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公开(公告)号：US10940131B2
公开(公告)日：2021-03-09
申请号：US16179763
申请日：2018-11-02
发明人： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
IPC分类号： A61K31/202 , A61K45/06 , A61K31/222 , A61K31/232 , A61K31/40 , A61K31/505 , A61K9/48 , A61K47/22 , A61K47/26 , A61K47/34 , A61K31/74 , A61P3/06
摘要： The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
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公开(公告)号：US10675263B2
公开(公告)日：2020-06-09
申请号：US16190412
申请日：2018-11-14
发明人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Joseph S. Zakrzewski
IPC分类号： A61K31/232 , A61K31/23 , A61P3/00 , A61P43/00 , A61P3/06
摘要： In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
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公开(公告)号：US10292959B2
公开(公告)日：2019-05-21
申请号：US15411500
申请日：2017-01-20
发明人： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
IPC分类号： A61K31/232 , G01N33/92 , G01N33/96
摘要： In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
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公开(公告)号：US10265287B2
公开(公告)日：2019-04-23
申请号：US15725617
申请日：2017-10-05
发明人： Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Mehar Manku
IPC分类号： A61K9/48 , A61P3/06 , A61K31/40 , A61K31/74 , A61K45/06 , A61K47/22 , A61K47/26 , A61K47/34 , A61K31/202 , A61K31/222 , A61K31/232 , A61K31/505
摘要： The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
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65.发明授权公开(公告)号：US09855240B2
公开(公告)日：2018-01-02
申请号：US15350312
申请日：2016-11-14
发明人： Joseph S. Zakrzewski
IPC分类号： A61K31/20 , A61K31/232 , A61K31/683 , A61K31/351 , A61K31/365 , A61K31/366 , A61K31/4365 , A61K31/275 , A61K31/145 , A61K31/41 , A61K31/42 , A61K31/4166 , A61K31/19 , A61K31/22 , A61K31/047 , A61K31/10 , A61K31/194
CPC分类号： A61K31/232 , A61K31/045 , A61K31/047 , A61K31/10 , A61K31/145 , A61K31/19 , A61K31/194 , A61K31/202 , A61K31/22 , A61K31/275 , A61K31/351 , A61K31/365 , A61K31/366 , A61K31/41 , A61K31/4166 , A61K31/42 , A61K31/4365 , A61K31/683 , A61K2300/00
摘要： The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
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公开(公告)号：US09693986B2
公开(公告)日：2017-07-04
申请号：US15427238
申请日：2017-02-08
发明人： Paresh Soni
IPC分类号： A61K31/232 , A61K31/397 , A61K45/06
CPC分类号： A61K31/232 , A61K31/397 , A61K45/06 , A61K2300/00
摘要： In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
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公开(公告)号：US09693985B2
公开(公告)日：2017-07-04
申请号：US15422634
申请日：2017-02-02
发明人： Paresh Soni
IPC分类号： A61K31/232 , A61K31/397 , A61K45/06
CPC分类号： A61K31/232 , A61K31/397 , A61K45/06 , A61K2300/00
摘要： In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
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公开(公告)号：US09610272B2
公开(公告)日：2017-04-04
申请号：US15333991
申请日：2016-10-25
发明人： Paresh Soni
IPC分类号： A61K31/232 , A61K31/397 , A61K45/06
CPC分类号： A61K31/232 , A61K31/397 , A61K45/06 , A61K2300/00
摘要： In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.
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公开(公告)号：US20150216831A1
公开(公告)日：2015-08-06
申请号：US14261160
申请日：2014-04-24
发明人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni , Joseph S. Zakrzewski
IPC分类号： A61K31/232
CPC分类号： A61K31/232
摘要： In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of blood lipid therapy comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.
摘要翻译： 在各种实施方案中，本发明提供了治疗和/或预防心血管相关疾病，特别是血脂治疗方法的方法，其包括向有需要的受试者施用包含二十碳五烯酸或其衍生物的药物组合物。
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公开(公告)号：US09072715B2
公开(公告)日：2015-07-07
申请号：US14259724
申请日：2014-04-23
发明人： Mehar Manku , Ian Osterloh , Pierre Wicker , Rene Braeckman , Paresh Soni
IPC分类号： A61K31/202
CPC分类号： A61K31/202 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K31/232 , A61K45/06
摘要： The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
摘要翻译： 本发明尤其涉及包含多不饱和脂肪酸的药物组合物以及使用该药物组合物治疗或预防心血管相关疾病的方法。
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