公开(公告)号：US5683667A

公开(公告)日：1997-11-04

申请号：US570237

申请日：1995-12-11

申请人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

发明人： Mark Fulmer ,  Brent R. Constantz ,  Ira C. Ison ,  Bryan M. Barr

IPC分类号： A61L24/00 ,  A61F2/00 ,  A61L24/02 ,  A61L27/12 ,  C01B25/32 ,  C04B12/02 ,  C04B28/34

CPC分类号： C01B25/32 ,  A61L24/02 ,  A61L27/12 ,  C01B25/321 ,  C04B12/02 ,  C04B12/025 ,  C04B28/34 ,  C04B28/344 ,  C04B28/346 ,  A61F2310/00293 ,  C04B2111/00836

摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.

摘要翻译： 提供了制备室温稳定的纯相α-C3P产物及其衍生物的方法。 在本发明方法中，磷酸三钙源被加热到足以将基本上所有的所述磷酸三钙源转化为基本相纯α-C3P产物的温度。 将所得产物的温度快速冷却至低于约700℃的温度，得到室温稳定的反应性α-C3P产物。 所得到的α-C3P产物可以被研磨以提供可用于制备磷酸钙水泥的α-C3P组合物。

公开(公告)号：US5178845A

公开(公告)日：1993-01-12

申请号：US724859

申请日：1991-07-02

申请人： Brent R. Constantz ,  Bryan Barr ,  Kevin McVicker

发明人： Brent R. Constantz ,  Bryan Barr ,  Kevin McVicker

IPC分类号： A61F2/00 ,  A61L24/00 ,  A61L24/02 ,  A61L27/24 ,  A61L27/46 ,  C01B25/32 ,  C01B25/455

CPC分类号： A61K6/033 ,  A61K6/04 ,  A61K6/0668 ,  A61K6/0675 ,  A61L24/0084 ,  A61L24/02 ,  A61L27/24 ,  A61L27/46 ,  C01B25/32 ,  C01B25/321 ,  C01B25/322 ,  C01B25/327 ,  C01B25/455 ,  A61F2310/00293

摘要： Novel compositions are provided for the production of hydroxyapatite, where a dry mixture is provided which combines a calcium source and an acidic phosphate source, particularly monocalcium phosphate monohydrate or orthophosphoric acid crystals. These two are combined, optionally with other ingredients, with mechanical mixing, resulting in partial reaction or intimate combination to produce a product which requires less water for formation of a desired viscosity, has enhanced mechanical properties and is physiologically acceptable.

摘要翻译： 提供了用于生产羟基磷灰石的新型组合物，其中提供了组合钙源和酸性磷酸盐源，特别是一水合磷酸钙或正磷酸晶体的干混合物。 这两种可以任选地与其它成分组合，机械混合，导致部分反应或紧密组合以产生需要较少水以形成所需粘度的产物，具有增强的机械性能并且在生理学上是可接受的。

公开(公告)号：US5034059A

公开(公告)日：1991-07-23

申请号：US312866

申请日：1989-02-17

申请人： Brent R. Constantz

发明人： Brent R. Constantz

IPC分类号： C30B7/14 ,  A61F2/00 ,  A61L27/12 ,  A61L27/32 ,  C01B25/32 ,  C30B29/14

CPC分类号： A61L27/32 ,  A61L27/12 ,  C01B25/325 ,  C01B25/327 ,  A61F2310/00293 ,  A61F2310/00796 ,  Y10S128/08

摘要： Octacalcium phosphate and hydroxyapatite are provided, where octacalcium phosphate is produced as novel single crystals and organized polycrystalline structures that are non-dense. The crystals serve as fibers, which find application in a wide variety of applications as well as coatings of prosthetic devices or other materials which may have physiological application.

公开(公告)号：US09833274B2

公开(公告)日：2017-12-05

申请号：US13434669

申请日：2012-03-29

申请人： Duran Yetkinler ,  David Delaney ,  Brent R. Constantz

发明人： Duran Yetkinler ,  David Delaney ,  Brent R. Constantz

IPC分类号： A61B17/88 ,  A61K33/42 ,  A61F2/46

CPC分类号： A61B17/8822 ,  A61F2002/4602 ,  A61F2002/4683 ,  A61K33/42

摘要： Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the cement, in preparation of the target site, in delivery of the cement to the target site, and/or following delivery of the cement to the target site. Also provided are devices, systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.

公开(公告)号：US08906156B2

公开(公告)日：2014-12-09

申请号：US13560246

申请日：2012-07-27

申请人： Brent R. Constantz ,  Paulo J. M. Monteiro ,  Kyle Self ,  Irvin Chen

发明人： Brent R. Constantz ,  Paulo J. M. Monteiro ,  Kyle Self ,  Irvin Chen

IPC分类号： C04B7/00 ,  C04B24/14 ,  C04B14/00 ,  C09C1/02 ,  C04B11/00 ,  C04B28/02

CPC分类号： C04B16/0641 ,  C04B11/00 ,  C04B14/28 ,  C04B16/0633 ,  C04B28/02 ,  Y02W30/97 ,  Y10S264/43 ,  C04B14/34 ,  C04B14/386 ,  C04B14/42 ,  C04B16/06 ,  C04B18/248 ,  C04B18/26 ,  C04B24/26 ,  C04B32/02

摘要： Provided are compositions, methods and systems including cementitious compositions and reinforcing materials wherein the cementitious composition comprises a metastable component.

摘要翻译： 提供了包括水泥组合物和增强材料的组合物，方法和系统，其中水泥组合物包含亚稳组分。

公开(公告)号：US08500683B2

公开(公告)日：2013-08-06

申请号：US11269864

申请日：2005-11-07

申请人： Brent R. Constantz ,  Peter K. Johansson ,  Erin McGurk

发明人： Brent R. Constantz ,  Peter K. Johansson ,  Erin McGurk

IPC分类号： A61M37/00

CPC分类号： A61M25/1011 ,  A61M25/0026 ,  A61M29/02 ,  A61M2025/0004 ,  A61M2025/1052 ,  A61M2025/1095

摘要： Catheter systems and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter systems include at least an aspiration catheter and at least one of a total occlusion insert catheter and a partial occlusion insert catheter, where the insert catheters are capable of being slidably moved in the lumen of the aspiration catheter. In practicing the subject methods, a surface of the vascular occlusion is flushed with an acidic dissolution fluid using the subject catheter systems for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter systems and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.

公开(公告)号：US08470275B2

公开(公告)日：2013-06-25

申请号：US12838794

申请日：2010-07-19

申请人： Brent R. Constantz ,  Andrew Youngs ,  Terence C. Holland

发明人： Brent R. Constantz ,  Andrew Youngs ,  Terence C. Holland

IPC分类号： C01B31/24 ,  B01D21/00

CPC分类号： C04B7/367 ,  C01B32/60 ,  C04B7/02 ,  C04B2103/0086 ,  Y02P40/18

摘要： Reduced-carbon footprint concrete compositions, and methods for making and using the same, are provided. Aspects of the reduced-carbon footprint concrete compositions include CO2-sequestering carbonate compounds, which may be present in the hydraulic cement and/or aggregate components of the concrete. The reduced-carbon footprint concrete compositions find use in a variety of applications, including use in a variety of building materials and building applications.

摘要翻译： 提供了减少碳足迹的混凝土组合物，以及制造和使用它们的方法。 减碳碳足迹混凝土组合物的方面包括CO 2截留的碳酸盐化合物，其可以存在于混凝土的水硬性水泥和/或骨料组分中。 减碳碳足迹混凝土组合物可用于各种应用，包括用于各种建筑材料和建筑应用中。

公开(公告)号：US20120165822A1

公开(公告)日：2012-06-28

申请号：US13347524

申请日：2012-01-10

申请人： Duran YETKINLER ,  David Delaney ,  Brent R. Constantz

发明人： Duran YETKINLER ,  David Delaney ,  Brent R. Constantz

IPC分类号： A61B17/88 ,  A61F2/28

CPC分类号： A61B17/8822 ,  A61F2002/4683 ,  A61K33/42

摘要： Methods of employing bone defect filling, e.g., orthopedic cements, in conjunction with hard tissue securing devices, e.g., screws, plates or rods, are provided. A feature of the subject methods is that the cement is introduced to a target bone site through a passageway of the securing device while a vibratory force is applied to the securing device. Also provided are systems and kits that find use in practicing the subject methods. The subject methods, devices and systems find use in a variety of different applications.

摘要翻译： 提供了使用骨缺损填充（例如矫形水泥）与硬组织固定装置（例如螺钉，板或杆）结合的方法。 本发明方法的特征在于，当将固定装置施加振动力时，通过固定装置的通道将水泥引入目标骨骼部位。 还提供了用于实践主题方法的系统和工具包。 主题方法，设备和系统可用于各种不同的应用。

公开(公告)号：US20120145047A1

公开(公告)日：2012-06-14

申请号：US13350199

申请日：2012-01-13

申请人： Brent R. Constantz ,  Kasra Farsad ,  Chris Camire ,  Joshua Patterson ,  Miguel Fernandez ,  Karin Yaccato ,  Ryan Thatcher ,  John Stagnaro ,  Irvin Chen ,  Sidney Omelon ,  Keith Hodson ,  Laurence Clodic ,  Katharine Geramita ,  Terence C. Holland

发明人： Brent R. Constantz ,  Kasra Farsad ,  Chris Camire ,  Joshua Patterson ,  Miguel Fernandez ,  Karin Yaccato ,  Ryan Thatcher ,  John Stagnaro ,  Irvin Chen ,  Sidney Omelon ,  Keith Hodson ,  Laurence Clodic ,  Katharine Geramita ,  Terence C. Holland

IPC分类号： C04B14/28 ,  C04B28/04

CPC分类号： C04B28/04 ,  B01D53/62 ,  B01D2251/404 ,  B01D2257/504 ,  B01D2258/0233 ,  C04B14/28 ,  C04B28/02 ,  Y02C10/00 ,  Y02C10/04 ,  Y10S264/43

摘要： Provided herein are compositions and methods including hydraulic cement, supplementary cementitious material, and/or self-cementing material. Methods for making the compositions and using the compositions are provided.

公开(公告)号：US20110132234A1

公开(公告)日：2011-06-09

申请号：US12777075

申请日：2010-05-10

申请人： Brent R. Constantz ,  Cecily Ryan ,  Laurence Clodic

发明人： Brent R. Constantz ,  Cecily Ryan ,  Laurence Clodic

IPC分类号： C04B7/02

CPC分类号： C04B28/04 ,  C04B14/26 ,  Y02W10/33 ,  Y02W10/37 ,  Y10T428/2982

摘要： Hydraulic cement compositions that include a carbonate compound composition, e.g., a salt-water derived carbonate compound composition containing crystalline and/or amorphous carbonate compounds, are provided. Also provided are methods of making and using the hydraulic cements, as well as settable compositions, such as concretes and mortars, prepared therefrom. The cements and compositions produced therefrom find use in a variety of applications, including use in a variety of building materials and building applications.

摘要翻译： 提供了包含碳酸盐化合物组合物的液压水泥组合物，例如含有结晶和/或无定形碳酸酯化合物的盐水衍生的碳酸盐化合物组合物。 还提供了制备和使用水硬性水泥的方法，以及由其制备的可固化组合物，例如混凝土和砂浆。 由此产生的水泥和组合物可用于各种应用，包括用于各种建筑材料和建筑应用中。