公开(公告)号：US20120308592A1

公开(公告)日：2012-12-06

申请号：US13577484

申请日：2011-02-08

Applicant: Bryce Chackerian ,  David S. Peabody

Inventor： Bryce Chackerian ,  David S. Peabody

IPC: A61K39/12 ,  C12N15/63 ,  A61P31/20

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55566 ,  C12N7/00 ,  C12N2710/20023 ,  C12N2710/20034 ,  C12N2795/18123

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of human papillomavirus (HPV) infections and related disorders, including cervical cancer and persistent infections associated with HPV. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against HPV infection, confer immunity against HPV infection, protect against HPV infection, and reduce the likelihood of infection by HPV infection.

Abstract translation: 本发明提供免疫治疗和预防性噬菌体病毒样颗粒（VLP），其可用于治疗和预防人乳头状瘤病毒（HPV）感染和相关疾病，包括宫颈癌和与HPV相关的持续感染。 还提供了相关组合物（例如疫苗），核酸构建体和治疗方法。 本发明的VLP和相关组合物诱导针对HPV L2的高滴度抗体应答，并在体内保护免受HPV挑战。 VLP，含VLP的组合物和本发明的治疗方法诱导针对HPV感染的免疫原性应答，赋予HPV感染免疫，防止HPV感染，并降低HPV感染感染的可能性。

公开(公告)号：US08303789B1

公开(公告)日：2012-11-06

申请号：US12721860

申请日：2010-03-11

Applicant: Cornelius F. Ivory ,  Sang M. Han ,  Youn-Jin Oh

Inventor： Cornelius F. Ivory ,  Sang M. Han ,  Youn-Jin Oh

IPC: G01N27/414 ,  G01N27/447

CPC classification number: G01N33/6803 ,  G01N27/414 ,  G01N27/4473 ,  G01N27/44795

Abstract: Various embodiments provide an exemplary lab-on-a-chip (LOC) system that serves as an analytical tool and/or as a separation medium for an electrolyte solution including various charged molecular species. The LOC system can include an integrated nanofluidic FET device in combination with suitable analysis systems. By applying and controlling a longitudinal electric field and a transverse electric potential, the flow and the pH of the electrolyte solution in the nanofluidic channels can be controlled.

Abstract translation: 各种实施例提供了一种示例性的片上实验室（LOC）系统，其用作用于包括各种带电分子种类的电解质溶液的分析工具和/或作为分离介质。 LOC系统可以与合适的分析系统结合使用集成的纳米流体FET器件。 通过施加和控制纵向电场和横向电势，可以控制纳米流体通道中的电解质溶液的流动和pH。

公开(公告)号：US20120271023A1

公开(公告)日：2012-10-25

申请号：US13503067

申请日：2010-10-12

Applicant: David G. Whitten ,  Linnea K. Ista ,  Thomas S. Corbitt ,  Motokatsu Ogawa ,  Kirk S. Schanze ,  Gabriel P. Lopez ,  Ramanathan Nagarajan

Inventor： David G. Whitten ,  Linnea K. Ista ,  Thomas S. Corbitt ,  Motokatsu Ogawa ,  Kirk S. Schanze ,  Gabriel P. Lopez ,  Ramanathan Nagarajan

IPC: C08G83/00

CPC classification number: A01N43/90 ,  D06M13/513 ,  D06M14/02 ,  D06M14/04 ,  D06M14/06 ,  D06M14/08 ,  D06M15/227 ,  D06M16/00 ,  D06M23/005 ,  D06M2400/01 ,  Y10T442/20 ,  Y10T442/2525 ,  A01N25/10 ,  A01N25/34

Abstract: The present disclosure describes the manufacture and use of soft surfaces such as fabrics bearing surface-grafted antimicrobial polymers.

Abstract translation: 本公开描述了软表面的制造和使用，例如带有表面接枝的抗微生物聚合物的织物。

公开(公告)号：US08242003B1

公开(公告)日：2012-08-14

申请号：US13087240

申请日：2011-04-14

Applicant: Sang M. Han ,  Darin Leonhardt

Inventor： Sang M. Han ,  Darin Leonhardt

IPC: H01L21/20 ,  H01L21/36

CPC classification number: H01L21/02647 ,  H01L21/02381 ,  H01L21/0245 ,  H01L21/02455 ,  H01L21/02532 ,  H01L21/02538 ,  H01L21/02639

Abstract: Exemplary embodiments provide methods of forming semiconductor devices, by which defects formed upon nucleation and coalescence of semiconductor islands can be reduced or eliminated. In one embodiment, an annealing process can be performed prior to coalescence of the semiconductor islands into a continuous semiconductor layer. In another embodiment, high-quality Group III-V materials can be formed on the continuous semiconductor layer.

Abstract translation: 示例性实施例提供了形成半导体器件的方法，由此可以减少或消除半导体岛的成核和聚结所形成的缺陷。 在一个实施例中，可以在将半导体岛聚结成连续半导体层之前执行退火处理。 在另一个实施例中，可以在连续半导体层上形成高品质的III-V族材料。

公开(公告)号：US20120201268A1

公开(公告)日：2012-08-09

申请号：US13385016

申请日：2012-01-27

Applicant: Stephen Thomas Boyd ,  Wolfgang G. Rudolph

Inventor： Stephen Thomas Boyd ,  Wolfgang G. Rudolph

IPC: G01K17/00 ,  G01K7/36

CPC classification number: G01K7/36 ,  G01K13/006 ,  G01K17/00 ,  G01K2203/00

Abstract: An optical absorption calorimeter performs absorbance measurements at low cryogenic temperatures, such as above 0K to 5K (e.g. near liquid helium temperature), using high-resolution thermometry with SQUID readout to probe optical absorption to better than 1 ppb. This improved sensitivity yields improved performance in calorimetric absorption spectroscopy by lowering the required excitation power, improving the spectral resolution, and opening up the full spectrum, from near-IR to near-UV and beyond for analysis.

Abstract translation: 光吸收量热计在低温低温下进行吸光度测量，例如高于0K至5K（例如接近液氦温度），使用具有SQUID读数的高分辨率测温仪将光吸收探测到1 ppb以上。 这种改进的灵敏度通过降低所需的激发功率，改善光谱分辨率以及从近红外到近紫外以及更远的分析开放全谱，从而提高了量子吸收光谱学中的性能。

公开(公告)号：US20120022326A1

公开(公告)日：2012-01-26

申请号：US13131531

申请日：2009-12-01

Applicant: Francisco Jaime

Inventor： Francisco Jaime

IPC: A61M16/04 ,  A61B1/04

CPC classification number: A61M25/0147 ,  A61B1/267 ,  A61M16/0488

Abstract: An intubating stylet has a proximal end and a distal end. The intubating stylet includes a housing at the proximal end of the stylet and a tip portion at the distal end of the stylet. The tip portion has a distal gear at its proximal end. An outer shaft extends from the housing to the tip portion and contains an inner shaft defining a hollow lumen. A distal end of the inner shaft includes a proximal gear coupled with the distal gear of the tip portion such that rotation of the inner shaft causes articulation of the tip portion. The stylet further includes a drive member in the housing and a control member coupled with the drive member. The drive member is coupled to the inner shaft and configured to rotate the inner shaft, and the control member is configured to receive a user input and to translate the input into operation of the drive member.

Abstract translation: 插管探针具有近端和远端。 插管探针包括在探针的近端处的壳体和在探针的远端处的尖端部分。 尖端部分在其近端具有远端齿轮。 外轴从壳体延伸到尖端部分并且包含限定中空内腔的内轴。 内轴的远端包括与尖端部分的远端齿轮联接的近侧齿轮，使得内轴的旋转引起尖端部分的铰接。 探针还包括壳体中的驱动构件和与驱动构件联接的控制构件。 驱动构件联接到内轴并且构造成旋转内轴，并且控制构件构造成接收用户输入并将输入转换成驱动构件的操作。

公开(公告)号：US08071945B2

公开(公告)日：2011-12-06

申请号：US12184491

申请日：2008-08-01

Applicant: Sanjay Krishna ,  Majeed M. Hayat ,  J. Scott Tyo ,  Woo-Yong Jang

Inventor： Sanjay Krishna ,  Majeed M. Hayat ,  J. Scott Tyo ,  Woo-Yong Jang

IPC: G01J5/20

CPC classification number: H04N5/33 ,  G01J3/02 ,  G01J3/0259 ,  G01J3/32 ,  G01J3/46 ,  G01J3/465 ,  G01J3/50 ,  G01J2005/0077 ,  H01L27/14649 ,  H01L31/0352

Abstract: Exemplary embodiments provide an infrared (IR) retinal system and method for making and using the IR retinal system. The IR retinal system can include adaptive sensor elements, whose properties including, e.g., spectral response, signal-to-noise ratio, polarization, or amplitude can be tailored at pixel level by changing the applied bias voltage across the detector. “Color” imagery can be obtained from the IR retinal system by using a single focal plane array. The IR sensor elements can be spectrally, spatially and temporally adaptive using quantum-confined transitions in nanoscale quantum dots. The IR sensor elements can be used as building blocks of an infrared retina, similar to cones of human retina, and can be designed to work in the long-wave infrared portion of the electromagnetic spectrum ranging from about 8 μm to about 12 μm as well as the mid-wave portion ranging from about 3 μm to about 5 μm.

Abstract translation: 示例性实施方案提供用于制备和使用IR视网膜系统的红外（IR）视网膜系统和方法。 IR视网膜系统可以包括自适应传感器元件，其特性包括例如光谱响应，信噪比，偏振或幅度可以通过改变跨越检测器的所施加的偏置电压来在像素级别进行调整。 可以通过使用单个焦平面阵列从IR视网膜系统获得“彩色”图像。 IR传感器元件可以在纳米尺度量子点中使用量子限制过渡进行光谱，空间和时间适应。 IR传感器元件可以用作红外视网膜的结构单元，类似于人视网膜的锥体，并且可以设计成在约8μm至约12μm范围内的电磁光谱的长波红外部分中工作 作为约3μm至约5μm的中波部分。

公开(公告)号：US20110253140A1

公开(公告)日：2011-10-20

申请号：US13056588

申请日：2009-07-30

Applicant: Hugh D.C. Smyth ,  Martin Donovan

Inventor： Hugh D.C. Smyth ,  Martin Donovan

IPC: A61M15/00 ,  A61P11/00 ,  A61K9/16

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

Abstract translation: 干粉吸入器可以包括配置成容纳包含载体颗粒和工作剂颗粒的制剂的药物室，构造成将工作剂颗粒流向使用者的接口管和靠近接口管的保持构件。 保持构件的尺寸和布置被设计成防止基本上所有的载体颗粒流向使用者，同时允许工作剂颗粒流向使用者。 吸入器可以包括包含用于将工作剂递送到患者的肺部系统的载体颗粒的制剂。 载体颗粒的平均筛子直径可以大于约500μm。 载体颗粒可以是聚苯乙烯，PTFE，硅玻璃和硅胶或玻璃之一。

公开(公告)号：US08039854B2

公开(公告)日：2011-10-18

申请号：US12399273

申请日：2009-03-06

Applicant: Stephen D. Hersee ,  Xin Wang ,  Xinyu Sun

Inventor： Stephen D. Hersee ,  Xin Wang ,  Xinyu Sun

IPC: H01L29/205 ,  H01L33/00

CPC classification number: H01L29/413 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  C30B29/60 ,  H01L21/0237 ,  H01L21/02458 ,  H01L21/0254 ,  H01L21/02573 ,  H01L21/02603 ,  H01L21/02609 ,  H01L21/02612 ,  H01L21/0262 ,  H01L21/02636 ,  H01L21/02639 ,  H01L21/02642 ,  H01L29/045 ,  H01L29/0676 ,  H01L29/2003 ,  H01L29/775 ,  H01L31/0304 ,  H01L31/035236 ,  H01L31/184 ,  H01L33/18 ,  H01L33/24 ,  H01L2221/1094 ,  H01L2924/0002 ,  H01S5/1042 ,  H01S5/1835 ,  H01S5/18369 ,  H01S5/3428 ,  Y02E10/544 ,  Y02P70/521 ,  Y10S977/762 ,  Y10S977/816 ,  Y10T428/24612 ,  H01L2924/00

Abstract: Exemplary embodiments provide semiconductor devices including high-quality (i.e., defect free) group III-N nanowires and uniform group III-N nanowire arrays as well as their scalable processes for manufacturing, where the position, orientation, cross-sectional features, length and the crystallinity of each nanowire can be precisely controlled. A pulsed growth mode can be used to fabricate the disclosed group III-N nanowires and/or nanowire arrays providing a uniform length of about 10 nm to about 1000 microns with constant cross-sectional features including an exemplary diameter of about 10-1000 nm. In addition, high-quality GaN substrate structures can be formed by coalescing the plurality of GaN nanowires and/or nanowire arrays to facilitate the fabrication of visible LEDs and lasers. Furthermore, core-shell nanowire/MQW active structures can be formed by a core-shell growth on the nonpolar sidewalls of each nanowire.

Abstract translation: 示例性实施例提供包括高质量（即，无缺陷）III-N族纳米线和均匀III-N纳米线阵列的半导体器件及其可制造的可扩展工艺，其中位置，取向，横截面特征，长度和 可以精确地控制每个纳米线的结晶度。 可以使用脉冲生长模式来制造公开的提供约10nm至约1000微米的均匀长度的III-N族纳米线和/或纳米线阵列，其具有恒定的横截面特征，包括约10-1000nm的示例性直径。 此外，可以通过聚结多个GaN纳米线和/或纳米线阵列来形成高质量的GaN衬底结构，以便制造可见的LED和激光器。 此外，核 - 壳纳米线/ MQW活性结构可以通过在每个纳米线的非极性侧壁上的核 - 壳生长形成。

公开(公告)号：US08021872B2

公开(公告)日：2011-09-20

申请号：US12924542

申请日：2010-09-29

Applicant: Larry A Sklar ,  Bruce S Edwards ,  Frederick W Kuckuck

Inventor： Larry A Sklar ,  Bruce S Edwards ,  Frederick W Kuckuck

IPC: C12M1/34 ,  G01N33/53

CPC classification number: G01N15/1436 ,  B01L3/5085 ,  G01N15/1404 ,  G01N15/1459 ,  G01N21/6428 ,  G01N21/6486 ,  G01N35/0099 ,  G01N35/085 ,  G01N35/1095 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1402 ,  G01N2015/1413 ,  G01N2015/1477 ,  G01N2015/149 ,  G01N2021/6439 ,  G01N2201/06113 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.