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公开(公告)号：US11427560B2
公开(公告)日：2022-08-30
申请号：US16998963
申请日：2020-08-20
Applicant: The Scripps Research Institute , Universität Bremen
Inventor： Hank Michael James Petrassi , Murali Mohan Reddy Peram Surakattula , Kathrin Maedler , Amin Ardestani , Jason T. Roland , Tyler D. Baguley , Matthew S. Tremblay , Weijun Shen , Peter G. Schultz , Arnab K. Chatterjee
IPC: C07D401/12 , A61K31/47 , C12N9/12 , A61K31/517 , A61K31/4709 , C07D215/44 , C07D215/46 , C07D413/12 , C07D471/04 , C07D491/052 , C07D491/056
Abstract: Disclosed herein are compounds, compositions, and methods of their use for the treatment of diabetes.
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公开(公告)号：US20210147385A1
公开(公告)日：2021-05-20
申请号：US17072844
申请日：2020-10-16
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ATENGEN, INC.
Inventor： HUI SUN , Pu Sun , Guo Cheng , Adrian Chichuen Au , Ming Zhong
IPC: C07D401/14 , A61P35/00 , C07D215/46 , C07D215/42 , C07D401/04 , C07D215/44 , C07D491/113 , C07D401/12 , C07H15/26 , C07D487/08 , C07D405/14 , C07D498/04 , C07D405/12 , C07D417/12 , C07D409/12
Abstract: The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessles. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.
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53.发明授权
公开(公告)号：US10934284B2
公开(公告)日：2021-03-02
申请号：US16285460
申请日：2019-02-26
Applicant: Wellstat Therapeutics Corporation
Inventor： David M. Simpson , Dennis Bryan Zerby , Ming Lu , Reid W. Von Borstel , Rui Li , Julian Reading , Stephen Wolpe
IPC: C07D471/04 , A61K31/337 , A61K31/4164 , A61K31/437 , A61K31/44 , A61K31/4425 , A61K31/4709 , A61K31/4745 , A61K31/475 , A61K31/505 , A61K31/517 , A61K31/555 , A61K31/704 , A61K31/40 , A61K31/4184 , A61K31/472 , A61K31/4965 , A61K31/498 , C07D215/42 , C07D215/44 , A61K31/4706 , A61P35/00 , A61P33/02 , A01N43/42 , A01N43/50 , A01N43/54 , A01N43/60 , A01N43/90 , C07D209/12 , C07D213/73 , C07D213/74 , C07D215/38 , C07D215/40 , C07D215/46 , C07D233/60 , C07D235/08 , C07D239/42 , C07D239/94 , C07D241/20 , C07D241/44 , C07D401/12
Abstract: Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
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公开(公告)号：US20200079739A1
公开(公告)日：2020-03-12
申请号：US16468657
申请日：2017-12-12
Applicant: St. Jude Children's Research Hospital
Inventor： R. Kip Guy , P. Jake Slavish , William Robert Shadrick , Brandon M. Young , Vincent A. Boyd , Nagakumar Bharatham , Jeanine E. Price , Anang Shelat
IPC: C07D215/42 , C07D215/44 , C07D405/12 , C07D401/12 , C07D413/12 , C07D401/10 , C07D405/10 , C07D409/10 , C07D215/46
Abstract: In one aspect, compounds and compositions that modulate a bromodomain and methods of making and using same are disclosed. The disclosed compounds and compositions can be useful for disorders associated with inhibition of a bromodomain such as, for example, cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20190389803A1
公开(公告)日：2019-12-26
申请号：US16479081
申请日：2018-01-16
Applicant: Kagoshima University , Nobelpharma Co., Ltd.
Inventor： Masanori BABA , Masaaki TOYAMA , Norikazu SAKAKIBARA
IPC: C07D215/44 , C07D417/12 , C07D413/12 , C07D401/12 , A61P31/12
Abstract: The present invention pertains to an antiviral drug for severe fever with thrombocytopenia syndrome, which contains a compound represented by formula (I) or a salt thereof, or a solvate of the compound or salt (In the formula, R1 and R2 are the same or different from each other, and each represents a substituted or unsubstituted C1-10 alkyl group, R1 and R2 may form a substituted or unsubstituted 5- or 6-member ring in conjunction with an adjacent nitrogen atom, and X represent a halogen atom.)
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公开(公告)号：US10420845B2
公开(公告)日：2019-09-24
申请号：US15737247
申请日：2016-06-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Doron Shabat , Ronit Satchi-Fainaro , Samer Gnaim , Anna Scomparin
IPC: C07D491/22 , A61K47/54 , A61K31/436 , A61K31/4188 , A61K31/497 , A61K31/519 , C07D487/04 , C07D215/44 , A61P35/00 , A61K31/4184 , A61K31/4745 , A61K31/496 , A61K31/513
Abstract: The present disclosure provides heteroarene-based drug derivatives having a “clickable” ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions comprising them.
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公开(公告)号：US10220030B2
公开(公告)日：2019-03-05
申请号：US15811712
申请日：2017-11-14
Inventor： Michael Jonathan Bury , Linda N. Casillas , Adam Kenneth Charnley , Pamela A. Haile , Robert W. Marquis, Jr. , John F. Mehlmann , Joseph J. Romano , Robert R. Singhaus, Jr. , Gren Z. Wang
IPC: A61K31/4709 , C07D401/12 , C07D405/14 , C07D417/12 , C07D215/44 , C07D405/12 , C07D417/14 , C07D471/04 , A61K31/4706
Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3 and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US10125117B2
公开(公告)日：2018-11-13
申请号：US14800194
申请日：2015-07-15
Inventor： Milan Stojanovic , Francine Katz , Donald W. Landry
IPC: C07D401/12 , C07D233/60 , C07D215/44
Abstract: Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
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公开(公告)号：US20180222883A1
公开(公告)日：2018-08-09
申请号：US15887214
申请日：2016-08-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Hai-Yun XIAO , Murali T.G. Dhar , Ning Li , Jingwu Duan , Bin Jiang , Zhonghui Lu , Khehyong Ngu , William J. Pitts , Joseph A. Tino
IPC: C07D401/04 , C07D215/44 , C07D215/42 , C07D401/14 , C07D401/12 , C07D413/14 , C07D405/14 , C07D417/12 , C07D413/12 , C07D405/12 , C07D409/12 , C07D471/04
CPC classification number: C07D401/04 , C07D215/42 , C07D215/44 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR1 or N; B is CR3 or N; D is CR4 or N; L1 is —(CR7R7)m—; L2 is —(CR7R7)n—; and X, Z, R1, R2, R3, R4, R5, and R6 are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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60.发明授权Mutant receptors and their use in a nuclear receptor-based inducible gene expression system 有权突变体受体及其在基于核受体的诱导型基因表达系统中的应用
公开(公告)号：US09163256B2
公开(公告)日：2015-10-20
申请号：US11841464
申请日：2007-08-20
Applicant: Subba Reddy Palli , Mohan Basavaraju Kumar
Inventor： Subba Reddy Palli , Mohan Basavaraju Kumar
IPC: C12Q1/68 , C12N15/85 , A61K31/16 , A61K31/47 , C07D215/44 , C07H21/04 , C07K14/435 , C12N15/62 , C12N15/63
CPC classification number: C12N15/85 , A61K31/16 , A61K31/47 , C07D215/44 , C07H21/04 , C07K14/43536 , C12N15/62 , C12N15/63 , C12N15/635 , Y10S530/858
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Abstract translation: 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于诸如基因治疗，大规模生产蛋白质和 抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。
