公开(公告)号：US3794637A

公开(公告)日：1974-02-26

申请号：US3794637D

申请日：1971-07-22

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WIEDEMANN F ,  THIEL M ,  HARDEBECK K ,  STACH K ,  ROESCH E

IPC分类号： C07D471/04 ,  C07D51/46

CPC分类号： C07D471/04 ,  Y10S514/869

摘要： PYRIDO-(2,3-D)PYRIMIDIN-4(3H)-ONES OF THE GENERAL FORMULA 2-(R1-N(-R2)-),4-(O=)-3,4-DIHYDROPYRIDO(2,3-D)PYRIMIDINE WHEREIN R1 IS A LOWER ALKYL, ALKENUL, CYCLOALKYL, ARALKYL, FURYLALKYL, THIENYLALKYL OR TETRAHYDROFURYLALKYL RADICAL, OPTIONALLY SUBSTITUTED BY HYDROXY. ALKOXY OR ALKYLMERCAPTO RADICALS AND R2 IS R1 OR HYDROGEN, AND THE SALTS THEREOF WITH PHYSIOLOGICALLY COMPATIBLE ACIDS. THESE COMPOUNDS EXHIBIT LONGLASTING DIURETIC ACTION.

公开(公告)号：US3784006A

公开(公告)日：1974-01-08

申请号：US3784006D

申请日：1972-06-28

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BRAUN H

IPC分类号： B07C5/06 ,  B07C

CPC分类号： B07C5/065 ,  Y10S209/906 ,  Y10S209/914 ,  Y10S209/92

摘要： Apparatus for sorting dragees according to diameter and thickness of the dragees, which apparatus comprises, in combination, (a) plate-type sorting means comprising a perforated surface adjustable in tilt and oscillatable and disposed to receive the dragees to be sorted and, disposed therebelow, (b) roller-type sorting means comprising a plurality of substantially parallel rollers wherein adjacent rollers rotate in opposite directions and wherein the spacing between said rollers is steplessly adjustable.

摘要翻译： 用于根据糖衣丸的直径和厚度分配糖衣丸的装置，该装置组合包括（a）板式分选装置，其包括可倾斜地调节并可摆放的穿孔表面，并设置成容纳待分类的糖衣并布置在其下方 ，（b）滚子式分选装置，其包括多个基本平行的辊，其中相邻的辊沿相反方向旋转，并且其中所述辊之间的间隔是无级可调的。

公开(公告)号：US3781273A

公开(公告)日：1973-12-25

申请号：US3781273D

申请日：1971-02-03

申请人： BOEHRINGER MANNHEIM GMBH

发明人： KAMPE W ,  DIETMANN K ,  JUHRAN W ,  FAULAND E ,  THIEL M

IPC分类号： C07H19/167 ,  C07H19/16 ,  C07D51/54

CPC分类号： C07H19/16

摘要： NOVEL 2,3- OR 2-5 DISUBSTITUTED N (6)-BENZYL-ADENOSINE DERIVATIVES OF THE FOLLOWING FORMULA

9-(3,4,5-TRI(HO-)TETRAHYDROFUR-2-YL),6-((2-R1,3-R2,5-R3-

PHENYL)-CH2-NH-)-9H-PURINE

WHEREIN

R1 IS HALOGEN, ALKYL, ALKOXY OR ALKYLTHIO; R2 AND R3 ARE MEMBERS OF THE GROUP CONSISTING OF HYDROGEN, HALOGEN, ALKYL, ALKOXY AND ALKYLTHIO WITH THE PROVISO THAT ONE AND ONLY ONE OF R2 AND R3 IS HYDROGEN; ARE OUTSTANDING EFFECTIVE CORONARY DILATORS AND LOWER THE FREE FATTY ACID CONTENT OF SERUM.

公开(公告)号：US3763879A

公开(公告)日：1973-10-09

申请号：US3763879D

申请日：1971-02-18

申请人： BOEHRINGER MANNHEIM GMBH

发明人： JAWOREK D

IPC分类号： B01L3/00 ,  B01L3/14 ,  G01N30/46 ,  G01N30/58 ,  G01N30/60 ,  G01N30/84 ,  B01D35/28

CPC分类号： B01L3/5021 ,  B01L3/569 ,  G01N30/461 ,  G01N30/58 ,  G01N30/6026 ,  G01N30/6034 ,  G01N30/606 ,  G01N30/6069 ,  G01N30/6082 ,  G01N2030/8429 ,  Y10T137/4891 ,  Y10T137/8122

摘要： Combination columns comprised of individual connective parts, some of which may contain sieve means and other means, provide flexible and adaptive systems for effecting chemical processes such as column chromatography and involving carrier-bound reagents.

摘要翻译： 组合柱由单独的连接部件组成，其中一些部件可能含有筛装置和其他装置，为实现化学过程如柱色谱和涉及载体结合试剂提供灵活和适应性系统。

公开(公告)号：US3753975A

公开(公告)日：1973-08-21

申请号：US3753975D

申请日：1970-12-01

申请人： BOEHRINGER MANNHEIM GMBH

发明人： KAISER F ,  VOIGTLANDER W ,  SCHAUMANN W ,  STACH K

IPC分类号： C07J19/00 ,  A61K20060101 ,  A61K31/585 ,  A61K31/704 ,  A61P9/04 ,  C07C20060101 ,  C07C43/00 ,  C07J71/00 ,  C07C173/00

CPC分类号： C07J19/00

摘要： EVOMONOSIDE ETHERS AND/OR ESTERS OF THE FORMULA

17-(2-(O=)-2,5-DIHYDROFUR-4-YL),3-((3-(R3-O-),4-(R2-O-),

5-(R1-O-),5-(R2-O-),6-CH3-TETRAHYDROPYRAN-2-YL)-O-),14-

HO-ANDROSTANE

WHEREIN ONE OR TWO OF THE SUBSTITUENTS R1, R2 AND R3 IS LOWER ALKYL OR ALKOXYALKYL OR WHEREIN THE SUBSTITUENTS R2 AND R3 TOGETHER REPRESENT A LOWER ALKYLIDENE RADICAL, AND THE REMAINING SUBSTITUENTS ARE HYDROGEN OR ACYL. THESE EVOMONOSIDE DERIVATIVES ARE HIGHLY EFFECTIVE THERAPEUTIC AGENTS AND ARE SUITABLE FOR ORAL ADMINISTRATION IN THE TREATMENT OF CARDIAC INSUFFICIENCY.

公开(公告)号：US3721607A

公开(公告)日：1973-03-20

申请号：US3721607D

申请日：1971-08-11

申请人： BOEHRINGER MANNHEIM GMBH

发明人： GRUBER W ,  BERNT E ,  GAWEHN K ,  BERGMEYER H ,  WERNER W

IPC分类号： C12Q1/02 ,  C12Q1/28 ,  C12Q1/54 ,  C12K1/04

CPC分类号： C12Q1/54 ,  C12Q1/28 ,  C12Q2326/30

摘要： Compositions comprising glucose oxidase, peroxidase, a chromogen, a buffer, an azide, and 2,2''-azino-di-(3ethylbenzothiazoline-6-sulfonic acid) provide remarkably stable test reagents for the enzymatic determination of glucose.

公开(公告)号：US3707536A

公开(公告)日：1972-12-26

申请号：US3707536D

申请日：1970-04-13

申请人： BOEHRINGER MANNHEIM GMBH

发明人： HAID ERICH ,  NELBOECK-HOCHSTETTER MICHAEL

IPC分类号： C07H19/16 ,  C07H19/20 ,  C12P19/40 ,  C07D51/54

CPC分类号： C07H19/16 ,  C12P19/40

摘要： S-ADENOSYL-1-METHIONINE AND S-ADENOSYL-1-ETHIONINE ARE OBTAINED FROM YEAST IN SUBSTANTIALLY PURE FORM AND IN HIGH YIELD BY SUBJECTING THE YEAST TO ACID DIGESTION AND CATION EXCHANGE CHROMATOGRAPHY AND TO EITHER ONE OR BOTH OF THE PROCESS STEPS OF (1) PICRIC ACID PRECIPITATION AND (2) BORIC ACID ADDITION TO GIVE A BORATE COMPLEX WHICH IS THEN CHROMATOGRAPHED THROUGH AN ANION EXCHANGER AT A WEAKLY ALKALINE PH, WHICH PROCESS STEPS (1) AND (2), IF BOTH ARE UTILIZED, CAN BE CARRIED OUT IN EITHER SEQUENC. NEW S-ADENOSYL-1-METHIONINE BISUFATE AND S-ADENOSYL-1-ETHIONINE OF EXCEPTIONAL STABILITY ARE ALSO PROVIDED.

公开(公告)号：US3652568A

公开(公告)日：1972-03-28

申请号：US3652568D

申请日：1969-09-15

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WINTER WERNER ,  THIEL MAX ,  STACH KURT ,  SCHAUMANN WOLFGANG ,  DIETMANN KARL ,  JUHRAN WOLFGANG

IPC分类号： C07D295/088 ,  C07D295/15 ,  C07D51/70

CPC分类号： C07D295/088 ,  C07D295/15

摘要： BASIC ETHERS CHARACTERIZED BY CORONARY DILATING ACTIVITY HAVING THE FORMULA:

1-((R1-PHENYL)-CH(-PHENYLENE-R2)-O-(CH2)N-),4-((R3,R4,R5-

(PHENYL)-NH-CO-CH2-)PIPERAZINE

WHEREIN R1 AND R2 EACH DESIGNATE HYDROGEN, HALOGEN OR LOWER ALKYL, R3, R4 AND R5 EACH DISIGNATE HYDROGEN, HALOGEN, LOWER ALKYL, ALKOXY OR TRIFLUOROMETHYL, AND N IS 2 OR 3, AND NON TOXIC SALTS OF SAID BASIC ETHERS.

公开(公告)号：US3639211A

公开(公告)日：1972-02-01

申请号：US3639211D

申请日：1968-11-19

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BEAUCAMP KLAUS

IPC分类号： A23J3/00 ,  C07F9/22 ,  C12D13/06

CPC分类号： C07F9/222 ,  A23J3/04

摘要： Process for preparing creatine phosphate comprising incubating in an alkaline medium creatine and 3-phosphoglyceric acid with an aqueous muscle extract in the presence of a catalytic amount of adenosine triphosphate, heating the resulting mixture for a short period of time to a temperature of 70* to 100* C. and recovering the creatine phosphate which is thereby formed.

摘要翻译： 制备肌酸磷酸盐的方法包括在催化量的三磷酸腺苷存在下，用肌肉提取液在碱性介质肌酸和3-磷酸甘油酸中孵育，将所得混合物短时间内加热至70℃至 并回收由此形成的磷酸肌酸。

公开(公告)号：US3630847A

公开(公告)日：1971-12-28

申请号：US3630847D

申请日：1968-07-17

申请人： BOEHRINGER MANNHEIM GMBH

发明人： REY HANS-GEORG ,  WIELINGER HANS ,  RIECKMANN PETER

IPC分类号： G01N33/50 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N31/14

CPC分类号： C12Q1/28 ,  C12Q1/54 ,  C12Q2326/00 ,  Y10S435/805 ,  Y10S436/904

摘要： IN WHICH R1 is hydroxyl, unsubstituted or substituted amino, wherein the substituent is an aliphatic, araliphatic, cycloaliphatic, heterocyclic or aromatic radical, which in turn is substituted by one or more of hydroxy, amino and alkoxy; R3, R2 and R5 are each one of hydrogen, amino, hydroxy or alkoxy and R4 is hydrogen or the substituent R1. The diagnostic agents can be used for analytical determinations involving, for example, glucose, galactose, amino acids, uric acid, peroxide, hemoglobin, peroxidase, etc. in samples, for example, constituting biological fluids such as blood, urine, spinal fluid, etc., milk, cosmetic and drug formulations, etc.

Diagnostic agents suitable for use in carrying out rapid analytical determinations of the presence and/or concentration of hydroperoxide substances which react with the liberation of hydrogen peroxide, peroxidase and peroxidate active substances comprising an indicator, i.e., chromogen, which is oxidized by hydrogen peroxide, peroxidase or peroxidate active substances to form a dyestuff, the color intensity of which is dependent on the peroxide, peroxidase or peroxidate active substance present in the test sample, wherein the chromogen is a compound having the formula: