公开(公告)号：US4973585A

公开(公告)日：1990-11-27

申请号：US352675

申请日：1989-05-10

申请人： Gary A. Flynn ,  Douglas W. Beight

发明人： Gary A. Flynn ,  Douglas W. Beight

IPC分类号： C07K5/02

CPC分类号： C07K5/0222

摘要： This invention relates to derivatives of fused bicyclic or tricyclic lactams, to the intermediates and processes useful for their preparation and to their pharmacological effect in inhibiting the angiotensin converting enzyme and to their end-use application in the treatment of hypertension.

摘要翻译： 本发明涉及稠合双环或三环内酰胺衍生物，其中间体及其制备方法及其在抑制血管紧张素转化酶中的药理作用及其在高血压治疗中的最终用途。

公开(公告)号：US4824832A

公开(公告)日：1989-04-25

申请号：US139485

申请日：1987-12-30

申请人： Gary A. Flynn ,  Douglas W. Beight

发明人： Gary A. Flynn ,  Douglas W. Beight

IPC分类号： A61K31/55 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D471/04 ,  A61K31/33 ,  C07D223/10

CPC分类号： C07D471/04

摘要： This invention relates to conformationally rigid sulfur containing tricyclic lactams, to the intermediates and processes useful for their preparation, and to their pharmacological effects in inhibiting angiotensin converting enzyme, in treating reperfusion injury and in treating heart-failure.