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    Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability
    61.
    发明授权
    Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 有权
    抛光可植入医疗器械降低血栓形成并增加机械稳定性的方法

    公开(公告)号：US07329366B1

    公开(公告)日：2008-02-12

    申请号：US10871404

    申请日：2004-06-18

    申请人： David C. Gale ,  Syed F. A. Hossainy

    发明人： David C. Gale ,  Syed F. A. Hossainy

    IPC分类号： B44C1/22

    CPC分类号： A61L31/10 ,  A61F2/91 ,  A61F2210/0004 ,  Y10S623/901

    摘要： The present invention relates to a method of polishing an implantable medical device. The method may include positioning an implantable medical device on a support. At least a portion of a surface of the implantable medical device may include a polymer. A fluid may be contacted with at least a portion of the surface of the positioned implantable medical device. In an embodiment, the fluid may be capable of dissolving at least a portion of the polymer at or near the surface of the implantable medical device. The method may further include allowing the fluid to modify at least a portion of the surface of the positioned medical device. A majority of the contacted fluid may be removed from the surface of the implantable medical device. In certain embodiments, the modified portion of the surface may be substantially less thrombogenetic and substantially more mechanically stable than an unmodified surface.

    摘要翻译： 本发明涉及一种抛光可植入医疗器械的方法。 该方法可以包括将可植入医疗装置定位在支撑件上。 可植入医疗装置的表面的至少一部分可以包括聚合物。 流体可以与定位的可植入医疗装置的表面的至少一部分接触。 在一个实施方案中，流体可能能够将聚合物的至少一部分溶解在可植入医疗装置的表面处或附近。 该方法还可以包括允许流体修改定位的医疗装置的表面的至少一部分。 接触流体的大部分可以从可植入医疗装置的表面移除。 在某些实施方案中，表面的改性部分可以比未修饰的表面基本上更少的血栓形成和基本上更机械稳定的。

    Selective coating of medical devices
    62.
    发明授权
    Selective coating of medical devices 有权
    医疗器械的选择性涂层

    公开(公告)号：US07297159B2

    公开(公告)日：2007-11-20

    申请号：US10897244

    申请日：2004-07-21

    申请人： Syed F. A. Hossainy ,  Daryush Mirzaee

    发明人： Syed F. A. Hossainy ,  Daryush Mirzaee

    IPC分类号： A61F2/06

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/608

    摘要： Methods for coating different regions of an implantable device are disclosed. An embodiment of the method includes dipping a first portion of the implantable device into a first coating substance, and then centrifuging the implantable device to provide an even coating. Next, a second portion of the implantable device is dipped into a second coating substance, and the implantable device is again centrifuged, resulting in an even second coating. In another embodiment, a first coating substance is applied to an interior surface of a cylindrical implantable device, such as a stent or graft, and a second coating substance is applied to an exterior surface. A centrifuge step is performed so that the first coating substance is preferentially and uniformly applied on the interior surface of the implantable device and the second coating substance is preferentially and uniformly applied on the exterior surface of the implantable device.

    摘要翻译： 公开了用于涂覆可植入装置的不同区域的方法。 该方法的一个实施例包括将可植入装置的第一部分浸入第一涂层物质中，然后将可植入装置离心以提供均匀的涂层。 接下来，将可植入装置的第二部分浸入第二涂层物质中，并将可植入装置再次离心，从而形成均匀的第二涂层。 在另一个实施方案中，将第一涂层物质施加到诸如支架或移植物的圆柱形可植入装置的内表面，并且将第二涂层物质施加到外表面。 执行离心机步骤，使得第一涂层物质优先均匀地施加在可植入装置的内表面上，并且第二涂层物质优先均匀地施加在可植入装置的外表面上。

    Selective coating of medical devices
    65.
    发明授权
    Selective coating of medical devices 有权
    医疗器械的选择性涂层

    公开(公告)号：US06783793B1

    公开(公告)日：2004-08-31

    申请号：US09697106

    申请日：2000-10-26

    申请人： Syed F. A. Hossainy ,  Daryush Mirzaee

    发明人： Syed F. A. Hossainy ,  Daryush Mirzaee

    IPC分类号： B05D300

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/608

    摘要： Methods for coating different regions of an implantable device are disclosed. An embodiment of the method includes dipping a first portion of the implantable device into a first coating substance, and then centrifuging the implantable device to provide an even coating. Next, a second portion of the implantable device is dipped into a second coating substance, and the implantable device is again centrifuged, resulting in an even second coating. In another embodiment, a first coating substance is applied to an interior surface of a cylindrical implantable device, such as a tent or graft, and a second coating substance is applied to an exterior surface. A centrifuge step is performed so that the first coating substance is preferentially and uniformly applied on the interior surface of the implantable device and the second coating substance is preferentially and uniformly applied on the exterior surface of the implantable device.

    摘要翻译： 公开了用于涂覆可植入装置的不同区域的方法。 该方法的一个实施例包括将可植入装置的第一部分浸入第一涂层物质中，然后将可植入装置离心以提供均匀的涂层。 接下来，将可植入装置的第二部分浸入第二涂层物质中，并将可植入装置再次离心，从而形成均匀的第二涂层。 在另一个实施方案中，将第一涂层物质施加到诸如帐篷或移植物的圆柱形可植入装置的内表面，并且将第二涂层物质施加到外表面。 执行离心机步骤，使得第一涂层物质优先均匀地施加在可植入装置的内表面上，并且第二涂层物质优先均匀地施加在可植入装置的外表面上。

    Composite stent with regioselective material
    67.
    发明授权
    Composite stent with regioselective material 有权
    具有区域选择性材料的复合支架

    公开(公告)号：US06656216B1

    公开(公告)日：2003-12-02

    申请号：US09895753

    申请日：2001-06-29

    申请人： Syed F. A. Hossainy ,  Orlando Padilla ,  Daryush Mirzaee

    发明人： Syed F. A. Hossainy ,  Orlando Padilla ,  Daryush Mirzaee

    IPC分类号： A61F206

    CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/075 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2230/0076 ,  A61F2250/0018 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  Y10S623/916

    摘要： A composite stent and methods for making the same are provided. In one embodiment a regioselective band is formed in situ on the stent. In one embodiment, the band is made of a regioselective material having a high creep compliance and having a second modulus of elasticity lower than that of a structural material comprising the stent. In one embodiment, the regioselective material is drip-coated or dip-coated on the stent near the ends. In one embodiment, the regioselective material includes a therapeutic agent, which may be a radioactive emitter, an anti-platelet drug, or an anti-proliferative drug.

    摘要翻译： 提供复合支架及其制造方法。 在一个实施例中，在支架上原位形成区域选择性带。 在一个实施方案中，带由区域选择性材料制成，具有高蠕变柔量并且具有低于包含支架的结构材料的第二弹性模量。 在一个实施方案中，区域选择性材料在端部附近滴加或浸涂在支架上。 在一个实施方案中，区域选择性材料包括治疗剂，其可以是放射性发射体，抗血小板药物或抗增殖药物。

    Double tube stent
    68.
    发明授权
    Double tube stent 有权
    双管支架

    公开(公告)号：US06641607B1

    公开(公告)日：2003-11-04

    申请号：US09753294

    申请日：2000-12-29

    申请人： Syed F. A. Hossainy ,  Shamim M. Malik ,  Steven Wu

    发明人： Syed F. A. Hossainy ,  Shamim M. Malik ,  Steven Wu

    IPC分类号： A61F206

    CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0095 ,  A61F2230/0054 ,  A61F2250/0068 ,  A61F2250/0098

    摘要： A stent or intraductal medical device manufactured from a tubular member having an inner tube tightly fitted into an outer tube is provided. Microdepots may be formed on the outer surface of the inner tube, and may contain radioactive, radiopaque or therapeutic substances. A method for manufacturing such a medical device or stent is also described. The material to be deposited on the inner tube may be deposited on the inner tube by dipping or immersion, or the material may be applied to the inner tube using micro-injection or electrodeposition. The material to be deposited may be applied to cavities or microdepots formed in the outer surface of the inner tube. Excess material may be removed from the inner tube by centrifugation or shaking, and the material to be deposited may be heated to bond the material to the surface of the microdepots on the inner tube.

    摘要翻译： 提供了由具有紧密配合到外管中的内管的管状构件制造的支架或导管内医疗装置。 微口可以形成在内管的外表面上，并且可以包含放射性，不透射线或治疗物质。 还描述了制造这种医疗装置或支架的方法。 要沉积在内管上的材料可以通过浸渍或浸渍沉积在内管上，或者可以使用微注射或电沉积将材料施加到内管。 待沉积的材料可以应用于形成在内管的外表面中的腔或微口。 可以通过离心或摇动从内管中除去多余的材料，并且可以加热待沉积的材料以将材料粘合到内管上的微口头表面上。