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74 条记录 (耗时 0.029 秒)

    Process for preparing long-chain dicarboxylic acids
    61.
    发明授权
    Process for preparing long-chain dicarboxylic acids 有权
    制备长链二羧酸的方法

    公开(公告)号：US08383373B2

    公开(公告)日：2013-02-26

    申请号：US12096091

    申请日：2005-12-30

    申请人： Ahmed Kamal ,  Sheelu Gurrala ,  Wasantrao Nitin Fadnavis

    发明人： Ahmed Kamal ,  Sheelu Gurrala ,  Wasantrao Nitin Fadnavis

    IPC分类号： C12N1/00 ,  C12P1/02 ,  C12P7/00 ,  C12P7/40 ,  C12P7/46

    CPC分类号： C12P7/44

    摘要： The present invention particularly discovered strains that are capable of producing a long-chain dicarboxylic acid by culturing microorganisms belonging to Candida vini Candida entamophila, Candida blankii and Pichia farinosa which has the ability to produce a long-chain dicarboxylic acid in a liquid medium containing a straight-chain saturated hydrocarbon (tridecane) as substrate.

    摘要翻译： 本发明特别地发现能够通过培养属于假丝酵母假丝酵母假单胞菌，假丝酵母​​和毕赤酵母的微生物能够生产长链二羧酸的菌株，其能够在含有 直链饱和烃（十三烷）作为底物。

    Novel Anthranilic Acid Derivative as Potential Anticancer Agent and a Process for the Preparation Thereof
    67.
    发明申请
    Novel Anthranilic Acid Derivative as Potential Anticancer Agent and a Process for the Preparation Thereof 有权
    新型邻氨基苯甲酸衍生物作为潜在的抗癌剂及其制备方法

    公开(公告)号：US20100016589A1

    公开(公告)日：2010-01-21

    申请号：US12307570

    申请日：2008-03-13

    申请人： Ahmed Kamal ,  Bandari Rajendra Prasad

    发明人： Ahmed Kamal ,  Bandari Rajendra Prasad

    IPC分类号： C07D403/04 ,  C07D401/04 ,  C07D241/04 ,  C07C233/00

    CPC分类号： C07D295/192 ,  C07C237/44 ,  C07C317/40 ,  C07C2603/18 ,  C07D213/74 ,  C07D237/34 ,  C07D239/42 ,  C07D239/94 ,  C07D295/08 ,  C07D295/18

    摘要： The present invention provides novel anthranilic acid derivative useful as potential anticancer agent. More particularly, the present invention relates novel anthranilic acid derivative of general formula (8), R′=alkyl-2-methoxyphenyl piperazine (or) benzyl, R=2 methoxy phenyl, piperazine, 2-pyridyl piperazine, 2-pyrimidyl piperazine, 4-quinazolinyl piperazine, 9H-9-fluorenylamine, 4-{(2{amino-5-(methoxy)-4-[(phenylmethyl)oxy]phenyl}carbonyl)hexahydro-1-pyrazinyl], and [(4[2 amino-4-(benzyloxy)-5-methoxybenzoyl]aminophenyl)sulfonyl]-4-benzamine; X═H (or) pyrazine-2-carbonyl. The present invention also provides a process for the preparation of novel anthranilic acid derivative of general formula (8), which is useful as potential anticancer agent.

    摘要翻译： 本发明提供可用作潜在抗癌剂的新型邻氨基苯甲酸衍生物。 更具体地说，本发明涉及通式（8）的新型邻氨基苯甲酸衍生物，R'=烷基-2-甲氧基苯基哌嗪（或）苄基，R = 2-甲氧基苯基，哌嗪，2-吡啶基哌嗪，2-嘧啶基哌嗪， 4-喹唑啉基哌嗪，9H-芴基胺，4 - {（2 {氨基-5-（甲氧基）-4 - [（苯基甲基）氧基]苯基}羰基）六氢-1-吡嗪基]和[（4 [ 氨基-4-（苄氧基）-5-甲氧基苯甲酰基]氨基苯基）磺酰基] -4-苯甲胺; X-H（或）吡嗪-2-羰基。 本发明还提供了制备通式（8）的新型邻氨基苯甲酸衍生物的方法，其可用作潜在的抗癌剂。

    Bis-2-difluoro-pyrrolo[2,1-C][1,4]benzodiazepine dimers
    68.
    发明授权
    Bis-2-difluoro-pyrrolo[2,1-C][1,4]benzodiazepine dimers 有权
    双-2-氟 - 吡咯并[2,1-C] [1,4]苯并二氮杂二聚体

    公开(公告)号：US07476664B2

    公开(公告)日：2009-01-13

    申请号：US11715592

    申请日：2007-03-07

    申请人： Ahmed Kamal ,  Depatla Rajasekhar Reddy ,  Rajendar Rajendar

    发明人： Ahmed Kamal ,  Depatla Rajasekhar Reddy ,  Rajendar Rajendar

    IPC分类号： C07D405/14 ,  A61K31/551 ,  A61P25/06

    CPC分类号： C07D519/00

    摘要： The present invention provides a novel bis 2-difluoro pyrrolo[2,1-c][1,4]benzodiazepine of formula VII wherein, n is 3 to 10. novel bis 2-difluoro pyrrolo[2,1-c][1,4]benzodiazepine of formula VII exhibits biding affinity with calf thymus (CT) DNA at a molar ratio of 1:5 in aqueous sodium phosphate buffer at pH of about 7.00. The present invention further provides a process for the preparation of novel bis 2-difluoro pyrrolo[2,1-c][1,4]benzodiazepine of formula VII.

    摘要翻译： 本发明提供式VII的新型双2-二氟吡咯并[2,1-c] [1,4]苯并二氮杂其中n为3至10.新型双2-二氟吡咯并[2,1-c] [1 ，4]苯并二氮杂与大牛胸腺（CT）DNA以1:5的摩尔比在pH7.00左右的磷酸钠缓冲液中显示出亲和力。 本发明还提供了制备式Ⅶ的新的双二氟吡咯并[2,1-c] [1,4]苯并二氮杂的方法。

    Podophyllotoxin derivatives as antitumor agents
    70.
    发明申请
    Podophyllotoxin derivatives as antitumor agents 审中-公开
    鬼臼毒素衍生物作为抗肿瘤剂

    公开(公告)号：US20070066837A1

    公开(公告)日：2007-03-22

    申请号：US10545838

    申请日：2004-02-13

    申请人： Ahmed Kamal ,  Mohammed Arifuddin ,  Banala Kumar ,  Sunanda Dastidar

    发明人： Ahmed Kamal ,  Mohammed Arifuddin ,  Banala Kumar ,  Sunanda Dastidar

    IPC分类号： C07D493/02

    CPC分类号： C07D493/04

    摘要： This invention relates to podophyllotoxin derivatives, more particularly to 4β-amino and 4β-amido derivatives of podophyllotoxin and 4′-O-demethylepipodophyllotoxin, which are useful for the treatment of tumors. Processes for the preparation of the compounds disclosed herein, pharmaceutical compositions containing these compounds, and methods for treating tumors are provided. The invention further relates to stereoselective compounds of podophyllotoxin and 4′-O-demethylepipodophyllotoxin derivatives.

    摘要翻译： 本发明涉及鬼臼毒素衍生物，更具体地涉及鬼臼毒素和4'-O-脱甲基表鬼臼脂素的4β-氨基和4beta-酰氨基衍生物，其可用于治疗肿瘤。 提供了本文公开的化合物的制备方法，含有这些化合物的药物组合物，以及治疗肿瘤的方法。 本发明还涉及鬼臼毒素和4'-O-脱甲基表鬼臼毒素衍生物的立体选择性化合物。