公开(公告)号：US4701466A

公开(公告)日：1987-10-20

申请号：US851114

申请日：1986-04-10

申请人： Thomas Purcell ,  Lydia Zard

发明人： Thomas Purcell ,  Lydia Zard

IPC分类号： A61K31/335 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  C07D313/12

CPC分类号： C07D313/12

摘要： Compounds of general formula ##STR1## in which R.sub.1, taken separately, denotes a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, andR.sub.2, taken separately, denotes a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or a phenylthio or phenylsulphonyl group, or alternativelyR.sub.1 and R.sub.2 together form an ethano bridge or, together with the two carbon atoms 8 and 9, form a fused benzene ring,R.sub.3 denotes a hydrogen atom or a methyl group andR.sub.4 denotes a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or a cation of a base which is acceptable in pharmacology, the group CH(R.sub.3)COOR.sub.4 being at position 2 or 3. have uses in treatment of inflammation, pain and undesirable platelet aggregation.

摘要翻译： 通式“IMAGE”的化合物，其中分别表示氢原子或C1-C4烷基的R1和分别表示的R2表示氢原子，C1-C4烷基或苯硫基或苯基磺酰基， 或者R1和R2一起形成乙烷桥，或者与两个碳原子8和9一起形成稠合苯环，R3表示氢原子或甲基，R4表示氢原子，C1-C4烷基 或药理学上可接受的碱的阳离子，CH（R3）COOR4基团在位置2或3上具有用于治疗炎症，疼痛和不期望的血小板聚集的用途。