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公开(公告)号:US11180556B2
公开(公告)日:2021-11-23
申请号:US15959331
申请日:2018-04-23
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , INSTITUT JEAN PAOLI & IRENE CALMETTES , UNIVERSITE D'AIX-MARSEILLE , Universite Claude Bernard—Lyon 1 , Centre Leon Berard
Inventor: Julien Faget , Christophe Caux , Christine Menetrier-Caux , Jacques Nunes , Daniel Olive
IPC: C07K16/28 , A61K39/395 , G01N33/569 , G01N33/574 , A61K39/00
Abstract: The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4− T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.
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公开(公告)号:US11112692B2
公开(公告)日:2021-09-07
申请号:US16623152
申请日:2018-06-08
Applicant: UNIVERSITE D'AIX-MARSEILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE TOULON
Inventor: David Grosso , Thomas Bottein
IPC: G03F7/00
Abstract: Microtransfer molding process and patterned substrate obtainable therefrom The present invention pertains to the field of nanoimprint lithography (NIL) processes and more specifically to a MicroTransfer Molding process used for providing a sol-gel patterned layer on a substrate without any residual layer. The process comprises the following successive steps: (a) impregnating a soft mold with a sol-gel layer coated on a first substrate, under conditions of a relative solvent pressure adjusted such that the layer swells by vapor absorption between 10 and 60% vol., so as to fill the mold under the action of capillary forces, (b) removing the first substrate, (c) if needed, equilibrating the gel within the mold cavities, under a relative solvent pressure between 0 and 95%, in order to allow it to swell, (d) applying the swollen gel onto a second substrate to be patterned, (e) thermally treating this assembly so as to rigidify the gel, (f) removing the mold, and (g) curing the gel into a ceramic, thus forming a patterned substrate.
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63.
公开(公告)号:US20210086883A1
公开(公告)日:2021-03-25
申请号:US16954509
申请日:2018-12-12
Inventor: Mathieu COULANGE , Pierre MICHELET
Abstract: A system for controlling the exhalation pressure of a diver for diving equipment with a ventilation circuit, includes a unidirectional valve acting on an exhalation outlet of the ventilation circuit, and a brake configured to exert an adjustable constraint on the unidirectional valve in order to control the pressure of the gas from the exhalation outlet so as to generate a positive exhalation pressure in the ventilation circuit of the equipment and thus prevent or treat immersion pulmonary edemas.
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公开(公告)号:US20210063511A1
公开(公告)日:2021-03-04
申请号:US17043712
申请日:2019-03-27
Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , ECOLE CENTRALE DE MARSEILLE , UNIVERSITE D'AIX-MARSEILLE (AMU)
Inventor: Abdeddaim Redha , Anne-Lise Adenot-Engelvin , Marc Dubois , Stefan Enoch , Nicolas Mallejac , Zo Raolison , Pierre Sabouroux , Alexandre Vignaud
IPC: G01R33/28 , G01R33/565
Abstract: The invention relates to a material for use as a pad in high field and/or very high field magnetic resonance imaging instrument, comprising at least one polar solvent having a melting point of 14° C. to 50° C., a dispersant and a dielectric charge. The invention relates also to a pad used in field of high field and/or very high field magnetic resonance imaging made of at least such a material.
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65.
公开(公告)号:US20210018744A1
公开(公告)日:2021-01-21
申请号:US16091200
申请日:2017-04-04
Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS , Universite d'Aix-Marseille (AMU) , Ecole Centrale de Marseille (ECM)
Inventor: Hervé Rigneault , Esben Ravn Andresen , Siddarth Sivankutty
Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres. The optical phase control device comprises at least one spatial light modulator (30) adapted to apply a phase shift to each of the elementary beams and control means (60) for controlling the spatial light modulator allowing application of a phase shift to each of the elementary beams to form an illumination beam with a determined phase function at the distal end of the multimode optical fibre section (50).
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公开(公告)号:US20200338095A1
公开(公告)日:2020-10-29
申请号:US16758292
申请日:2018-10-22
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE D'AIX MARSEILLE
Inventor: Pierre SZEPETOWSKI , Robin CLOAREC , Sylvian BAUER , Nadine BRUNEAU
IPC: A61K31/65 , A61K31/663 , A61P25/28
Abstract: The present invention relates the field of CMV and CMV related diseases. Using a powerful rat model of CMV infection of the embryonic brain, the inventors have looked for the existence of postnatal neurological and neurosensory manifestations, and have tested whether the early pharmacological targeting of microglia during pregnancy impacts on postnatal phenotypes. Particularly, the inventors tested the clodronate and the doxycycline and showed that these compounds improve the postnatal outcome of the baby. Thus, the invention relates to a compound which modifies the microglia for use in the treatment of CMV related diseases in a subject in need thereof.
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67.
公开(公告)号:US10809269B2
公开(公告)日:2020-10-20
申请号:US15568097
申请日:2016-04-21
Applicant: UNIVERSITE D'AIX-MARSEILLE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE MONTPELLIER , CENTRE HOSPITALIER UNIVERSITAIRE DE NIMES , ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE
Inventor: Nathalie Bardin , Marcel Blot-Chabaud , Sylvie Bouvier , Odile Lacroix , Francoise Dignat-George , Jean-Christophe Raymond Gris
IPC: G01N33/68 , A61B17/435
Abstract: The present invention relates to the field of human fertility treatment. The present invention more specifically relates to the identification of soluble CD146 (sCD146) as a biomarker which, when measured in an embryo culture medium, can be used to determine whether the embryo can be selected for implantation in the uterus of a mammal or not. The present invention thus provides a new tool and related kits to (pre)select embryo eligible for implantation. The invention also relates to methods for promoting pregnancy in a human who undergoes embryo transfer.
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公开(公告)号:US10755823B2
公开(公告)日:2020-08-25
申请号:US15565119
申请日:2016-04-08
Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , UNIVERSITE D'AIX-MARSEILLE
Inventor: Michel Carette , Abdallah Lyoussi , Julie Brun , Christelle Reynard-Carette , Jean-François Villard , Philippe Guimbal
Abstract: A sample holder for the measurement of nuclear heating in a nuclear reactor, comprises: a body configured to contain a heat-sensitive sample along a longitudinal axis; and means for removing heat from the body to the exterior of the sample holder, wherein the means for removing heat from the body to the exterior of the sample holder comprise: a peripheral structure located on the periphery of the body; and a central structure mechanically linking the body and the peripheral structure, the central linking structure being configured to transfer heat radially, i.e. perpendicularly to the longitudinal axis, between the body and the peripheral structure. A calorimeter cell for the measurement of nuclear heating in a nuclear reactor, comprises: at least one sample holder; a seal-tight casing in which the sample holder is placed; and temperature-measuring means.
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公开(公告)号:US10732307B2
公开(公告)日:2020-08-04
申请号:US15537158
申请日:2015-12-21
Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , UNIVERSITE D'AIX-MARSEILLE
Inventor: Laurent Ottaviani , Vanessa Vervisch , Fatima Issa , Abdallah Lyoussi
IPC: G01T3/08 , H01L31/118 , G01T7/00
Abstract: A method for producing a device for detecting flux of neutrons with parameters in predetermined ranges, including: one phase of determining parameters, including: simulating penetration of a flux of incident neutrons with parameters in the predetermined ranges through a modelled stack including in succession and in order at least: one first electrode; one substrate including: a first layer; and a second layer; and one second electrode; and simulating at least one defect peak created in the first layer by vacancies and/or ionization of the particles generated by collisions between neutrons of the flux of incident neutrons and atoms of the second dopant species; and identifying depth of the defect peak closest the interface between the first and second layers of the modelled stack.
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公开(公告)号:US20190254585A1
公开(公告)日:2019-08-22
申请号:US16316803
申请日:2016-07-18
Applicant: UNIVERSITE D'AIX MARSEILLE (AMU) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE (AP-HM) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Inventor: Viktor Jirsa , Christophe Bernard , Fabrice Bartolomei , Maxime Guye
IPC: A61B5/00 , G16H50/50 , A61B34/10 , A61B5/0478
Abstract: The invention relates to modulating epileptogenicity in a brain of an epileptic patient. The method according to the invention comprises the steps of: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading said models in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in said data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing said at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.
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