公开(公告)号：US20190270784A1

公开(公告)日：2019-09-05

申请号：US16305686

申请日：2016-04-22

Applicant: Immatics Biotechnologies GmbH

Inventor： Andrea MAHR ,  Toni WEINSCHENK ,  Oliver SCHOOR ,  Jens FRITSCHE ,  Harpreet SINGH ,  Claudia WAGNER ,  Julia LEIBOLD ,  Colette SONG

IPC: C07K14/47 ,  A61K39/00 ,  C07K14/74 ,  C12N5/0783 ,  A61K35/17 ,  C07K16/30 ,  C07K16/28 ,  A61P35/00 ,  G16B20/20 ,  G01N33/574 ,  C12Q1/6886 ,  C07K14/725

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20170101473A1

公开(公告)日：2017-04-13

申请号：US15288145

申请日：2016-10-07

Applicant: immatics biotechnologies GmbH

Inventor： Andrea MAHR ,  Toni WEINSCHENK ,  Dominik MAURER ,  Claudia WAGNER ,  Felix HARTLEPP ,  Alexandra KRAUS

IPC: C07K16/28 ,  G01N33/68

CPC classification number: C07K16/2833 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/732 ,  G01N33/53 ,  G01N33/6854 ,  G01N2500/04

Abstract: The present invention relates to antibodies or fragments thereof binding to human WT1/HLA. In particular, the present invention relates to antibodies or fragments thereof that have combined improved and/or beneficial properties, and are therefore suited for clinical development.