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119 条记录 (耗时 0.027 秒)

    USE OF NORGESTIMATE AS A SELECTIVE INHIBITOR OF TRPC3, TRPC6 AND TRPC7 ION CHANNELS
    72.
    发明申请
    USE OF NORGESTIMATE AS A SELECTIVE INHIBITOR OF TRPC3, TRPC6 AND TRPC7 ION CHANNELS 失效
    作为TRPC3，TRPC6和TRPC7离子通道的选择性抑制剂的诺斯克公司的使用

    公开(公告)号：US20110015167A1

    公开(公告)日：2011-01-20

    申请号：US12738137

    申请日：2008-10-14

    申请人： Susanne Miehe ,  Heinz-Werner Kleemann ,  Carsten Struebing

    发明人： Susanne Miehe ,  Heinz-Werner Kleemann ,  Carsten Struebing

    IPC分类号： A61K31/567 ,  C12N5/071 ,  G01N33/567 ,  A61P9/10 ,  A61P25/00 ,  A61P13/12

    CPC分类号： A61K31/57 ,  G01N33/6872 ,  G01N2333/575 ,  G01N2500/10

    摘要： TRPC ion channels are non-selective channels widely expressed in human tissues. These channels are involved in numerous physiological functions and are putative targets for the development of novel medicines. There is a need to gain a better understanding of TRPC ion channels in cells and beyond. The present invention provides a pharmacological tool compound that allows to study TRPC ion channels due to its discriminating inhibition of TRPC subfamilies. In the present invention, norgestimate is shown to selectively inhibit TRPC3, TRPC6 and TRPC7.

    摘要翻译： TRPC离子通道是人组织中广泛表达的非选择性通道。 这些渠道涉及许多生理功能，是开发新型药物的推定目标。 需要更好地了解细胞中TRPC离子通道及其以外的信号。 本发明提供一种药理学工具化合物，由于其对TRPC亚家族的鉴别性抑制而允许研究TRPC离子通道。 在本发明中，诺孕酯被选择性地抑制TRPC3，TRPC6和TRPC7。

    Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
    73.
    发明授权
    Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them 失效
    五氟硫基苯基取代的苯甲酰胍，其制备方法，它们作为药物或诊断助剂的用途，以及包含它们的药物

    公开(公告)号：US07381841B2

    公开(公告)日：2008-06-03

    申请号：US10918902

    申请日：2004-08-16

    申请人： Heinz-Werner Kleemann

    发明人： Heinz-Werner Kleemann

    IPC分类号： C07C233/165 ,  A61K31/65

    CPC分类号： C07C381/00

    摘要： Pentafluorosulfany0lphenyl-substituted benzoylguanidines, process for their preparation, theie use as medicament or diagnostic aed, and medicament comprising them Pentafluorosulfany0lphenyl-substituted benzoylguanidines of the formulae I and II in which R1, R1′, R2, R2′, R3, R3′, R4 and X have the meanings indicated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.

    摘要翻译： 五氟硫烷基苯基取代的苯甲酰胍，其制备方法，用作药物或诊断方法，以及包含它们的式I和II的五氟硫烷基苯基取代的苯甲酰胍，其中R1，R1'，R2，R2'，R3，R3'，R4 和X具有权利要求中所示的含义，适合作为具有心脏保护成分的抗心律失常药物，用于预防梗死和治疗梗死和治疗心绞痛。 它们还预防性地抑制与缺血诱导的损伤的发展相关的病理生理过程，特别是在引发缺血诱发的心律失常中。

    Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same
    76.
    发明申请
    Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same 审中-公开
    五氟硫烷基苯甲酰胍，其制备方法，用作药物或诊断助剂，以及包含其的药物

    公开(公告)号：US20050124666A1

    公开(公告)日：2005-06-09

    申请号：US10989069

    申请日：2004-11-15

    申请人： Heinz-Werner Kleemann

    发明人： Heinz-Werner Kleemann

    IPC分类号： C07C381/00 ,  C07D213/63 ,  A61K31/4172 ,  A61K31/44

    CPC分类号： C07C381/00

    摘要： Pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings stated in the claims, are suitable, for example, as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.

    摘要翻译： 其中R 1至R 4具有权利要求中所述含义的式I的五氟硫烷基苯甲酰基胍适用于例如具有用于预防梗塞和治疗梗塞和用于治疗心绞痛的心脏保护组分的抗心律失常药物。 它们还预防性地抑制与缺血诱导的损伤的发展相关的病理生理过程，特别是在引发缺血诱发的心律失常中。

    Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
    78.
    发明申请
    Pentafluorosulfanylphenyl-substituted benzoylguanidines, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them 失效
    五氟硫基苯基取代的苯甲酰胍，其制备方法，它们作为药物或诊断助剂的用途，以及包含它们的药物

    公开(公告)号：US20050043401A1

    公开(公告)日：2005-02-24

    申请号：US10918902

    申请日：2004-08-16

    申请人： Heinz-Werner Kleemann

    发明人： Heinz-Werner Kleemann

    IPC分类号： C07C381/00 ,  C07C39/02 ,  A61K31/165 ,  A61K31/277

    CPC分类号： C07C381/00

    摘要： Pentafluorosulfanylphenyl-substituted benzoylguanidines of the formulae I and II in which R1, R1′, R2, R2′, R3, R3′, R4 and X have the meanings indicated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.

    摘要翻译： 其中R1，R1'，R2，R2'，R3，R3'，R4和X具有权利要求中所示含义的式I和II的五氟硫烷基苯基取代的苯甲酰基胍适合作为具有用于预防的心脏保护成分的抗心律失常药物 的梗死和治疗梗死和治疗心绞痛。 它们还预防性地抑制与缺血诱导的损伤的发展相关的病理生理过程，特别是在引发缺血诱发的心律失常中。