公开(公告)号：US07491713B2

公开(公告)日：2009-02-17

申请号：US10587121

申请日：2005-01-25

申请人： Christopher S. Burgey ,  Daniel V. Paone ,  Anthony W Shaw ,  Craig A. Stump ,  Theresa M. Williams

发明人： Christopher S. Burgey ,  Daniel V. Paone ,  Anthony W Shaw ,  Craig A. Stump ,  Theresa M. Williams

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/06

CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： Compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, D, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, pharmaceutical compositions comprising these compounds, use of these compounds and compositions to prevent or treat diseases involving CGRP.

摘要翻译： 式I：和式II化合物（其中变量R1，R2，R3，R4，A，B，D，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂 并且可用于治疗或预防涉及CGRP的疾病，包含这些化合物的药物组合物，这些化合物和组合物的用途，以预防或治疗涉及CGRP的疾病。

公开(公告)号：US06534506B2

公开(公告)日：2003-03-18

申请号：US09828259

申请日：2001-04-06

申请人： Diem N. Nguyen ,  Craig A. Stump ,  Theresa M. Williams

发明人： Diem N. Nguyen ,  Craig A. Stump ,  Theresa M. Williams

IPC分类号： C07D49822

CPC分类号： C07D498/22 ,  C07D513/22

摘要： The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.