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    Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion
    71.
    发明授权
    Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion 有权
    质子产生导管及其用于增强通过钙化血管闭塞所占据的血管部位的流体流动的方法

    公开(公告)号：US07778701B2

    公开(公告)日：2010-08-17

    申请号：US11283052

    申请日：2005-11-17

    申请人： Brent R. Constantz ,  John Ross

    发明人： Brent R. Constantz ,  John Ross

    IPC分类号： A61M31/00

    CPC分类号： A61N1/306 ,  A61B17/22 ,  A61B18/00 ,  A61B18/1492 ,  A61B2017/22082

    摘要： Catheter devices and methods are provided for enhancing fluid flow through a vascular site occupied by a calcified lesion. The catheter devices of the subject invention at least include, at their distal end, a proton generating means, and in many embodiments also include a flushing means. In using the subject devices, the distal end of the catheter is placed proximal to the vascular occlusion and protons are generated, e.g., via proton generation from water, in a manner sufficient to reduce the pH of the vascular site in the region proximal to the occlusion. The subphysiologic pH is maintained for a period of time sufficient for fluid flow through the vascular site to be enhanced. Also provided are kits comprising the subject catheter devices for use in the subject methods.

    摘要翻译： 提供导管装置和方法用于增强通过钙化损伤占据的血管部位的流体流动。 本发明的导管装置至少在其远端包括质子产生装置，并且在许多实施例中还包括冲洗装置。 在使用本发明装置时，将导管的远端放置在血管闭塞附近，并且产生质子，例如，通过从水中产生质子，以足以降低近端的区域内的血管部位的pH值的方式产生质子 闭塞。 亚生物pH保持足够的时间足以使液体流过血管部位以增强。 还提供了包括用于本发明方法的主题导管装置的试剂盒。

    DESALINATION METHODS AND SYSTEMS THAT INCLUDE CARBONATE COMPOUND PRECIPITATION
    72.
    发明申请
    DESALINATION METHODS AND SYSTEMS THAT INCLUDE CARBONATE COMPOUND PRECIPITATION 审中-公开
    包含碳酸盐化合物降解的脱盐方法和系统

    公开(公告)号：US20100154679A1

    公开(公告)日：2010-06-24

    申请号：US12700193

    申请日：2010-02-04

    申请人： Brent R. Constantz ,  Kasra Farsad ,  Miguel Fernandez

    发明人： Brent R. Constantz ,  Kasra Farsad ,  Miguel Fernandez

    IPC分类号： C04B7/00 ,  C02F1/04 ,  C02F1/52 ,  C02F1/44

    CPC分类号： B01D61/025 ,  B01D2311/04 ,  B01D2311/06 ,  C02F1/04 ,  C02F1/441 ,  C02F1/5236 ,  C02F1/66 ,  C02F2103/08 ,  Y02A20/128 ,  Y02A20/131 ,  Y02W10/33 ,  Y02W10/37 ,  B01D2311/26 ,  B01D2311/103

    摘要： Desalination methods that include carbonate compound precipitation are provided. In certain embodiments, feed water is subjected to carbonate compound precipitation conditions prior to desalination. In certain embodiments, desalination waste brine is subjected to carbonate compound precipitation conditions. In yet other embodiments, both feed water and waste brine are subjected to carbonate compound precipitation conditions. Aspects of embodiments of the invention include carbon dioxide sequestration. Embodiments of the invention further employ a precipitate product of the carbonate compound precipitation conditions as a building material, e.g., a cement. Also provided are systems configured for use in methods of the invention.

    摘要翻译： 提供了包括碳酸盐化合物沉淀的脱盐方法。 在某些实施方案中，进料水在脱盐之前经受碳酸盐化合物沉淀条件。 在某些实施方案中，脱盐废盐水经受碳酸盐化合物沉淀条件。 在其他实施方案中，给水和废盐水都经受碳酸盐化合物沉淀条件。 本发明的实施方案的方面包括二氧化碳封存。 本发明的实施方案还使用碳酸酯化合物沉淀条件的沉淀产物作为建筑材料，例如水泥。 还提供了配置用于本发明方法的系统。

    Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue
    74.
    发明授权
    Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue 有权
    用于减少非内膜血管组织区域的矿物质含量的方法和装置

    公开(公告)号：US07670311B2

    公开(公告)日：2010-03-02

    申请号：US11267038

    申请日：2005-11-04

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61M31/00

    CPC分类号： A61B17/11 ,  A61B17/08 ,  A61B2017/00778 ,  A61B2017/00893 ,  A61B2017/1107 ,  A61N7/00

    摘要： Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue are provided. In the subject methods, an isolated local environment that includes the region to be demineralized is produced. The pH of the local environment is then reduced to a subphysiologic level, e.g. by flushing with an acidic dissolution fluid, for a period of time sufficient for the mineral content of the region to be reduced. The devices of the subject invention are characterized by comprising a means for producing an isolated local environment that includes a non-intimal region of vascular tissue. Also provided are kits for practicing the subject methods.

    摘要翻译： 提供了用于降低非内膜血管组织区域的矿物质含量的方法和装置。 在主题方法中，产生了包括待软化区域的孤立的局部环境。 然后将局部环境的pH降低至亚生理水平，例如 通过用酸性溶解流体冲洗一段足以减少该区域的矿物质含量的时间。 本发明的装置的特征在于包括用于产生包括血管组织的非内膜区域的分离的局部环境的装置。 还提供了用于实践主题方法的工具包。

    CALCIUM PHOSPHATE CEMENTS COMPRISING AUTOLOGOUS BONE
    76.
    发明申请
    CALCIUM PHOSPHATE CEMENTS COMPRISING AUTOLOGOUS BONE 有权
    包含自体骨的磷酸钙化合物

    公开(公告)号：US20080241206A1

    公开(公告)日：2008-10-02

    申请号：US11694807

    申请日：2007-03-30

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61K9/00

    CPC分类号： A61L27/365 ,  A61L27/12 ,  A61L27/3608 ,  A61L27/425

    摘要： Aspects of the invention include methods for producing flowable compositions, e.g. pastes, that set into calcium phosphate containing products, where the products include autologous bone. Aspects of the invention further include compositions produced by the methods, as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including hard tissue repair applications.

    摘要翻译： 本发明的方面包括用于生产可流动组合物的方法，例如。 糊剂，其中含有磷酸钙的产品，其中产品包括自体骨。 本发明的方面还包括通过该方法制备的组合物，以及制备该组合物的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括硬组织修复应用。

    Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occulation
    77.
    发明授权
    Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occulation 有权
    质子产生导管及其用于增强通过钙化血管闭塞所占据的血管部位的流体流动的方法

    公开(公告)号：US06719747B2

    公开(公告)日：2004-04-13

    申请号：US10358983

    申请日：2003-02-04

    申请人： Brent R. Constantz ,  John Ross

    发明人： Brent R. Constantz ,  John Ross

    IPC分类号： A61M3100

    CPC分类号： A61N1/306 ,  A61B17/22 ,  A61B18/00 ,  A61B18/1492 ,  A61B2017/22082

    摘要： Catheter devices and methods are provided for enhancing fluid flow through a vascular site occupied by a calcified lesion. The catheter devices of the subject invention at least include, at their distal end, a proton generating means, and in many embodiments also include a flushing means. In using the subject devices, the distal end of the catheter is placed proximal to the vascular occlusion and protons are generated, e.g., via proton generation from water, in a manner sufficient to reduce the pH of the vascular site in the region proximal to the occlusion. The subphysiologic pH is maintained for a period of time sufficient for fluid flow through the vascular site to be enhanced. Also provided are kits comprising the subject catheter devices for use in the subject methods.

    摘要翻译： 提供导管装置和方法用于增强通过钙化损伤占据的血管部位的流体流动。 本发明的导管装置至少在其远端包括质子产生装置，并且在许多实施例中还包括冲洗装置。 在使用本发明装置时，将导管的远端放置在血管闭塞附近，并且产生质子，例如，通过从水中产生质子，以足以降低近端的区域内的血管部位的pH值的方式产生质子 闭塞。 亚生物pH保持足够的时间足以使液体流过血管部位以增强。 还提供了包括用于本发明方法的主题导管装置的试剂盒。

    Calcium phosphate cements prepared from silicate solutions
    78.
    发明授权
    Calcium phosphate cements prepared from silicate solutions 有权
    由硅酸盐溶液制备的磷酸钙水泥

    公开(公告)号：US06375935B1

    公开(公告)日：2002-04-23

    申请号：US09561324

    申请日：2000-04-28

    申请人： Brent R. Constantz

    发明人： Brent R. Constantz

    IPC分类号： A61K716

    CPC分类号： A61L24/02 ,  A61K6/0612 ,  A61K6/0643 ,  A61K6/097 ,  A61L27/12 ,  Y10S514/951 ,  Y10S514/953 ,  A61K6/087 ,  C08L89/00

    摘要： Methods are provide for producing flowable compositions, e.g. pastes, that set into calcium phosphate products. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a solution of a soluble silicate, e.g. sodium silicate, and the combined liquids and solids are mixed to produce the flowable composition. Also provided are the compositions themselves as well as kits for preparing the same. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g. bone defects.

    摘要翻译： 提供生产可流动组合物的方法，例如 糊剂，即磷酸钙产品。 在本发明的方法中，将包含钙源和磷酸盐源的干燥反应物与可溶性硅酸盐的溶液合并。 并将混合的液体和固体混合以产生可流动的组合物。 还提供了组合物本身以及用于制备它们的试剂盒。 由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如， 骨缺损。