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![8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2011/02/15/US07888358B2/abs.jpg.150x150.jpg)
71.发明授权8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07888358B2
公开(公告)日：2011-02-15
申请号：US12216213
申请日：2008-07-01
申请人： Dan Peters , Birgitte L. Eriksen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
发明人： Dan Peters , Birgitte L. Eriksen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
IPC分类号： A61K31/46 , A61K31/498 , A61P25/00 , C07D451/00
CPC分类号： C07D451/04 , C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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72.发明授权Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权色烯-2-酮衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07696350B2
公开(公告)日：2010-04-13
申请号：US11661966
申请日：2005-09-28
IPC分类号： C07D221/02 , C07D225/00 , C07D401/00
CPC分类号： C07D405/12 , C07D451/06 , C07D451/12
摘要： This invention relates to chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的色烯-2-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2009/04/28/US07524958B2/abs.jpg.150x150.jpg)
73.发明授权Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效某些9-氮杂 - 双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07524958B2
公开(公告)日：2009-04-28
申请号：US11579056
申请日：2005-06-14
IPC分类号： C07D221/02 , A61K31/44
CPC分类号： C07D451/14
摘要： This invention relates to novel 9-aza-bicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型9-氮杂 - 双环[3.3.1]壬烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2008/08/05/US07407970B2/abs.jpg.150x150.jpg)
74.发明授权8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07407970B2
公开(公告)日：2008-08-05
申请号：US10561417
申请日：2004-06-18
申请人： Dan Peters , Birgitte L. Eriksen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
发明人： Dan Peters , Birgitte L. Eriksen , Elsebet Østergaard Nielsen , Jørgen Scheel-Krüger , Gunnar M. Olsen
IPC分类号： A01N43/42 , A61K31/44 , C07D451/00 , C07D451/02
CPC分类号： C07D451/04 , C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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公开(公告)号：US07378526B2
公开(公告)日：2008-05-27
申请号：US10513416
申请日：2003-05-06
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Philip K. Ahring
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Philip K. Ahring
IPC分类号： C07D401/00 , C07D451/02 , C07D405/00
CPC分类号： C07D451/02 , C07D211/70 , C07D453/02
摘要： This invention relates to novel azacyclic ethynyl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新颖的氮杂环乙炔衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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公开(公告)号：US07300933B2
公开(公告)日：2007-11-27
申请号：US10513398
申请日：2003-05-06
申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Philip K. Ahring
发明人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen , Philip K. Ahring
IPC分类号： C07D403/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/40 , A61K31/381 , A61K31/34 , A61P25/04 , A61P25/28 , A61P31/30
CPC分类号： C07D487/08
摘要： This invention relates to novel diazabicyclic biaryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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77.发明授权8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效8-氮杂 - 双环（3.2.1）辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07247643B2
公开(公告)日：2007-07-24
申请号：US10544027
申请日：2004-02-10
IPC分类号： A01N43/42 , A61K31/44 , C07D451/02
CPC分类号： C07D451/02
摘要： This invention relates to novel 8-aza-bicyclop[3.2.1]octane derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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公开(公告)号：US07202237B2
公开(公告)日：2007-04-10
申请号：US10848132
申请日：2004-05-19
IPC分类号： C07D401/12 , A61K31/55
CPC分类号： C07D401/02 , C07D401/12 , C07D403/12
摘要： The present invention relates to novel pyridylether derivatives which are cholinergic ligands at nicotinic Ach receptors. The compounds of the invention are useful for the treatment of conditions, disorders, or diseases involving the cholinergic system of the central nervous system, pain, inflammatory diseases, diseases caused by smooth muscle contractions and as assistance in the cessation of chemical substance abuse.
摘要翻译： 本发明涉及新颖的吡啶基醚衍生物，它们是烟碱型Ach受体的胆碱能配体。 本发明的化合物可用于治疗涉及中枢神经系统的胆碱能系统，疼痛，炎性疾病，由平滑肌收缩引起的疾病以及停止化学物质滥用的协助的疾病，病症或疾病。
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公开(公告)号：US07060699B2
公开(公告)日：2006-06-13
申请号：US10276160
申请日：2001-06-20
申请人： Dan Peters , Gunnar M Olsen , Elsebet Østergaard Nielsen , Philip K. Ahring , Simon Feldbæk Nielsen , Tino Dyhring Jørgensen
发明人： Dan Peters , Gunnar M Olsen , Elsebet Østergaard Nielsen , Philip K. Ahring , Simon Feldbæk Nielsen , Tino Dyhring Jørgensen
IPC分类号： C07D487/08 , C07D471/08 , A61K31/551 , A61K31/395 , A61P25/28
CPC分类号： C07D487/08
摘要： The present invention relates to novel aryl and heteroaryl diazabicycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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80.发明申请TREATMENT OF AFFECTIVE DISORDERS BY THE COMBINED ACTION OF A NICOTINIC RECEPTOR AGONIST AND A MONOAMINERGIC SUBSTANCE 审中-公开通过联合受体激动剂和单一药物的组合作用治疗感染性疾病公开(公告)号：US20100267739A1
公开(公告)日：2010-10-21
申请号：US12784890
申请日：2010-05-21
IPC分类号： A61K31/496 , C07D401/04 , A61P25/00
CPC分类号： C07D403/04 , A61K31/00 , A61K31/439 , A61K31/4439 , A61K31/455 , A61K31/46 , A61K31/519 , A61K31/551 , A61K45/06 , C07D213/61 , C07D213/65 , C07D213/74 , C07D237/12 , C07D237/20 , C07D241/16 , C07D241/20 , C07D401/04 , C07D451/02 , C07D487/08 , A61K2300/00
摘要： The use of the combined action of a nicotinic acetylcholine receptor agonist and a monoaminergic substance for the treatment of affective disorders, as well as pharmaceutical compositions comprising these substances and chemical substances for use in such treatment.
摘要翻译： 使用烟碱乙酰胆碱受体激动剂和单胺能物质用于治疗情感障碍的联合作用，以及包含这些物质的药物组合物和用于这种治疗的化学物质。
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