摘要:
Symmetrical bis-amidine derivatives of mitomycin C may be converted to unsymmetrical bis-amidine analogs by reaction with secondary amines. The compounds are active anti-tumor agents in experimental animal tumors.
摘要:
A new chemical synthesis of the pyrrolobenzodiazepine antibiotics BBM-2040A and B is disclosed. The disclosed total synthesis uses readily available starting materials and provides a useful alternative to the microbiological procedure previously used to prepare these antibiotics.
摘要:
Novel mono-, di- and triacylated derivatives of scirpentriol are provided for use as antitumor agents. Also provided are methods for the production of such derivatives.