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61.发明申请公开(公告)号：US20110174613A1
公开(公告)日：2011-07-21
申请号：US12930627
申请日：2011-01-11
IPC分类号： G01N27/403
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.
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62.发明申请2-(Alkylcarbonyloxy)-1, 1-Difluoroethanesulfonic Acid Salt and Method for Producing the Same 有权2-（烷基羰氧基）-1,1-二氟乙磺酸盐及其制备方法公开(公告)号：US20110034721A1
公开(公告)日：2011-02-10
申请号：US12678250
申请日：2008-09-05
IPC分类号： C07C69/74
CPC分类号： C07C309/17 , C07C29/147 , C07C67/08 , C07C67/14 , C07C303/32 , C07C309/08 , C07C309/12 , C07C313/04 , C07C381/12 , C07C2602/42 , C07C2603/74 , G03F7/0045 , G03F7/0046 , C07C31/34 , C07C69/653 , C07C69/63 , C07C69/753
摘要： By using an organic base when a carboxylic acid bromodifluoroethyl ester is sulfinated by using a sulfinating agent, there is obtained 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfinic acid ammonium salt. By oxidizing the 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfinic acid ammonium salt, there is obtained 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfonic acid ammonium salt. By using the 2-(alkylcarbonyloxy)-1,1-difluoroethanesulfonic acid ammonium salt as a raw material and exchanging it into an onium salt directly or through saponification/esterification, there can be obtained a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid onium salt.
摘要翻译： 通过使用硫酸化剂将羧酸溴二氟乙酯磺化时，通过使用有机碱，得到2-（烷基羰氧基）-1,1-二氟乙烷亚磺酸铵盐。 通过氧化2-（烷基羰基氧基）-1,1-二氟乙烷亚磺酸铵盐，得到2-（烷基羰氧基）-1,1-二氟乙磺酸铵盐。 通过使用2-（烷基羰氧基）-1,1-二氟乙磺酸铵盐作为原料，直接或通过皂化/酯化将其交换为鎓盐，可以得到2-烷基羰基氧基-1,1-二氟乙磺酸 盐盐
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63.发明申请Processes for Production of 2-Bromo-2,2-Difluoroethanol and 2-(Alkylcarbonyloxy)-1,1-Difluoroethanesulfonic Acid Salt 有权制备2-溴-2,2-二氟乙醇和2-（烷基羰基氧基）-1,1-二氟乙磺酸盐的方法公开(公告)号：US20110015431A1
公开(公告)日：2011-01-20
申请号：US12678223
申请日：2008-09-05
IPC分类号： C07C67/16 , C07C309/08 , C07C309/10 , C07C29/143
CPC分类号： C07C309/17 , C07C29/147 , C07C67/08 , C07C67/14 , C07C303/32 , C07C309/08 , C07C309/12 , C07C313/04 , C07C381/12 , C07C2602/42 , C07C2603/74 , G03F7/0045 , G03F7/0046 , C07C31/34 , C07C69/653 , C07C69/63 , C07C69/753
摘要： Disclosed is a process for producing 2-bromo-2,2-difluoroethanol, which comprises reducing a bromodifluoroacetic acid derivative represented by the formula [1] by using an ate hydride complex as a reducing agent. 2-Bromo-2,2-difluoroethanol thus produced can be used as the starting material to carry out the esterification step, the sulfination step and the oxidation step in this order, thereby producing a 2-alkylcarbonyloxy-1,1-difluoroethanesulfonic acid salt, wherein A represents a substituted or unsubstituted linear, branched or cyclic alkoxy group having 1 to 20 carbon atoms, a substituted or unsubstituted aryloxy group having 6 to 15 carbon atoms, a heteroaryloxy group having 4 to 15 carbon atoms, or a halogen atom.
摘要翻译： 公开了一种2-溴-2,2-二氟乙醇的制备方法，其包括使用氢化物络合物作为还原剂还原式[1]表示的溴二氟乙酸衍生物。 可以使用如此制备的2-溴-2,2-二氟乙醇作为起始原料，依次进行酯化步骤，硫化步骤和氧化步骤，由此制备2-烷基羰基氧基-1,1-二氟乙磺酸盐 其中A表示取代或未取代的具有1至20个碳原子的直链，支链或环状烷氧基，取代或未取代的碳原子数6〜15的芳氧基，碳原子数4〜15的杂芳氧基或卤素原子。
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64.发明申请METHOD FOR MEASURING HEMATOCRIT VALUE OF BLOOD SAMPLE, METHOD FOR MEASURING CONCENTRATION OF ANALYTE IN BLOOD SAMPLE, SENSOR CHIP AND SENSOR UNIT 有权测量血液样本血液值的方法，测量血液样品分析仪浓度，传感器芯片和传感器单元的方法公开(公告)号：US20100243476A1
公开(公告)日：2010-09-30
申请号：US12377514
申请日：2007-10-17
申请人： Masaki Fujiwara , Shin Ikeda , Takahiro Nakaminami
发明人： Masaki Fujiwara , Shin Ikeda , Takahiro Nakaminami
CPC分类号： G01N27/3274 , G01N27/3272 , G01N27/413
摘要： Voltage is applied across a counter electrode and a working electrode, with which a blood sample is in contact, in such a state that an oxidant in a redox substance is not substantially in contact with a working electrode but is in contact with a counter electrode and a reductant is not substantially in contact with the counter electrode but is in contact with the working electrode, whereby the reductant and the oxidant are respectively oxidized and reduced to measure current produced upon the oxidation and reduction. According to the above constitution, while lowering the voltage applied across the working electrode and the counter electrode, the Hct value of the blood sample can be measured stably with a satisfactory detection sensitivity. This measurement can be carried out with a sensor chip comprising a working electrode (11), a counter electrode (12), and a blood sample holding part (14) having branch parts (18a, 18b). A first reagent (13) consisting essentially of an oxidant in a redox substance is disposed in contact with the surface of a counter electrode which faces the branch part (18b), and a second reagent (19) consisting essentially of a reductant is disposed in contact with the surface of a working electrode that faces the branch part (18a).
摘要翻译： 在氧化还原物质中的氧化剂基本上不与工作电极接触但与对电极接触的状态下，跨越对置电极和与血液样品接触的工作电极施加电压， 还原剂基本上不与对电极接触，而是与工作电极接触，由此还原剂和氧化剂分别被氧化和还原，以测量在氧化和还原时产生的电流。 根据上述结构，在降低施加在工作电极和对电极两端的电压的同时，能够以良好的检测灵敏度稳定地测定血液样品的Hct值。 该测量可以用包括工作电极（11），对电极（12）和具有分支部分（18a，18b）的血液样本保持部分（14）的传感器芯片进行。 基本上由氧化还原物质中的氧化剂组成的第一试剂（13）被设置成与面对分支部分（18b）的对电极的表面接触，并且基本上由还原剂组成的第二试剂（19）设置在 与面向分支部（18a）的工作电极的表面接触。
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公开(公告)号：US20100006432A1
公开(公告)日：2010-01-14
申请号：US12456199
申请日：2009-06-12
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
CPC分类号： C12Q1/003
摘要： In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration.
摘要翻译： 在用于测量液体样品中的特定物质的生物传感器中，分子中具有至少一个羧基的糖醇，金属盐，有机酸或有机酸盐的一种或组合，以及有机酸或有机酸盐，其具有 分子中的至少一个羧基和一个氨基被包含在设置在电极上的试剂层中，从而提供稳定性优异并且具有高传感器对基板的响应（灵敏度，线性）的高精度生物传感器 浓度。
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公开(公告)号：US20070007128A1
公开(公告)日：2007-01-11
申请号：US11519132
申请日：2006-09-12
CPC分类号： H01J37/321 , C23C14/165 , C23C14/3471
摘要： A silicon film forming apparatus includes a deposition chamber (10), a silicon sputter target (2) arranged in the chamber, a hydrogen gas supply circuit (102 or 102′) supplying a hydrogen gas into the chamber, and a high-frequency power applying device (antenna 1, 1′, power source PW and others) generating inductively coupled plasma by applying high-frequency power to the gas supplied into the deposition chamber (10). Chemical sputtering is effected on the target (2) by the plasma to form a silicon film on a substrate S. A silane gas may be used. A silane gas supply circuit (101) may be provided with a gas reservoir unit (GR). The silicon film can be formed inexpensively and fast at a relatively low temperature.
摘要翻译： 硅膜形成装置包括沉积室（10），布置在室中的硅溅射靶（2），将氢气供应到室中的氢气供应电路（102或102'）和高频功率 通过向供应到沉积室（10）的气体施加高频电力来产生电感耦合等离子体的施加装置（天线1,1'，电源PW等）。 通过等离子体在靶（2）上进行化学溅射，以在衬底S上形成硅膜。可以使用硅烷气体。 硅烷气体供给回路（101）也可以设置有气体储存部（GR）。 硅膜可以在相对较低的温度下廉价且快速地形成。
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公开(公告)号：US06911131B2
公开(公告)日：2005-06-28
申请号：US09979842
申请日：2001-03-28
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
IPC分类号： C12Q1/00 , G01N27/327 , G01N21/00
CPC分类号： C12Q1/003
摘要： In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration.
摘要翻译： 在用于测量液体样品中的特定物质的生物传感器中，分子中具有至少一个羧基的糖醇，金属盐，有机酸或有机酸盐的一种或组合，以及有机酸或有机酸盐，其具有 分子中的至少一个羧基和一个氨基被包含在设置在电极上的试剂层中，从而提供稳定性优异并且具有高传感器对基板的响应（灵敏度，线性）的高精度生物传感器 浓度。
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68.发明授权Biosensor, method of forming thin-film electrode, and method and apparatus for quantitative determination 有权生物传感器，薄膜电极的形成方法，定量测定方法和装置公开(公告)号：US06875327B1
公开(公告)日：2005-04-05
申请号：US09889243
申请日：2000-11-14
IPC分类号： C12Q1/00 , G01N27/327 , H05H1/00
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： The invention provides a biosensor comprising a support; a conductive layer composed of a electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.
摘要翻译： 本发明提供一种生物传感器，其包含支撑体; 由导电材料如贵金属（例如金或钯）和碳组成的导电层; 平行于和垂直于支撑体侧面的狭缝; 工作，计数器和检测电极; 覆盖支架上的工作电极，反电极和检测电极的间隔件; 在间隔件中形成矩形切口，形成试样供应路径; 样品供应路径的入口; 通过将含有酶的试剂施加到通过所述间隔件中的切口暴露的所述工作，反向和检测电极而形成的试剂层; 和间隔物上的盖子。 可以通过简单的方法形成生物传感器，并且不管试剂组成如何，在电极上提供均匀的试剂层。
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公开(公告)号：US06569571B2
公开(公告)日：2003-05-27
申请号：US09725872
申请日：2000-11-30
申请人： Yuji Nakagawa , Toshihiko Nishiyama , Masaki Fujiwara , Gaku Harada , Shinako Kaneko , Masato Kurosaki
发明人： Yuji Nakagawa , Toshihiko Nishiyama , Masaki Fujiwara , Gaku Harada , Shinako Kaneko , Masato Kurosaki
IPC分类号： H01M464
摘要： A secondary battery comprises a pair of collectors made of a valve action metal, a pair of electrodes comprising a sulfuric acid aqueous solution, a separator and an outer can. Each collector is covered with an oxide film of a thickness of 1.7-10 nm. The oxide film is formed in a range of from 30% by area or more to less than 100% by area relative to the surface area of the collector. Each collector has one electrode disposed thereon.
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公开(公告)号：US06309526B1
公开(公告)日：2001-10-30
申请号：US09384103
申请日：1999-08-26
IPC分类号： G01N2726
CPC分类号： G01N27/3272 , G01N33/525
摘要： A biosensor is fabricated by forming a metal film over the surface of a substrate through evaporation, sputtering or by gluing a metal foil, then splitting the metal film into three regions, and forming a reagent layer on an area of measuring electrode and two counter-electrodes for placing a liquid sample on by providing a cover disposed over the splitted metal film. As neither of the electrodes are formed through conventional printing technology, the electrodes can be formed without dispersion. As a result, a precision biosensor having excellent response characteristics is implemented.
摘要翻译： 通过蒸发，溅射或粘合金属箔在基板的表面上形成金属膜，然后将金属膜分割成三个区域，并在测量电极的区域上形成试剂层， 用于通过提供设置在分离的金属膜上的盖来放置液体样品的电极。 由于既不通过常规印刷技术形成电极，也可以不分散地形成电极。 结果，实现了具有优异的响应特性的精密生物传感器。
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