公开(公告)号：US07745422B2

公开(公告)日：2010-06-29

申请号：US12103551

申请日：2008-04-15

申请人： John M. Sanders ,  Yongcheng Song ,  Julian M. W. Chan ,  Eric Oldfield ,  Yonghui Zhang

发明人： John M. Sanders ,  Yongcheng Song ,  Julian M. W. Chan ,  Eric Oldfield ,  Yonghui Zhang

IPC分类号： A61K31/675 ,  C07F9/38

CPC分类号： C07F9/3873 ,  C07F9/58 ,  C07F9/60 ,  C07F9/62 ,  C07F9/6506 ,  C07F9/65583

摘要： Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.

摘要翻译： 公开了双膦酸酯化合物及其制备和应用的相关方法，包括吡啶鎓-1-基，喹啉鎓-1-基和相关化合物。 化合物的活性在诸如利什曼原虫主要法呢基二磷酸合成酶（FPPS）抑制，盘基网柄菌生长抑制，人γδT细胞活化和骨吸收等功能测定的上下文中公开。 公开了二膦酸化合物在寄生虫感染（例如针对锥虫）的情况下的适用性。 公开了关于治疗一种或多种病症如骨吸收障碍，癌症，骨痛，感染性疾病和免疫治疗的本发明的其它潜在应用。

公开(公告)号：US20100113415A1

公开(公告)日：2010-05-06

申请号：US12473773

申请日：2009-05-28

申请人： Hemaka A. Rajapakse ,  Keith P. Moore ,  Philippe G. Nantermet ,  John M. Sanders ,  Sophie Parmentier-Batteur ,  Robert J. Mark

发明人： Hemaka A. Rajapakse ,  Keith P. Moore ,  Philippe G. Nantermet ,  John M. Sanders ,  Sophie Parmentier-Batteur ,  Robert J. Mark

IPC分类号： A61K31/4745 ,  C07D471/04 ,  C07D413/14 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/397 ,  A61P25/00

CPC分类号： C07D471/04 ,  C07D471/14

摘要： The present invention is directed to compounds of generic formula (I) which are inhibitors of ephrin A4. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases regulated by the EphA4 RTK signaling, such as neurological and neurodegenerative disorders and cancer.

公开(公告)号：USD571665S1

公开(公告)日：2008-06-24

申请号：US29285908

申请日：2007-04-17

申请人： John M. Sanders

设计人： John M. Sanders

公开(公告)号：US07358361B2

公开(公告)日：2008-04-15

申请号：US11245612

申请日：2005-10-07

申请人： John M. Sanders ,  Yongcheng Song ,  Julian M. W. Chan ,  Eric Oldfield ,  Yonghui Zhang

发明人： John M. Sanders ,  Yongcheng Song ,  Julian M. W. Chan ,  Eric Oldfield ,  Yonghui Zhang

IPC分类号： C07F9/38 ,  C07F9/28

CPC分类号： C07F9/3873 ,  C07F9/58 ,  C07F9/60 ,  C07F9/62 ,  C07F9/6506 ,  C07F9/65583

摘要： Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.

摘要翻译： 公开了双膦酸酯化合物及其制备和应用的相关方法，包括吡啶鎓-1-基，喹啉鎓-1-基和相关化合物。 化合物的活性在诸如利什曼原虫主要法呢基二磷酸合成酶（FPPS）抑制，盘基网柄菌生长抑制，人γδT细胞活化和骨吸收等功能测定的上下文中公开。 公开了二膦酸化合物在寄生虫感染（例如针对锥虫）的情况下的适用性。 公开了关于治疗一种或多种病症如骨吸收障碍，癌症，骨痛，感染性疾病和免疫治疗的本发明的其它潜在应用。

公开(公告)号：USD434478S

公开(公告)日：2000-11-28

申请号：US81424

申请日：1997-01-02

申请人： John M. Sanders

设计人： John M. Sanders

公开(公告)号：US5824989A

公开(公告)日：1998-10-20

申请号：US933780

申请日：1997-09-19

申请人： John M. Sanders ,  Patrick M. Ryan

发明人： John M. Sanders ,  Patrick M. Ryan

IPC分类号： B23K10/00

CPC分类号： B23K10/02 ,  B23K37/0229 ,  B23K37/0241 ,  B23K37/0247 ,  B23K37/0276 ,  B23K37/0282 ,  B23K2201/06

摘要： An improved plasma arc welding arm method and apparatus for keyhole welding rotating workpieces has an arcuate gear track supporting a corresponding arcuate geared cart bearing a plasma arc welding torch prevents voids in keyhole weld starts and finishes. The gear track is mounted on a manipulator arm for positioning the welding torch in proximity to a rotating workpiece to be welded. The torch may be rotated on the cart and gear track in the same direction and at the same rotational speed as the workpiece.

公开(公告)号：US5773786A

公开(公告)日：1998-06-30

申请号：US932596

申请日：1997-09-17

申请人： John M. Sanders ,  John M. Lehmann ,  Patrick M. Ryan

发明人： John M. Sanders ,  John M. Lehmann ,  Patrick M. Ryan

IPC分类号： B23K10/02 ,  B23K33/00 ,  B23K10/00

CPC分类号： B23K10/02 ,  B23K33/00

摘要： A shim for improving plasma arc weld quality has ends tapered at about 25.degree. and notches at each end roughly centered over the corner between the tapered ends and main body of the shim. The improved shim allows lower starting plasma arc heat input and reduces the occurrence of sagging, or overpenetration, of the weld.

公开(公告)号：US5624067A

公开(公告)日：1997-04-29

申请号：US533896

申请日：1995-09-26

申请人： Dennis D. Harwig ,  John M. Sanders ,  Stephen W. Manring

发明人： Dennis D. Harwig ,  John M. Sanders ,  Stephen W. Manring

IPC分类号： B23K37/06

CPC分类号： B23K37/06 ,  B23K2201/06

摘要： A method and apparatus for groove weld joining pipe sections along a rotating preform having a circumferential groove thereon along which the preformed adjoining pipe sections are located to form a weld in the joining area and a underbead in the groove of the preform to thus weld together the pipe sections.

摘要翻译： 一种用于沿着具有周向槽的旋转预制件的槽部焊接接合管部分的方法和装置，预成型的邻接管段沿着该圆周槽定位以在接合区域中形成焊缝，并且在预成型件的凹槽中形成焊缝，从而焊接在一起 管段。

公开(公告)号：US5183989A

公开(公告)日：1993-02-02

申请号：US716195

申请日：1991-06-17

申请人： John M. Sanders ,  Dennis D. Harwig

发明人： John M. Sanders ,  Dennis D. Harwig

IPC分类号： B23K10/02 ,  B23K15/00 ,  B23K26/24 ,  B23K33/00

CPC分类号： B23K10/02 ,  B23K15/0053 ,  B23K26/24 ,  B23K33/00

摘要： An improved high energy density welding method for reducing input keyhole welding prepares the weld joint (8) between two edges (10, 14) of at least one member by separating the edges (10, 14) of the member (12, 16) with a controllable gap (22) by a projecting portion (24) selectively positioned on one edge (10, 14) of the member (12, 16). The projecting portion (24) closely abuts the other edge of the member for maintaining the controlled distance (d) of the controllable gap (22) to enhance the welding method.

摘要翻译： 用于减小输入键孔焊接的改进的高能量密度焊接方法通过将构件（12,16）的边缘（10,14）分离与至少一个构件的两个边缘（10,14）之间来准备焊接接头（8） 通过选择性地定位在构件（12,16）的一个边缘（10,14）上的突出部分（24）的可控间隙（22）。 突出部分24紧密地抵靠在构件的另一个边缘上，以保持可控间隙（22）的受控距离（d），以增强焊接方法。