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166 条记录 (耗时 0.02 秒)

    Novel uses of dl-THP
    51.
    发明申请
    Novel uses of dl-THP 有权
    dl-THP的新用途

    公开(公告)号：US20020143067A1

    公开(公告)日：2002-10-03

    申请号：US09819367

    申请日：2001-03-28

    发明人： Hong Xue ,  Sek Lun Law

    IPC分类号： A61K031/13

    CPC分类号： A61K31/4745

    摘要： The present invention is concerned with new, previously unsuggested, therapeutic uses of dl-THP (dl-tetrahydropalmatine).

    摘要翻译： 本发明涉及dl-THP（dl-tetrahydropalmatine）的新的，先前未提及的治疗用途。

    Anti-hypertensive composition and methods of treatment
    52.
    发明申请
    Anti-hypertensive composition and methods of treatment 失效
    抗高血压组合物及治疗方法

    公开(公告)号：US20020132815A1

    公开(公告)日：2002-09-19

    申请号：US10091395

    申请日：2002-03-07

    发明人： Raymond J. Bergeron JR.

    IPC分类号： A61K031/506 ,  A61K031/13

    CPC分类号： A61K31/136 ,  A61K31/131

    摘要： Pharmaceutical compositions for the treatment of hypertension comprising an effective anti-hypertensive amount of at least one compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound having one of the formulae (I), (II), (III) or (IV), and methods for the treatment of hypertension or effecting anti-hypertensive action which comprises administering to a patient requiring anti-hypertensive therapy or effect at least one of the above-described compounds.

    摘要翻译： 用于治疗高血压的药物组合物，其包含与药学上可接受的，基本上无毒的载体或赋形剂结合的有效抗高血压量的至少一种化合物，所述化合物具有式（I），（II），（II）， III）或（IV），以及治疗高血压或进行抗高血压作用的方法，其包括对需要抗高血压治疗或影响至少一种上述化合物的患者施用。

    AMPHIPATIC LIPID DISPERSION
    55.
    发明申请
    AMPHIPATIC LIPID DISPERSION 有权
    大鼠脂质分散体

    公开(公告)号：US20020058052A1

    公开(公告)日：2002-05-16

    申请号：US09468777

    申请日：1999-12-21

    发明人： KEIKO HASEBE ,  JURI SATA ,  YASUHIRO DOI ,  YOSHINORI TAMURA ,  MASAKI INOUE ,  HIROSHI SONOHARA

    IPC分类号： A61K007/06 ,  A61K007/075 ,  A61K007/08 ,  A61K006/00 ,  A61K007/00 ,  A61K031/16 ,  A61K031/13 ,  A61K033/18

    CPC分类号： A61K8/39 ,  A61K8/442 ,  A61K8/4993 ,  A61K8/604 ,  A61K8/68 ,  A61Q5/02 ,  A61Q15/00 ,  A61Q19/10 ,  Y10S514/88

    摘要： Described in the present invention are a dispersion which comprises, as a dispersoid, (a) 5 to 40 wt. % of an amphipatic lipid containing, in the molecule thereof, at least one hydroxy and amide group, and (b) 2 to 55 wt. % of a surfactant in an aqueous medium; a washing-away type cosmetic composition comprising the dispersion; and a washing-away type cosmetic composition comprising (A) 0.01 to 10 wt. % of an amphipatic lipid which contains, in the molecule thereof, at least one hydroxy and amide group and having a melting point not less than 30null C. and (B) 5 to 95 wt. % of a surfactant. The dispersion according to the present invention is useful as a component of a washing-away type cosmetic composition having both an emulsion-like or pearl-lustrous appearance and low skin irritation. The washing-away type cosmetic composition according to the present invention has an emulsion-like or pearl-lustrous appearance and is mild to the skin owing to reduced adsorption, to the skin, of the surfactant contained in the composition.

    摘要翻译： 在本发明中描述的是一种分散体，其包含作为分散质的（a）5至40重量％ 在其分子中含有至少一个羟基和酰胺基团的两性脂质的百分比，和（b）2-55重量％ ％表面活性剂在水性介质中; 一种洗涤型化妆品组合物，其包含该分散体; 和洗涤型化妆品组合物，其包含（A）0.01〜10重量％ 在其分子中含有至少一个羟基和酰胺基并且具有不低于30℃的熔点和（B）5-95重量％的两性脂质的百分比。 ％的表面活性剂。 根据本发明的分散体可用作洗涤型化妆品组合物的组分，其具有乳状液或珍珠岩外观和低皮肤刺激性。 根据本发明的洗衣型化妆品组合物具有乳状或珍珠色的外观，并且由于组合物中包含的表面活性剂对皮肤的吸附减少，对皮肤温和。

    Combination therapy of respiratory diseases using antibodies
    57.
    发明申请
    Combination therapy of respiratory diseases using antibodies 审中-公开
    使用抗体联合治疗呼吸系统疾病

    公开(公告)号：US20020004046A1

    公开(公告)日：2002-01-10

    申请号：US09848390

    申请日：2001-05-03

    发明人： Leslie S. Johnson

    IPC分类号： A61K039/42 ,  A61K031/7052 ,  A61K031/13

    CPC分类号： C07K16/248 ,  A61K39/42 ,  A61K2039/505 ,  C07K16/1027 ,  A61K2300/00

    摘要： Therapeutically effective anti-microbial compositions, useful especially against respiratory diseases caused or mediated by viruses, bacteria, and other respiratory parasites are disclosed, wherein said compositions comprise at least one neutralizing antibody, including high affinity antibodies, and an additional anti-infectious agent, such as an antiviral agent, for example, ribavirin, amantadine, rimantadine, or a neuraminidase-inhibitor. or anti-bacterial agents, including other antibodies. Also disclosed are methods of using such compositions to treat and/or prevent respiratory and related diseases.

    摘要翻译： 公开了治疗上有效的抗微生物组合物，特别是针对由病毒，细菌和其他呼吸寄生虫引起或介导的呼吸系统疾病，其中所述组合物包含至少一种中和抗体，包括高亲和力抗体和另外的抗感染剂， 例如抗病毒剂，例如利巴韦林，金刚烷胺，金刚乙胺或神经氨酸酶抑制剂。 或抗菌剂，包括其他抗体。 还公开了使用这种组合物治疗和/或预防呼吸系统和相关疾病的方法。

    Diagnosis and treatment of herpes infections
    58.
    发明申请
    Diagnosis and treatment of herpes infections 审中-公开
    疱疹感染的诊断和治疗

    公开(公告)号：US20010049113A1

    公开(公告)日：2001-12-06

    申请号：US09681740

    申请日：2001-05-30

    发明人： Patrick W.K. Lee ,  Faris Farassati ,  An-Dao Yang

    IPC分类号： A61K031/35 ,  A61K031/235 ,  A61K031/24 ,  A61K031/195 ,  A61K031/13 ,  G01N033/567 ,  G01N033/53 ,  C12Q001/02

    CPC分类号： A61K31/195 ,  A61K31/13 ,  A61K31/235 ,  A61K31/24 ,  A61K31/35 ,  G01N33/56994

    摘要： Methods and compositions for treating or preventing virus infections by interfering with the activity or function of Ras, the Ras pathway, the ERK pathway, MEK1/2, PKR or eIF-2 null, includes the use of agents which inhibit Ras or otherwise modulate anti-PKR activity. Also, a method of diagnosing such virus infections includes the use of cell lines that have an activated Ras pathway, including cell lines which have been transformed with a gene that activates the Ras pathway. The virus infections may be herpes virus infections and HSV-1 or HSV-2 infections in particular.

    摘要翻译： 通过干扰Ras，Ras途径，ERK途径，MEK1 / 2，PKR或eIF-2α的活性或功能来治疗或预防病毒感染的方法和组合物包括使用抑制Ras或以其他方式调节抗体的药物 -PKR活动。 此外，诊断这种病毒感染的方法包括使用具有活化的Ras途径的细胞系，包括已经用激活Ras途径的基因转化的细胞系。 病毒感染可能是疱疹病毒感染，特别是HSV-1或HSV-2感染。

    Amine derivative with potassium channel regulatory function, its preparation and use
    59.
    发明申请
    Amine derivative with potassium channel regulatory function, its preparation and use 有权
    胺衍生物具有钾通道调节功能，其制备和应用

    公开(公告)号：US20040266822A1

    公开(公告)日：2004-12-30

    申请号：US10466712

    申请日：2004-08-12

    发明人： Hai Wang ,  Liuhong Yun ,  Huasong Feng ,  Fulin Li ,  Xingehun Tang ,  Huamei He ,  Rifang Yang ,  Wenyu Cui ,  Qixiu Gao ,  Gang Hu ,  Rusheng Zhao ,  Wei Liu ,  Chaoliang Long ,  Lin Wang ,  Xinqiang Lu ,  Lijun Liu ,  Yuan Yan

    IPC分类号： C07D211/20 ,  A61K031/445 ,  A01N043/36 ,  C07D207/04 ,  A61K031/13

    CPC分类号： C07D213/82 ,  A61K31/13 ,  C07C211/08

    摘要： The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression. 1

    摘要翻译： 本发明提供由式I表示的胺衍生物，其异构体，消旋体或光学异构体，其药用盐，其酰胺或酯，含有所述化合物的药物组合物及其制备方法。 本发明还涉及上述化合物在制备用于预防或治疗心血管疾病，糖尿病，支气管和尿平滑肌痉挛以及缺血性和缺氧性神经损伤的药物中的用途。 上述化合物可用于治疗高血压，心绞痛，心肌梗塞，充血性心力衰竭，心律失常，糖尿病，痉挛性支气管疾病，痉挛性膀胱或输尿管疾病以及抑郁症。