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公开(公告)号：US20050186248A1
公开(公告)日：2005-08-25
申请号：US11064916
申请日：2005-02-22
申请人： Syed Hossainy , Yiwen Tang , Andrew Tung , Stephen Pacetti
发明人： Syed Hossainy , Yiwen Tang , Andrew Tung , Stephen Pacetti
CPC分类号： A61F2/82 , A61F2250/0056 , A61F2250/0067 , A61L31/10 , Y10T428/13 , Y10T428/24942
摘要： A stent comprising a coating layer is disclosed. The coating layer has a hydrophobic component and a hydrophilic component, wherein a region of the coating layer on or about the outermost surface of the coating layer has a higher content or concentration of the hydrophilic component than the hydrophobic component.
摘要翻译： 公开了一种包括涂层的支架。 涂层具有疏水性成分和亲水性成分，其中涂层的最外表面上或周围的涂层的区域具有比疏水性成分更高的亲水性成分的含量或浓度。
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公开(公告)号：US08846070B2
公开(公告)日：2014-09-30
申请号：US12182066
申请日：2008-07-29
CPC分类号： A61L31/10 , A61L27/34 , A61L31/148 , A61L2420/06 , C08L67/04
摘要： A medical article is disclosed, comprising a biologically degradable AB block copolymer and a biologically degradable polymer that is capable, at equilibrium and at room temperature, of absorbing less than about 5 mass % water.
摘要翻译： 公开了一种医疗用品，其包含生物降解性AB嵌段共聚物和生物可降解聚合物，其能够在平衡和室温下吸收小于约5质量％的水。
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63.发明申请BIOLOGICALLY ABSORBABLE COATINGS FOR IMPLANTABLE DEVICES AND METHODS FOR FABRICATING THE SAME 有权用于可植入装置的生物吸收性涂料及其制造方法公开(公告)号：US20110117161A9
公开(公告)日：2011-05-19
申请号：US12115347
申请日：2008-05-05
申请人： Syed F.A. Hossainy , Eugene T. Michal , Yiwen Tang
发明人： Syed F.A. Hossainy , Eugene T. Michal , Yiwen Tang
IPC分类号： A61F2/06 , A61F2/00 , A61K31/436
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/114 , A61L2300/606 , C08L67/04 , C08L71/02
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising a biologically degradable, biologically erodable, and/or biologically resorbable ABA or AB block copolymer. A biologically active agent can be conjugated to the block copolymer.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含生物可降解，生物可侵蚀和/或生物可再吸收的ABA或AB嵌段共聚物。 生物活性剂可以与嵌段共聚物缀合。
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64.发明申请公开(公告)号：US20110033517A1
公开(公告)日：2011-02-10
申请号：US12909668
申请日：2010-10-21
申请人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
发明人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/10 , A61L2300/252 , A61L2300/606 , C08L75/04
摘要： A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
摘要翻译： 公开了一种分段聚氨酯和两亲无规或嵌段共聚物。 分段聚氨酯和两亲无规或嵌段共聚物可用于制造可植入医疗装置例如支架的涂层。
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公开(公告)号：US20110008529A1
公开(公告)日：2011-01-13
申请号：US12884106
申请日：2010-09-16
申请人： Syed F.A. Hossainy , Yiwen Tang , Manish Gada
发明人： Syed F.A. Hossainy , Yiwen Tang , Manish Gada
CPC分类号： A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2420/02 , B29C71/02 , C08L67/04
摘要： A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.
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66.发明授权公开(公告)号：US07776991B2
公开(公告)日：2010-08-17
申请号：US12488250
申请日：2009-06-19
申请人： Stephen D. Pacetti , Yiwen Tang
发明人： Stephen D. Pacetti , Yiwen Tang
CPC分类号： C08G63/181 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/416 , C08G2230/00 , C08L67/02
摘要： The disclosure contains a medical article comprising a polymer containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol and a polycarboxylic acid.
摘要翻译： 本公开包含医疗制品，其包含含聚酯的聚合物，以及任选的用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含含有多元醇和多元羧酸的反应的聚合产物的聚合物。
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公开(公告)号：US20090238854A1
公开(公告)日：2009-09-24
申请号：US12475296
申请日：2009-05-29
申请人： STEPHEN DIRK PACETTI , Yiwen Tang , Syed Hossainy
发明人： STEPHEN DIRK PACETTI , Yiwen Tang , Syed Hossainy
CPC分类号： A61K47/34 , A61K31/436 , A61L27/34 , A61L27/502 , A61L31/10 , A61L31/141 , C08K5/1575 , C08L67/04 , C09D167/00
摘要： A biocompatible plasticizer useful for forming a coating composition with a biocompatible polymer is provided. The coating composition may also include a biobeneficial polymer and/or a bioactive agent. The coating composition can form a coating on an implantable device. The implantable device can be used to treat or prevent a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译： 提供了可用于形成具有生物相容性聚合物的涂料组合物的生物相容性增塑剂。 涂料组合物还可以包括生物有益的聚合物和/或生物活性剂。 涂料组合物可以在可植入装置上形成涂层。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞 ，输尿管阻塞，肿瘤阻塞或其组合。
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68.发明授权公开(公告)号：US07569655B2
公开(公告)日：2009-08-04
申请号：US11726661
申请日：2007-03-21
申请人： Stephen D. Pacetti , Yiwen Tang
发明人： Stephen D. Pacetti , Yiwen Tang
IPC分类号： C08G63/00
CPC分类号： C08G63/181 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/114 , A61L2300/416 , C08G2230/00 , C08L67/02
摘要： Polymers containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol and a polycarboxylic acid.
摘要翻译： 公开了含有聚酯和任选的用于医疗制品的试剂的聚合物及其制造方法。 医疗制品通常包括具有涂层的可植入基底，并且该涂层含有包含含有多元醇和多元羧酸的反应的聚合产物的聚合物。
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公开(公告)号：US07563483B2
公开(公告)日：2009-07-21
申请号：US11064530
申请日：2005-02-22
CPC分类号： A61F2/82 , A61F2250/0056 , A61F2250/0067 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , Y10T428/24942
摘要： Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include hydrophilic and hydrophobic components. The methods provide for treatment of the coatings to cause enrichment a region close to, at or on the outer surface of the coating with the hydrophilic component.
摘要翻译： 公开了用于制造可植入医疗装置的涂层的方法。 涂层包括亲水和疏水组分。 该方法提供了处理涂层以使亲水组分在涂层的外表面附近或附近的区域富集。
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70.发明申请Polymer blends for drug delivery stent matrix with improved thermal stability 审中-公开用于药物递送支架基质的聚合物共混物具有改善的热稳定性公开(公告)号：US20090111787A1
公开(公告)日：2009-04-30
申请号：US11982168
申请日：2007-10-31
CPC分类号： A61L31/10 , A61L2420/02 , A61L2420/06 , C08L67/04 , C09D167/04 , C08L2666/18
摘要： Various embodiments of the present invention generally relate to a polymer blend composition used for coating a medical device that exhibits improved thermal stability. The invention also encompasses implantable medical devices coated the aforementioned coating.
摘要翻译： 本发明的各种实施方案一般涉及用于涂覆显示改善的热稳定性的医疗装置的聚合物共混物组合物。 本发明还包括涂覆上述涂层的可植入医疗装置。
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