形成反应的方法。
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60.发明申请NANO-TO-NANO FE/PPM Pd CATALYSIS OF CROSS-COUPLING REACTIONS IN WATER 审中-公开NANO-TO-NANO FE / PPM Pd在水中的交联反应的催化
公开(公告)号：US20160339418A1
公开(公告)日：2016-11-24
申请号：US15158238
申请日：2016-05-18
Applicant: Bruce H. Lipshutz , Sachin Handa
Inventor： Bruce H. Lipshutz , Sachin Handa
IPC: B01J31/24 , C07C45/68 , C07F9/12 , C07D317/46 , C07C201/12 , C07D317/22 , C07D213/64 , C07D239/26 , C07D213/30 , C07D241/18 , C07D215/06 , C07D471/04 , C07D333/60 , C07D239/54 , C07D211/70 , C07D409/04 , C07D403/04 , C07D401/04 , C07D405/14 , C07D405/04 , B01J31/22 , B01J35/00 , B01J35/12 , C07C41/30
CPC classification number: B01J31/2404 , B01J23/8906 , B01J31/0202 , B01J31/0209 , B01J31/068 , B01J31/22 , B01J35/0013 , B01J35/10 , B01J35/12 , B01J37/16 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2231/64 , B01J2531/004 , B01J2531/007 , B01J2531/824 , B01J2531/842 , B01J2531/96 , B01J2531/985 , C07B37/04 , C07C37/18 , C07C41/30 , C07C45/68 , C07C201/12 , C07C205/12 , C07C209/325 , C07C209/68 , C07C211/45 , C07C269/06 , C07C269/08 , C07C319/20 , C07C2603/24 , C07D211/70 , C07D213/30 , C07D213/64 , C07D215/06 , C07D239/26 , C07D239/54 , C07D241/18 , C07D317/22 , C07D317/46 , C07D333/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D471/04 , C07F9/12 , C07C271/28 , C07C321/28 , C07C43/215 , C07C43/205 , C07C43/2055 , C07C47/546 , C07C47/575 , C07C39/21
Abstract: In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Jr, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.
Abstract translation: 在一个实施方案中，本申请公开了一种催化剂组合物，其包含：a）反应溶剂或反应介质; b）有机金属纳米颗粒，其包含：i）通过在有机溶剂中还原铁盐制备的纳米颗粒（NP）催化剂，其中所述催化剂包含至少一种选自Pd，Pt，Au，Ni ，Co，Cu，Mn，Rh，Jr，Ru和Os或其混合物; c）配体; 和d）表面活性剂; 其中所述金属或其混合物相对于所述铁盐以小于或等于50,000ppm的量存在。
