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135 条记录 (耗时 0.031 秒)

    SUBSTITUTED ARYLOXYPROPYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY
    63.
    发明申请
    SUBSTITUTED ARYLOXYPROPYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 审中-公开
    具有丝氨酸和/或非诺贝宁活性的取代的芳基丙烯酰胺

    公开(公告)号：US20070155820A1

    公开(公告)日：2007-07-05

    申请号：US11562890

    申请日：2006-11-22

    申请人： Thomas Gant ,  Sepehr Sarshar

    发明人： Thomas Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/381 ,  A61K31/138 ,  C07D333/22 ,  C07C217/30

    CPC分类号： C07D333/20 ,  C07B59/001 ,  C07B59/002 ,  C07B2200/07 ,  C07C217/48 ,  C07D333/24

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。

    SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY
    64.
    发明申请
    SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 有权
    具有丝氨酸和/或非诺贝宁活性的取代的苯乙烯

    公开(公告)号：US20070149622A1

    公开(公告)日：2007-06-28

    申请号：US11565451

    申请日：2006-11-30

    申请人： Thomas Gant ,  Sepehr Sarshar

    发明人： Thomas Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/137

    CPC分类号： A61K31/137 ,  A61K45/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C65/21 ,  C07C217/74 ,  C07C235/34 ,  C07C255/37 ,  C07C2601/14

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。

    Modulators of proteins with phosphotyrosine recognition units
    65.
    发明授权
    Modulators of proteins with phosphotyrosine recognition units 失效
    具有磷酸酪氨酸识别单元的蛋白质的调节剂

    公开(公告)号：US6150532A

    公开(公告)日：2000-11-21

    申请号：US210076

    申请日：1998-12-11

    申请人： Adnan Mjalli ,  Sepehr Sarshar ,  Xiaodong Cao ,  Farid Bakir

    发明人： Adnan Mjalli ,  Sepehr Sarshar ,  Xiaodong Cao ,  Farid Bakir

    IPC分类号： A61K31/495 ,  C07D241/38 ,  C07D263/34 ,  C07D263/44 ,  C07D263/48 ,  C07D413/04

    CPC分类号： A61K31/495 ,  C07D241/42 ,  C07D471/04

    摘要： The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their use in diagnosis. The invention relates to modulation of the activity of molecules with phosphotyrosine recognition units, including protein tyrosine phosphatases (PTPases) and proteins with Src-homology-2 domains, in in vitro systems, microorganism, eukaryoic cells, whole animals and human being. R' and R" are independently selected from the group consisting of hydrogen, halo, cyano, nitro, trihalomethyl, alkyl, arylalkyl. R'" is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, arylalkyl. X is aryl. Y is selected from hydrogen or ##STR1## wherein (*) indicates a potential point of attachment to X.

    摘要翻译： 本发明涉及具有式（A1）所示的一般结构的新型蛋白质酪氨酸磷酸酶调节化合物，其制备方法，包含该化合物的组合物，其用于治疗人和动物病症的用途，用于其纯化 的蛋白质或糖蛋白，以及它们在诊断中的用途。 本发明涉及在体外系统，微生物，真核细胞，整个动物和人中调节具有磷酸酪氨酸识别单元的分子的活性，包括蛋白酪氨酸磷酸酶（PTP酶）和具有Src-同源性-2结构域的蛋白质。 R'和R“独立地选自氢，卤素，氰基，硝基，三卤代甲基，烷基，芳基烷基。 R“选自氢，烷基，取代的烷基，芳基，芳基烷基。 X是芳基。 Y选自氢或其中（*）表示与X连接的潜在点。

    Modulators of proteins with phosphotryrosine recognition units
    66.
    发明授权
    Modulators of proteins with phosphotryrosine recognition units 失效
    具有磷酸基酪氨酸识别单元的蛋白质调节剂

    公开(公告)号：US5753687A

    公开(公告)日：1998-05-19

    申请号：US766114

    申请日：1996-12-16

    申请人： Adnan Mjalli ,  Sepehr Sarshar ,  Xiaodong Cao ,  Farid Bakir

    发明人： Adnan Mjalli ,  Sepehr Sarshar ,  Xiaodong Cao ,  Farid Bakir

    IPC分类号： A61K31/415 ,  C07D233/54 ,  C07D233/56 ,  C07D233/66

    CPC分类号： A61K31/415 ,  C07D233/54 ,  C07D233/56 ,  C07D233/66

    摘要： Y--X--C(R').dbd.C(R")COOR'" (A1) The present invention relates to novel protein tyrosine phosphatase modulating compounds having the general structure shown in Formula (A1), to methods for their preparation, to compositions comprising the compounds, to their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to their use in diagnosis. The invention relates to modulation of the activity of molecules with phosphotyrosine recognition units, including protein tyrosine phosphatases (PTPases) and proteins with Src-homology-2 domains, in in vitro systems, microorganisms, eukaryoic cells, whole animals and human beings. R' and R" are independently selected from the group consisting of hydrogen, halo, cyano, nitro, trihalomethyl, alkyl, arylalkyl. R'" is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, arylalkyl. X is aryl. Y is selected from hydrogen or ##STR1## wherein (*) indicates a potential point of attachment to X.

    摘要翻译： YXC（R'）= C（R“）COOR”'（A1）本发明涉及具有式（A1）所示的一般结构的新的蛋白质酪氨酸磷酸酶调节化合物及其制备方法， 该化合物用于治疗人和动物疾病，用于蛋白质或糖蛋白的纯化及其在诊断中的应用。 本发明涉及在体外系统，微生物，真核细胞，整个动物和人类中调节具有磷酸酪氨酸识别单元的分子的活性，包括蛋白酪氨酸磷酸酶（PTP酶）和具有Src同源性-2结构域的蛋白质。 R'和R“独立地选自氢，卤素，氰基，硝基，三卤代甲基，烷基，芳基烷基。 R“选自氢，烷基，取代的烷基，芳基，芳基烷基。 X是芳基。 Y选自氢或 其中（*）表示与X的连接点。

    Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
    67.
    发明授权
    Preparation and utility of substituted imidazopyridine compounds with hypnotic effects 有权
    具有催眠作用的取代咪唑并吡啶化合物的制备和应用

    公开(公告)号：US08101633B2

    公开(公告)日：2012-01-24

    申请号：US12552254

    申请日：2009-09-01

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/437 ,  A61K31/4745 ,  A61K31/4184

    CPC分类号： C07D471/04

    摘要： The present disclosure is directed to modulators of GABAA receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of sleep disorders and/or for providing a patient in need with a hypnotic, anxiolytic or anti-convulsive effect are described.

    摘要翻译： 本公开涉及GABA A受体及其药学上可接受的盐和前药的调节剂，其化学合成以及这些化合物用于治疗和/或治疗睡眠障碍和/或提供需要的患者的医学用途 描述了催眠，抗焦虑或抗惊厥作用。

    SUBSTITUTED ARYLOXYPROPYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY
    69.
    发明申请
    SUBSTITUTED ARYLOXYPROPYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 审中-公开
    具有丝氨酸和/或非诺贝宁活性的取代的芳基丙烯酰胺

    公开(公告)号：US20110136914A1

    公开(公告)日：2011-06-09

    申请号：US12895318

    申请日：2010-09-30

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/138 ,  C07C217/62 ,  A61P25/30 ,  A61P25/32 ,  A61P25/36 ,  A61P25/00 ,  A61P25/24 ,  A61P3/04 ,  A61P29/00 ,  A61P9/10 ,  A61P13/00

    CPC分类号： C07D333/20 ,  C07B59/001 ,  C07B59/002 ,  C07B2200/07 ,  C07C217/48 ,  C07D333/24

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。