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61.发明授权
公开(公告)号：US3912756A
公开(公告)日：1975-10-14
申请号：US45025474
申请日：1974-03-11
IPC分类号： C07D209/42 , C07D213/82 , C07D215/48 , C07D221/16 , C07D231/14 , C07D231/16 , C07D261/18 , C07D277/20 , C07D277/56 , C07D333/38 , C07D209/18 , C07D213/56
CPC分类号： C07D213/82 , C07D209/42 , C07D215/48 , C07D221/16 , C07D231/14 , C07D261/18 , C07D277/56 , C07D333/38 , Y10S514/824
摘要： Novel phenoxyalkyl-carboxylic acid derivatives of the formula
wherein R1 and R2, which may be the same or different, are hydrogen or methyl; N IS 1 OR 2; Z is hydroxyl or alkoxy; and Y is a 5- or 6-membered heterocyclic ring containing, as hetero atoms, 1 or 2 sulfur, oxygen or nitrogen atoms, which heterocyclic ring may be substituted by halogen atoms or lower alkyl, alkoxy or alkoxyalkoxy radicals and may also contain a fused benzene nucleus, which can be substituted by halogen atoms or alkoxy or an alkylene radical; AND THE PHARMOCOLOGICALLY COMPATIBLE SALTS THEREOF, ARE OUTSTANDINGLY EFFECTIVE AS SERUM LIPID DEPRESSANTS AND ARE THUS EFFECTIVE THERAPEUTIC AGENTS IN THE TREATMENT OF ATHEROSCLEROSIS.摘要翻译： 式R1 | Y-CO-NH-（CH2）n -O-C-CO-Z | R2的新型苯氧基烷基 - 羧酸衍生物，其中可以相同或不同的R 1和R 2是氢或甲基; N IS 1 OR 2; Z是羟基或烷氧基; Y为5或6元杂环，杂环为1或2个硫，氧或氮原子，该杂环可被卤素原子或低级烷基，烷氧基或烷氧基烷氧基取代，也可含有 稠合的苯核，其可以被卤素原子或烷氧基或亚烷基取代; 并且其药理学兼容的盐，作为血清脂质沉着剂是非常有效的，并且是有效的治疗药物治疗甲状腺功能亢进症。
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公开(公告)号：US3912588A
公开(公告)日：1975-10-14
申请号：US41152673
申请日：1973-10-31
CPC分类号： C12Q1/34 , C12N9/78 , C12N9/86 , C12Q1/50 , G01N2333/9123 , G01N2333/978 , G01N2333/986 , Y10S435/815 , Y10S435/816 , Y10S435/824 , Y10S435/829 , Y10S435/933
摘要： Creatinine amidohydrolase and creatine amidinohydrolase are prepared by a process comprising culturing a microorganism in a creatinine-containing medium, digesting same, obtaining the creatinine amidohydrolase in substantially pure form from the water-soluble digestion fraction and, optionally separating by ion exchange chromatography any creatine amidinohydrolase present.
摘要翻译： 肌酸酐酰胺水解酶和肌酸酰氨基水解酶通过包括在含肌酸酐的培养基中培养微生物，消化其的方法制备，从水溶性消化部分获得基本上纯的形式的肌酸酐酰胺水解酶，以及任选通过离子交换色谱法分离任何肌酸脒基水解酶 当下。
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公开(公告)号：US3885026A
公开(公告)日：1975-05-20
申请号：US39579673
申请日：1973-09-10
发明人： HEINEMANN HELMUT , ROTHE WERNER
CPC分类号： A61K9/2095 , Y10S516/01
摘要： In the production of tablets which are to undergo disintegration in use wherein the tablet components are mixed and pressed into predetermined shape, the improvement which comprises incorporating into the mix at least one inert readily volatilizable solid adjuvant, pressing the mix into shape, and thereafter volatilizing the adjuvant, whereby the resulting tablets are porous, strong, shape retaining and readily disintegratable. Volatilization can be effected by sublimation or application of vacuum. The adjuvant preferably comprises urethane, urea, ammonium carbonate, ammonium bicarbonate, hexamethylene-tetramine, benzoic acid, phthalic anhydride, naphthalene or camphor present in about 5 to 50 percent, especially about 10 to 30 percent, by weight of the total tablet mix.
摘要翻译： 在将片剂成分混合并压制成规定形状的片剂中进行崩解的片剂的制造中，包括将混合物中至少一种惰性容易挥发的固体佐剂，将混合物压制成型，然后挥发 佐剂，由此得到的片剂是多孔的，坚固的，形状保持的并且易于分解。 挥发可通过升华或应用真空来实现。 佐剂优选包含占总片剂混合物重量的约5至50重量％，特别是约10至30重量％的氨基甲酸酯，尿素，碳酸铵，碳酸氢铵，六亚甲基四胺，苯甲酸，邻苯二甲酸酐，萘或樟脑。
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公开(公告)号：US3880829A
公开(公告)日：1975-04-29
申请号：US39385973
申请日：1973-09-04
IPC分类号： C07H19/167 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P3/06 , C07D487/04 , C07H19/16 , C07D51/54
CPC分类号： C07H19/16
摘要： WHEREIN R1 is lower alkyl substituted by at least one of hydroxyl, alkoxy or acyloxy; or is cycloalkyl or straight-chained or branched lower alkenyl; R2 and R3 are hydrogen, halogen, or nitro or lower alkyl, alkoxy or alkylthio and R4 is hydrogen or acyl; when R4 is acyl, R1 can also be lower alkyl; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; EXHIBITS SHOWN ANTI-LIPOLYTIC, ANTI-HYPERLIPAEMIC AND ANTIHYPERCHOLESTEROLAEMIC ACTION.
New N(6)-disubstituted adenosine coupound of the formula:摘要翻译： 新型N（6） - 二取代腺苷配合物：
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公开(公告)号：US3862012A
公开(公告)日：1975-01-21
申请号：US38002073
申请日：1973-07-17
发明人： STORK HARALD
摘要： Uric acid is determined by contacting a sample suspected of containing uric acid with a phosphate buffer, an NADH solution, ethanol, alcohol dehydrogenase and catalase in the presence of air to form a reaction mixture containing 0.3 to 0.7 volume percent alcohol, measuring a first extinction value, adding uricase to the reaction mixture, measuring a second extinction value spectrophotometrically and taking the difference between the extinction values as a measure of the initial uric acid content in the sample.
摘要翻译： 通过在空气存在下将涉嫌含有尿酸的样品与磷酸盐缓冲液，NADH溶液，乙醇，醇脱氢酶和过氧化氢酶接触来测定尿酸，以形成含有0.3至0.7体积％酒精的反应混合物，测量第一次灭绝 值，向反应混合物中加入尿酸酶，通过分光光度法测量第二消光值，并将消光值之间的差作为样品中初始尿酸含量的量度。
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公开(公告)号：US3843393A
公开(公告)日：1974-10-22
申请号：US28885872
申请日：1972-09-13
发明人： GROPPENBACHER G , SCHALK H , SCHELLHORN J , RIECKMANN P , ROTHE W
摘要： 1. IN THE PROCESS OF COATING TABLET CORES OR THE LIKE WITH A COATING COMPRISING PLACING SAID CORES IN A CONTAINER, ROTATING SAID CONTAINER TO MOVE SAID CORES ABOUT, SUPPLYING A SUSPENSION OR SOLUTION OF COATING MATERIAL TO SAID CONTAINER TO COAT SAID CORES AND SUPPLYING A DYRING GAS TO SAID CONTAINER TO DRY THE COATING ON SAID CORES, THE IMPROVEMENT WHICH COMPRISES INTRODUCING SAID DRYING GAS INTO THE BODY OF MOVING TABLET CORES BELOW THE LEVEL THEREOF IN SUCH MANNER THAT A SUBSTANTIALLY TABLET-FREE GAS SPACE IS FORMED JUST BEYOND THE POINT OF DISCHARGE OF SAID GAS, SAID GAS BEING DIRECTED IN THE MAIN DIRECTION OF MOVEMENT OF THE TABLET CORES, SPRAYING OF SAID COATING MATERIAL INTO SAID GAS SPACE TAKING PLACE IN A DIRECTION SUBSTANTIALLY PARALLEL TO THE DIRECTION OF DISCHARGE OF SAID GAS.
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公开(公告)号：US3819487A
公开(公告)日：1974-06-25
申请号：US18164071
申请日：1971-09-17
发明人： BERNT E , BERGMEYER H , BEAUCAMP K , GRASSL M , GRUBER W
IPC分类号： B01D46/52 , C07H19/207 , C12Q1/00 , G01N31/14
CPC分类号： C12Q1/008 , C07H19/207
摘要： Storage stable reduced nicotinamide-adenine-dinucleotide (NADH) compositions, which do not form dehydrogenase inhibitors of prolonged time periods, are produced by forming a dilute aqueous solution of inhibitor-free NADH and maintaining this solution in a thin layer vacuum.
摘要翻译： 通过形成稀释的不含抑制剂的NADH的水溶液并将该溶液保持在薄层真空中来制备不延长时间段的脱氢酶抑制剂的储存稳定的还原型烟酰胺 - 腺嘌呤二核苷酸（NADH）组合物。
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公开(公告)号：US3810896A
公开(公告)日：1974-05-14
申请号：US24213472
申请日：1972-04-07
IPC分类号： C07D311/30 , C07D51/70
CPC分类号： C07D311/30
摘要： CERTAIN NOVEL 4-(FLAVON-7-OYLOXY)-ALKYL)-PIPERAZINE COMPOUNDS OF THE FORMULA
2-PHENYL,7-((4-R-PIPERAZINO)-(CH2)N-O-)-4H-CHROMEN-4-ONE
WHEREIN R IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS BEING HALOGEN ATOMS OR LOWER ALKYL OR ALKOXY RADICALS, E.G., OF FROM 1 TO 6 CARBON ATOMS, AND N IS 1, 2 OR 3; AND THE PHRMACOLOGICALLY COMPATIBLE SALTS THEREOF. HAVE OUTSTANDING ANTI-EDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.-
69.发明授权Carrier-bound enzyme prepared by reacting an enzyme with a compound containing an epoxy group and an unsaturated double bond and then polymerizing with an olefinic monomer 失效通过用包含环氧基团和不饱和双键的化合物反应酶，然后与烯烃单体聚合制备的载体环化酶
公开(公告)号：US3806417A
公开(公告)日：1974-04-23
申请号：US25896872
申请日：1972-06-02
发明人： NELBOECK HOCHSTETTER M , BEAUCAMP K , BERGMEYER H , BOTSCH K , JAWOREK D
IPC分类号： C08H1/00 , C08F289/00 , C12N11/08 , C07G7/02
CPC分类号： C08F289/00 , C12N11/08 , Y10S530/815
摘要： CARRIER-BOUND PROTEINS ARE PREPARED BY REACTING A PROTEIN IN AQUEOUS SOLUTION WITH A COMPOUND HAVING AT LEAST ONE EPOXY GROUP AND AT LEAST ONE ADDITIONAL FUNCTIONAL GROUP CAPABLE OF PRODUCING A BOND WITH A CARRIER MATERIAL, AND REACTING THE RESULTING PRODUCT WITH A CARRIER MATERIAL, OPTIONALLY FORMING THE CARRIER MATERIAL IN SITU BY POLYMERIZATION OF A MONOMER OR MONOMER MIXTURE.
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公开(公告)号：US3802340A
公开(公告)日：1974-04-09
申请号：US26696072
申请日：1972-06-28
发明人： BRAUN H
摘要： Apparatus for the imprinting of dragees wherein the apparatus comprises, in combination, a feed hopper, a rotating cylindrical transport drum having a plurality of receiving apertures adapted to receive dragees from said hopper and to hold dragees, a set of printing rolls disposed on either side of said transport drum to lightly press against both sides of the dragees in the apertures of the transport drum, and inkers for said printing rolls.
摘要翻译： 用于压印糖衣的装置，其中所述装置组合包括进料斗，旋转的圆柱形输送滚筒，其具有适于从所述料斗接收糖锭并保持糖锭的多个接收孔，一组设置在任一侧的印刷辊 的所述运送滚筒，以轻轻按压输送滚筒的孔中的糖锭的两侧，以及用于所述印刷辊的墨水。
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