公开(公告)号：US4026894A

公开(公告)日：1977-05-31

申请号：US621980

申请日：1975-10-14

申请人： Martin Winn ,  Jaroslav Kyncl ,  Daniel Ambrose Dunnigan ,  Peter Hadley Jones

发明人： Martin Winn ,  Jaroslav Kyncl ,  Daniel Ambrose Dunnigan ,  Peter Hadley Jones

IPC分类号： C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D239/84

CPC分类号： C07D309/08

摘要： Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyquinazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

摘要翻译： 描述了选自2 [4（四氢-2-呋喃基） - 哌嗪基] -4-氨基-6,7-二甲氧基喹唑啉和2- [4（四氢吡喃-2-羰基） - 哌嗪基] -4的抗高血压药 - 氨基-6,7-二甲氧基喹唑啉及其药学上可接受的酸加成盐。 这些化合物是高度水溶性的，并且可以以时间释放形式以及肠胃外给药，包括静脉内给药。

公开(公告)号：USRE29196E

公开(公告)日：1977-04-26

申请号：US699831

申请日：1976-06-25

申请人： Martin Winn

发明人： Martin Winn

IPC分类号： C07C37/055 ,  C07C39/367 ,  C07C43/205 ,  C07D491/04

CPC分类号： C07D491/04 ,  C07C37/055 ,  C07C43/2055

摘要： Alkylphenyl benzopyranopyridines represented by the formula ##STR1## where R.sub.1 is hydrogen, loweralkyl, loweralkanoyl, cycloalkylloweralkyl, cycloalkylloweralkanoyl, loweralkenyl, loweralkynyl, haloloweralkenyl, phenylloweralkyl, phenylloweralkenyl or phenylloweralkynyl; R.sub.2 is loweralkyl; R.sub.3 is hydrogen; Y is a straight or branched chain alkylene group having from one to ten carbon atoms; and each R.sub.4 and R.sub.5 and R.sub.6 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl; and the pharmaceutically acceptable salts thereof.

公开(公告)号：US3947462A

公开(公告)日：1976-03-30

申请号：US472243

申请日：1974-05-22

申请人： David Lloyd Arendsen ,  Martin Winn

发明人： David Lloyd Arendsen ,  Martin Winn

IPC分类号： C07C37/055 ,  C07D311/60

CPC分类号： C07C37/055 ,  Y10S514/96

摘要： 2,4,7-Substituted 5-hydroxy benzopyrans and dihydrobenzopyrans and their esters represented by the formulae ##SPC1##Wherein each R.sub.1 is loweralkyl, and R.sub.2 is hydrogen, loweralkanoyl or ##SPC2##With Y being a straight or branched chain alkylene group having from 1-8 carbon atoms; a is an integer from 1-4; b is an integer from 1-4; X is CH.sub.2, O, S, or NR.sub.5 with R.sub.5 being hydrogen or loweralkyl, with the limitation that when X is O, S, or NR.sub.5, the sum of a and b is 3 or 4 and R.sub.4 is hydrogen or loweralkyl; and R.sub.3 is ##SPC3##With Y' being a straight or branched chain alkylene group having from 1-10 carbon atoms; and each R.sub.7, R.sub.8 and R.sub.9 are the same or different members of the group consisting of hydrogen, halo, trifluoromethyl or loweralkyl and the pharmaceutically acceptable salts thereof.

摘要翻译： 2,4,7-取代的5-羟基苯并吡喃和二氢苯并吡喃及其由下式表示的酯其中R 1为低级烷基，R 2为氢，低级烷酰基或Y Y为具有1-8个碳原子的直链或支链亚烷基 ; a是1-4的整数; b是1-4的整数; X为CH 2，O，S或NR 5，其中R 5为氢或低级烷基，限制在X为O，S或NR 5时，a和b之和为3或4，R4为氢或低级烷基; 并且R 3为Y Y'为具有1-10个碳原子的直链或支链亚烷基; 并且每个R 7，R 8和R 9是由氢，卤素，三氟甲基或低级烷基组成的组的相同或不同的成员及其药学上可接受的盐。