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公开(公告)号:US07067280B2
公开(公告)日:2006-06-27
申请号:US10373802
申请日:2003-02-27
IPC分类号: C12N15/00
CPC分类号: G01N33/6887 , A61K38/00 , C07K14/78 , C07K16/40 , C12N9/2442 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Y302/01014 , G01N2333/924
摘要: Nucleic acid sequences for HC gp-39L are provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.
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公开(公告)号:US20060083752A1
公开(公告)日:2006-04-20
申请号:US11166905
申请日:2005-06-23
申请人: Michael Black , Martin Burnham , Jason Fedon , John Hodgson , David Knowles , Michael Lonetto , Richard Nicholas , Leslie Palmer , Julie Pratt , Raymond Reichard , Martin Rosenberg , Christopher Traini , Judith Ward , Richard Warren
发明人: Michael Black , Martin Burnham , Jason Fedon , John Hodgson , David Knowles , Michael Lonetto , Richard Nicholas , Leslie Palmer , Julie Pratt , Raymond Reichard , Martin Rosenberg , Christopher Traini , Judith Ward , Richard Warren
IPC分类号: A61K39/02 , C07H21/04 , C12N15/74 , C07K14/195 , C12N1/21
CPC分类号: C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译: 本发明涉及新鉴定的葡萄球菌多核苷酸,由这种多核苷酸编码的多肽,这种多核苷酸和多肽的用途,以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
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公开(公告)号:US5811535A
公开(公告)日:1998-09-22
申请号:US694915
申请日:1996-08-09
IPC分类号: G01N33/50 , A61K31/711 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/02 , A61P9/10 , A61P13/12 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/51 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/566 , C07H21/04
CPC分类号: C07K14/51 , A01K2217/05 , A61K38/00 , A61K48/00
摘要: HC gp39-L polypeptides and DNA (RNA) encoding such HC gp39-L and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HC gp39-L for the treatment of rheumatoid and osteoarthritis, osteoporosis, artherosclerosis, metastatic cancers, periodontia, chronic renal diseases, etc. Antagonists against such HC gp39-L and their use as a therapeutic to treat rheumatoid and osteoarthritis, osteoporosis, artherosclerosis, metastatic cancers, periodontia, chronic renal diseases, etc. are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HC gp39-L and for detecting altered levels of the polypeptide in a host.
摘要翻译: 公开了HC gp39-L多肽和编码这种HC gp39-L的DNA(RNA)和通过重组技术产生这种多肽的方法。 还公开了利用这种HC gp39-L治疗类风湿和骨关节炎,骨质疏松症,动脉粥样硬化,转移性癌症,牙周炎,慢性肾脏疾病等的方法。对这种HC gp39-L的拮抗剂及其用作治疗类风湿病的治疗剂 骨关节炎,骨质疏松症,动脉粥样硬化,转移性癌症,牙周炎,慢性肾脏疾病等。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HC gp39-L的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。
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公开(公告)号:US5498529A
公开(公告)日:1996-03-12
申请号:US162506
申请日:1993-12-03
申请人: Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
发明人: Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
CPC分类号: C07K14/811 , C07K14/36 , C12N15/76 , C07K2319/02
摘要: This invention relates to a process for producing a heterologous polypeptide in Streptomyces which involves transforming a Streptomyces organism with a recombinant DNA molecule comprising an LEP-10 of LTl sequence selected from the group consisting of a sequence encoding a gene expression unit, a promoter sequence or an export control encoding sequence each operatively linked to a heterologous coding sequence and then culturing the transformed Streptomyces such that the heterologous polypeptide is expressed.
摘要翻译: 本发明涉及在链霉菌中生产异源多肽的方法,其涉及用包含LT1序列的LEP-10的重组DNA分子转化链霉菌生物体,所述重组DNA分子选自编码基因表达单位的序列,启动子序列或 一个出口控制编码序列,每一个可操作地连接到异源编码序列,然后培养转化的链霉菌,使得表达异源多肽。
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公开(公告)号:US5279939A
公开(公告)日:1994-01-18
申请号:US894167
申请日:1992-06-03
申请人: Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
发明人: Thomas R. Berka , James A. Fornwald , Joselina G. Gorniak , Martin Rosenberg , James E. Strickler , Dean P. Taylor
IPC分类号: C07K14/36 , C07K14/81 , C12N15/76 , C12Q1/68 , C07K13/00 , C07K15/04 , C12N15/00 , C12N15/10 , C12N15/11 , C12N15/31
CPC分类号: C07K14/811 , C07K14/36 , C12N15/76 , C07K2319/02
摘要: This invention relates to novel protein protease inhibitors as well as DNAs encoding same and vectors and transformed host cells useful for the recombinant production of the inhibitors.
摘要翻译: 本发明涉及新的蛋白质蛋白酶抑制剂以及编码它们的DNA,以及用于重组产生抑制剂的载体和转化的宿主细胞。
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