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71.发明申请公开(公告)号：US20140005214A1
公开(公告)日：2014-01-02
申请号：US14005595
申请日：2012-03-14
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , A61K31/445
摘要： The present invention is directed to piperidinone carboxamide spirohydantoin derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮甲酰胺螺乙内酰脲衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07968540B2
公开(公告)日：2011-06-28
申请号：US12085008
申请日：2006-11-14
IPC分类号： A61K31/55 , C07D243/04 , C07D487/10
CPC分类号： C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, R6, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B1，B2，B3，B4，D1，D2，E1，E2，E3，E4，E5，G1，G2， T，U，V，W，X，Y和Z如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20100298269A1
公开(公告)日：2010-11-25
申请号：US12864120
申请日：2009-02-04
IPC分类号： A61K31/675 , C07F9/6561 , A61P29/00 , A61P3/10 , A61P9/00 , A61P11/06 , A61P19/02 , A61P17/00
CPC分类号： C07D471/04 , C07F9/6561
摘要： Disclosed are prodrug compounds of formula (I) (wherein variables R1 and R2 are as described herein) which are analogues of an antagonist of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 公开了式（I）的前药化合物（其中变量R 1和R 2如本文所述），其是CGRP受体的拮抗剂的类似物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20090281080A1
公开(公告)日：2009-11-12
申请号：US12085008
申请日：2006-11-14
IPC分类号： A61K31/55 , A61K31/4985 , A61K31/438 , C07D487/06 , C07D471/06
CPC分类号： C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B1, B2, B3, B4, D1, D2, E1, E2, E3, E4, E5, G1, G2, R6, T, U, V, W, X, Y and Z are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B1，B2，B3，B4，D1，D2，E1，E2，E3，E4，E5，G1，G2， T，U，V，W，X，Y和Z如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20090239870A1
公开(公告)日：2009-09-24
申请号：US12084917
申请日：2006-11-14
IPC分类号： A61K31/502 , C07D471/10 , A61K31/4747 , A61K31/496 , C07D487/10
CPC分类号： C07D487/10 , C07D471/10 , C07D519/00
摘要： Compounds of formula I: (wherein variables A1, A2, A3, A4, A5, A6, A7, B, E1, E2, E3, E4, E5, G1, G2 and R6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 式I化合物（其中变量A1，A2，A3，A4，A5，A6，A7，B，E1，E2，E3，E4，E5，G1，G2和R6如本文所述），其是CGRP受体的拮抗剂 并且其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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76.发明申请IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA SUCH AS STREPTOCOCCUS AGALACTIAE 有权AM AM E E E E E E E E E E E E E E E E E E E E E E E公开(公告)号：US20090221535A1
公开(公告)日：2009-09-03
申请号：US11662702
申请日：2005-09-09
IPC分类号： A61K31/60 , C07D487/06 , A61K31/4985 , A61K31/551 , A61P25/00 , A61K31/47 , A61K31/535
CPC分类号： C07D487/06 , C07D471/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, T, U, V, W, X, Y, Z. R4, R5a?, R5b, R5c, R6, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A1，A2，B1，B2，B3，B4，D1，D2，T，U，V，W，X，Y，Z.R4，R5a，R5b ，R 5，R 6，m和n如本文所定义），其可用作CGRP受体的拮抗剂，并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20080214511A1
公开(公告)日：2008-09-04
申请号：US11662246
申请日：2005-09-06
申请人： Ian M. Bell , Steven N. Gallicchiro , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
发明人： Ian M. Bell , Steven N. Gallicchiro , Craig A. Stump , Cory R. Theberge , Joseph P. Vacca , C. Blair Zartman , Xufang Zhang
IPC分类号： A61K31/437 , C07D471/06 , C07D487/06 , A61P25/00 , A61K31/55 , A61K31/53 , A61K31/4985 , A61K31/616 , A61K31/5415
CPC分类号： C07D519/00 , C07D209/96 , C07D471/06 , C07D471/16 , C07D487/06
摘要： The present invention is directed to compounds of Formula I: I (where A1, A2, B1, B2, B3, B4, D1, D2, J, K, T, U, V, W, X, Y, Z, R4, R5a, R5b, R5c, m and n are defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中A 1，A 2，B 1，B 2， B，S 4，B 4，D 1，D 2，J，K，T， U，V，W，X，Y，Z，R 4，R 5a，R 5b，R 5c， >，m和n在本文中定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07288559B2
公开(公告)日：2007-10-30
申请号：US10546889
申请日：2004-03-10
IPC分类号： A61K31/4166 , A61K31/4178 , A61K31/429 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/551 , A61K31/553 , C07D239/22
CPC分类号： C07D233/78 , C07D235/02 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D513/04
摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07205293B2
公开(公告)日：2007-04-17
申请号：US10547228
申请日：2004-03-10
IPC分类号： C07D403/12 , A61K31/55 , A61P25/06
CPC分类号： C07D403/12 , C07D235/02
摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07202251B2
公开(公告)日：2007-04-10
申请号：US10549338
申请日：2004-03-10
申请人： Ian M. Bell , Steven N. Gallicchio , Cory R. Theberge , Xu-Fang Zhang , Craig Stump , C. Blair Zartman
发明人： Ian M. Bell , Steven N. Gallicchio , Cory R. Theberge , Xu-Fang Zhang , Craig Stump , C. Blair Zartman
IPC分类号： A61K31/506 , A61K31/513 , A61K31/437 , A61K31/438 , A61K31/454 , A61K31/4439 , A61K31/427 , A61K31/423 , A61K31/4184 , A61K31/4166 , C07D239/34 , C07D239/42 , C07D211/98 , C07D211/32 , C07D277/38 , C07D277/68 , C07D235/26
CPC分类号： C07D401/14 , C07D233/76 , C07D235/02 , C07D235/26 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/10
摘要： The present invention is directed to compounds of the formula: that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及下式的化合物：
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