公开(公告)号：US4521252A

公开(公告)日：1985-06-04

申请号：US420702

申请日：1982-09-21

申请人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

发明人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

IPC分类号： C07H3/04 ,  C13D3/12 ,  C13D3/14

CPC分类号： C07H3/04

摘要： The present invention relates to a process for producing a high-purity isomaltose by applying an aqueous solution, containing isomaltose, to a column packed with a strongly-acidic cation exchange resin of alkali metal- or alkaline earth metal-form; and fractionating by charging water to obtain a high-isomaltose fraction with an isomaltose content of at least 40%, thereby enabling industrial-scale production of a high-purity isomaltose much easier at lower cost.

摘要翻译： 本发明涉及通过将含有异麦芽糖的水溶液施加到填充有碱金属或碱土金属形式的强酸性阳离子交换树脂的柱中来生产高纯度异麦芽糖的方法; 并通过加水分馏，得到异麦芽糖含量至少为40％的高异麦芽糖馏分，从而以较低成本容易地进行工业规模生产高纯度异麦芽糖。

公开(公告)号：US4487198A

公开(公告)日：1984-12-11

申请号：US402823

申请日：1982-07-28

申请人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

发明人： Toshio Miyake ,  Shuzo Sakai ,  Takashi Shibuya

IPC分类号： C13B20/14 ,  C13K7/00 ,  C13D3/14

CPC分类号： C13B20/144 ,  C13K7/00

摘要： High-purity maltose is produced by applying a feed starch sugar solution with a maltose content of at least 70% to a column packed with a strongly-acidic cation exchange resin of alkali metal- or alkaline earth metal-form; fractionating the feed solution by charging water thereto into a high-dextrin fraction, a high-dextrin.maltose fraction, a high-maltose fraction, a high-maltose.glucose fraction, and a high-glucose fraction, in the given order; and recovering the high-maltose fraction. This process constantly provides a fraction with a maltose content of 93% or higher, and enables industrial-scale production of a high-purity maltose much easier and at lower-cost than conventional processes.

摘要翻译： 通过将麦芽糖含量至少为70％的饲料淀粉糖溶液施加到填充有碱金属或碱土金属形式的强酸性阳离子交换树脂的柱中来制备高纯度麦芽糖; 通过以给定的顺序将水加入到高糊精级分，高糊精麦芽糖级分，高麦芽糖级分，高麦芽糖葡萄糖级分和高葡萄糖级分中来分级进料溶液; 并回收高麦芽糖馏分。 该方法不断提供麦芽糖含量为93％或更高的分数，并使得工业规模生产高纯度麦芽糖比常规方法更容易和成本更低。

公开(公告)号：US08765416B2

公开(公告)日：2014-07-01

申请号：US12875786

申请日：2010-09-03

申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C12P19/44

CPC分类号： C12P19/60 ,  A23L33/10 ,  A23L33/15 ,  A61K8/0241 ,  A61K8/676 ,  A61K8/732 ,  A61K31/7048 ,  A61K2800/57 ,  A61K2800/654 ,  A61Q19/02 ,  C07H17/04 ,  Y10T428/2982

摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid; and by providing a process for producing the same and uses thereof.

摘要翻译： 本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。 本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上; 并提供其制造方法及其用途。

公开(公告)号：US20140178943A9

公开(公告)日：2014-06-26

申请号：US13980223

申请日：2012-03-07

申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C12P19/18

CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

公开(公告)号：US20130195941A1

公开(公告)日：2013-08-01

申请号：US13704814

申请日：2011-06-17

申请人： Takashi Shibuya ,  Seisuke Izawa ,  Toshio Miyake

发明人： Takashi Shibuya ,  Seisuke Izawa ,  Toshio Miyake

IPC分类号： C12P19/10 ,  A61K8/73 ,  A23L1/03 ,  A61K47/36

CPC分类号： C12P19/10 ,  A61K8/022 ,  A61K8/73 ,  A61K47/36 ,  A61K2800/10 ,  A61Q19/00 ,  C08B37/0018 ,  C08L5/00 ,  C12R1/645

摘要： The present invention aims to provide a particulate composition containing pullulan, which can be produced without employing any complicated purification step such as solvent precipitation and, when formed into a film, exhibits a higher rupture strength compared to conventional ones; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing pullulan which is produced from a culture obtained by culturing a mutant of a microorganism of the species Aureobasidium pullulans in a culture medium containing glucose and maltose as carbon sources, without employing a step of removing concomitant saccharides; contains a pullulan fraction and a concomitant saccharide fraction that are respectively insoluble and soluble in 75% by volume of methanol in water; has a percentage of 3% by weight or lower of the content of concomitant saccharides contained in the concomitant saccharide fraction against the content of total saccharides contained in the whole particulate composition, when determined based on the anthrone sulfuric acid method; and contains mannitol; and by providing the process of the same and uses thereof.

摘要翻译： 本发明的目的在于提供一种含有支链淀粉的颗粒组合物，其可以在不使用任何复杂的纯化步骤如溶剂沉淀的情况下制备，并且当形成膜时，与常规的相比，具有更高的断裂强度; 其制造方法; 及其用途。 本发明通过提供一种含有支链淀粉的颗粒组合物，其中所述组合物由通过培养含有葡萄糖和麦芽糖作为碳源的培养基中的优质链霉菌种的微生物的突变体获得的培养物而得到，而不采用以下步骤： 去除伴随的糖类; 含有不溶于75％（体积）甲醇的水中的支链淀粉部分和伴随的糖类部分。 当根据蒽酮硫酸法测定时，伴随糖类成分中所含的伴随糖含量相对于全部颗粒组合物中所含的总糖含量为3重量％以下的百分比; 并含有甘露醇; 并通过提供相同的方法和使用它们。

公开(公告)号：US5916881A

公开(公告)日：1999-06-29

申请号：US942266

申请日：1997-10-01

申请人： Katsuhide Okada ,  Takashi Shibuya ,  Toshio Miyake

发明人： Katsuhide Okada ,  Takashi Shibuya ,  Toshio Miyake

IPC分类号： C07H3/04 ,  A61K31/70 ,  A23G3/00 ,  A61K31/715 ,  C12P19/14

CPC分类号： C07H3/04

摘要： A non- or substantially non-crystalline high trehalose content syrup, which dissolves trehalose in an amount over the water solubility and dissolves other oligosaccharide having a trehalose structure within the molecule. The oligosaccharide acts as a trehalose crystallization inhibitory agent and makes the syrup stable, free of or substantially free of crystallization at ambient temperature, and free from bacterial contamination. Examples of the oligosaccharide are monoglucosyltrehalose, diglucosyltrehalose, and triglucosyltrehalose.

摘要翻译： 一种非或基本上非结晶的高海藻糖含量糖浆，其以高于水溶解度的量溶解海藻糖并溶解分子内具有海藻糖结构的其它寡糖。 寡糖作为海藻糖结晶抑制剂起作用，并且使糖浆在环境温度下稳定，不含或基本上不结晶，并且没有细菌污染。 寡糖的实例是单葡萄糖基海藻糖，二葡糖基海藻糖和三葡糖基海藻糖。

公开(公告)号：US5604211A

公开(公告)日：1997-02-18

申请号：US347222

申请日：1994-11-23

申请人： Takashi Shibuya ,  Hiroto Chaen ,  Shuzo Sakai ,  Toshio Miyake

发明人： Takashi Shibuya ,  Hiroto Chaen ,  Shuzo Sakai ,  Toshio Miyake

IPC分类号： A23L1/09 ,  A61K31/70 ,  A61K31/715 ,  A23G3/00

CPC分类号： A61K31/70 ,  A23L29/30

摘要： A composition for supplementing energy to a living body containing neotrehalose as effective ingredient. Neotrehalose is a disaccharide, therefore, when used in an energy supplementing composition, provides twice as much energy as does a monosaccharide. Neotrehalose has non-reducing properties, and this renders the composition containing neotrehalose stable for a relatively-long time period.

摘要翻译： 用于将能量补充到含有新海藻糖作为有效成分的活体的组合物。 新海藻糖是二糖，因此当用于能量补充组合物时，其能量是单糖的两倍。 新海藻糖具有非还原性，这使得含有新海藻糖的组合物在相当长的时间内稳定。

公开(公告)号：US5578469A

公开(公告)日：1996-11-26

申请号：US22340

申请日：1993-02-24

申请人： Takashi Shibuya ,  Hiroto Chaen ,  Shuzo Sakai ,  Toshio Miyake

发明人： Takashi Shibuya ,  Hiroto Chaen ,  Shuzo Sakai ,  Toshio Miyake

IPC分类号： A23C9/13 ,  A23C9/152 ,  A23G1/00 ,  A23G1/30 ,  A23G3/00 ,  A23G3/34 ,  A23G4/00 ,  A23L2/39 ,  A23L9/20 ,  A23L15/00 ,  A23L21/10 ,  A23L27/30 ,  A23L33/20 ,  A61K9/28 ,  A61K31/70 ,  A61P3/00 ,  A61P7/00 ,  A61P17/00 ,  C12P19/12 ,  C12P19/14 ,  C12P1/04 ,  A61K38/43 ,  A61K38/46

CPC分类号： C12P19/14 ,  C12P19/12 ,  Y10S435/839

摘要： Disclosed are a novel preparation of neotrehalose and its uses. The preparation comprises allowing .alpha.-amylase to act on an amylaceous substance to form neotrehalose, and recovering said neotrehalose. The neotrehalose has a satisfiable chemical stability, as well as other properties such as a sweeteness, energy-imparting ability, osmosis-regulating ability, filler-imparting ability, gloss-imparting ability, moisture-retaining ability, viscosity-imparting ability, crystallization-preventing ability, and non-fermentability. These properties render the neotrehalose advantageously useful in preparations of a variety of compositions.

摘要翻译： 公开了新海藻糖及其用途的新型制备方法。 该制剂包括使α-淀粉酶作用于淀粉物质以形成新海藻糖，并回收所述新海藻糖。 新海藻糖具有令人满意的化学稳定性，以及其它性能，如甜度，能量赋予能力，渗透调节能力，赋予赋形能力，赋予光泽的能力，保湿能力，粘度赋予能力， 预防能力和不发酵能力。 这些性质使得新海藻糖有利地用于各种组合物的制备。

公开(公告)号：US5550226A

公开(公告)日：1996-08-27

申请号：US316372

申请日：1994-10-03

申请人： Masaru Yoneyama ,  Takashi Shibuya ,  Toshio Miyake

发明人： Masaru Yoneyama ,  Takashi Shibuya ,  Toshio Miyake

IPC分类号： A23G1/00 ,  A23G1/40 ,  A23G3/00 ,  A23G3/42 ,  A23G4/00 ,  A23G4/10 ,  A23L1/22 ,  A23L1/236 ,  A23L1/308 ,  A23L2/60 ,  A61K8/73 ,  A61K9/20 ,  A61Q1/00 ,  A61Q11/00 ,  A61Q19/00 ,  C07H1/06 ,  C07H3/04 ,  C07H3/06 ,  C13K13/00 ,  C13K1/08

CPC分类号： A23G1/40 ,  A23G3/42 ,  A23G4/10 ,  A23L2/60 ,  A23L27/30 ,  A23L27/33 ,  A23L27/70 ,  A23L33/21 ,  A61K8/73 ,  A61K9/2018 ,  A61Q1/00 ,  A61Q11/00 ,  A61Q19/00 ,  C07H1/06 ,  C07H3/06

摘要： A novel panose-rich saccharide powder which contains 48-93 w/w % panose, d.s.b., together with other oligo-saccharides, and has a crystallinity of 19% or higher on x-ray powder diffraction analysis. The saccharide powder has a substantial non-hygroscopicity, as well as a satisfiable free-flowing ability and stability. Thus, the saccharide powder is advantageously used in food products, cosmetics and pharmaceuticals.

摘要翻译： 一种新颖的富含糖的糖类粉末，其含有48-93w / w％的panose，d.s.b.以及其它低聚糖，并且在X射线粉末衍射分析中具有19％或更高的结晶度。 糖粉具有显着的非吸湿性，以及令人满意的自由流动能力和稳定性。 因此，糖粉末有利地用于食品，化妆品和药物。

公开(公告)号：US09215887B2

公开(公告)日：2015-12-22

申请号：US12990729

申请日：2009-04-27

申请人： Kenshi Yoshida ,  Ikuo Sawatani ,  Hiroto Chaen ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Kenshi Yoshida ,  Ikuo Sawatani ,  Hiroto Chaen ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： A23L1/09 ,  A23L1/236 ,  A23C9/13 ,  A23C9/154 ,  A23C11/04 ,  A23K1/16 ,  A23L1/03 ,  A23L1/06 ,  A23L1/272 ,  A23L2/60 ,  C12P19/00 ,  C12P19/18 ,  A23L1/30

CPC分类号： A23L1/2363 ,  A23C9/1307 ,  A23C9/1544 ,  A23C11/04 ,  A23K20/10 ,  A23K20/163 ,  A23L2/60 ,  A23L5/00 ,  A23L5/41 ,  A23L7/00 ,  A23L21/00 ,  A23L21/10 ,  A23L27/33 ,  A23L29/035 ,  A23L29/30 ,  A23V2002/00 ,  C12P19/00 ,  C12P19/18 ,  C12Y204/01019 ,  C12Y302/01026 ,  A23V2250/61 ,  A23V2250/606 ,  A23V2250/5046

摘要： The objects of the present invention are to provide a method for inhibiting the coloration of a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a β-fructofuranosidic linkage, without deteriorating the taste inherent to the syrupy sweetener; and to provide a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a β-fructofuranosidic linkage, which is stabilized by the method. The present invention attains the above objects by providing a method for inhibiting the coloring of a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a β-fructofuranosidic linkage, which comprises a step of incorporating a lactate into the syrupy sweetener, and by providing a syrupy sweetener, comprising a reducing saccharide together with a non-reducing oligosaccharide having a β-fructofuranosidic linkage, which is stabilized by the method.

摘要翻译： 本发明的目的是提供一种抑制糖浆状甜味剂的着色的方法，其包含还原糖与具有呋喃呋喃糖苷键的非还原性寡糖，而不会降低糖浆状甜味剂固有的味道; 并提供一种糖浆状甜味剂，其包含还原糖以及通过该方法稳定的具有呋喃呋喃糖苷键的非还原性寡糖。 本发明通过提供一种抑制糖浆状甜味剂着色的方法来实现上述目的，该方法包括还原糖以及具有呋喃呋喃糖苷键的非还原寡糖，其包括将乳酸盐掺入糖浆中的步骤 并且通过提供糖浆状甜味剂，其包含还原糖以及通过该方法稳定的具有呋喃呋喃糖苷键的非还原性寡糖。