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    NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE
    71.
    发明申请
    NOVEL DIBENZOFURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
    新型二苯并咪唑 - 氧化二氮杂双环十二烷基衍生物及其医疗用途

    公开(公告)号：US20120028968A1

    公开(公告)日：2012-02-02

    申请号：US13146240

    申请日：2010-01-25

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Østergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

    IPC分类号： A61K31/551 ,  A61P25/00 ,  A61P25/28 ,  A61P25/18 ,  A61P25/24 ,  A61P25/16 ,  A61P25/14 ,  A61P29/00 ,  A61P17/00 ,  A61P25/30 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P17/10 ,  C07D487/08

    CPC分类号： C07D471/08

    摘要： This invention relates to novel dibenzofuranyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的二苯并呋喃基 - 恶二唑基 - 二氮杂双环壬烷衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
    75.
    发明授权
    3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效
    3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途

    公开(公告)号：US07700596B2

    公开(公告)日：2010-04-20

    申请号：US12161905

    申请日：2007-02-09

    申请人： Dan Peters ,  John Paul Redrobe ,  Elsebet Østergaard Nielsen

    发明人： Dan Peters ,  John Paul Redrobe ,  Elsebet Østergaard Nielsen

    IPC分类号： A61K31/495

    CPC分类号： C07D471/08

    摘要： 3,9-diazabicyclo[3.3.1]nonane derivatives, useful as monoamine neurotransmitter re-uptake inhibitors. Also, use of these compounds in a method for therapy and in pharmaceutical compositions comprising the compounds. The 3,9-diazabicyclo[3.3.1]nonane derivatives have the formula wherein Ra and Rb are as described in the application. Also disclosed are stereoisomers and pharmaceutically acceptable salts of the compounds.

    摘要翻译： 3,9-二氮杂双环[3.3.1]壬烷衍生物，可用作单胺神经递质再摄取抑制剂。 此外，在治疗方法中使用这些化合物和包含该化合物的药物组合物。 3,9-二氮杂双环[3.3.1]壬烷衍生物具有下式其中Ra和Rb如申请中所述。 还公开了化合物的立体异构体和药学上可接受的盐。