公开(公告)号：US20090202553A1

公开(公告)日：2009-08-13

申请号：US12230549

申请日：2008-08-29

申请人： Phillip R. Morrow ,  Angray S. Kang ,  Fei Wang ,  Ivy Jiang ,  Ritsuko Sawada ,  Wolfgang Scholz ,  Jeanne Morrow

发明人： Phillip R. Morrow ,  Angray S. Kang ,  Fei Wang ,  Ivy Jiang ,  Ritsuko Sawada ,  Wolfgang Scholz ,  Jeanne Morrow

IPC分类号： C07K16/12 ,  C12N15/13 ,  C12N15/85 ,  C12N5/10 ,  C12P21/08 ,  A61K39/40 ,  A61P31/04

CPC分类号： C07K16/1278 ,  A61K39/40 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

摘要： A highly efficient method for generating human antibodies using recall technology is provided. In one aspect, human antibodies which are specific to the anthrax toxin are provided. In one aspect, human peripheral blood cells that have been pre-exposed to anthrax toxin are used in the SCID mouse model. This method results in high human antibody titers which are primarily of the IgG isotype and which contain antibodies of high specificity and affinity to desired antigens. The antibodies generated by this method can be used therapeutically and prophylactically for preventing or treating mammals exposed to anthrax. Thus, in one embodiment, a prophylactic or therapeutic agent used to counter the effects of anthrax toxin, released as a mechanism of bioterrorism, is provided. In one embodiment, a formulation and method for preventing and/or treating anthrax infection comprising a binding agent that prevents the assembly of the PA63 heptamer is also provided. Methods for diagnosis and methods to determine anthrax contamination are also described.

摘要翻译： 提供了使用召回技术产生人抗体的高效方法。 一方面，提供了对炭疽毒素特异性的人抗体。 一方面，在SCID小鼠模型中使用预先暴露于炭疽毒素的人外周血细胞。 该方法导致高的人抗体滴度，其主要是IgG同种型，并且其含有对所需抗原具有高特异性和亲和力的抗体。 通过该方法产生的抗体可以治疗和预防用于预防或治疗暴露于炭疽的哺乳动物。 因此，在一个实施方案中，提供了用作抵抗作为生物恐怖机制的机制释放的炭疽毒素的作用的预防或治疗剂。 在一个实施方案中，还提供了用于预防和/或治疗炭疽感染的制剂和方法，其包含防止PA63七聚体组装的结合剂。 还描述了诊断方法和确定炭疽污染的方法。

公开(公告)号：US20090150107A1

公开(公告)日：2009-06-11

申请号：US12327833

申请日：2008-12-04

申请人： Wolfgang Scholz

发明人： Wolfgang Scholz

IPC分类号： G01P21/00 ,  G21C17/00

CPC分类号： F15B19/002 ,  Y10T137/2652 ,  Y10T137/3012 ,  Y10T137/538 ,  Y10T279/12 ,  Y10T279/1208

摘要： The disclosure relates to a method for commissioning pneumatically operated actuators that are controlled by a positioner. To determine the drive type, a constant flow of pneumatic fluid is applied to the actuator during commissioning while a drive-specific characteristic curve of the fed back position is recorded over time. Then the measured characteristic curve is compared with a given specimen characteristic curve. The drive type is inferred from the level of difference or agreement between the drive-specific characteristic curve and the specimen characteristic curve.

摘要翻译： 本公开涉及一种由定位器控制的用于调试气动操作致动器的方法。 为了确定驱动类型，在调试期间将恒定流量的气动流体施加到致动器，同时记录反馈位置的驱动特定曲线。 然后将测量的特征曲线与给定的样品特征曲线进行比较。 驱动类型根据驱动特性曲线和试样特性曲线之间的差异或一致性的水平推断。

公开(公告)号：US20080307889A1

公开(公告)日：2008-12-18

申请号：US11794679

申请日：2005-12-23

申请人： Wolfgang Scholz ,  Armin Gasch ,  Raiko Milanovic ,  Peter Riegler

发明人： Wolfgang Scholz ,  Armin Gasch ,  Raiko Milanovic ,  Peter Riegler

IPC分类号： G01L11/06

CPC分类号： G01L19/0092 ,  G01L19/0645 ,  G01L19/0672 ,  G01M3/24

摘要： The invention relates to a pressure sensor, the measuring cell of which is provided with at least one membrane for the protection of the pressure-sensitive element and a measuring chamber, filled with pressure medium, in which the pressure-sensitive element is housed. According to the invention, the membrane is monitored for damage, whereby at least one surface wave sensor is arranged in the chamber filled with pressure medium. On damage to the membrane occurring, process medium is mixed with the pressure medium. A substance change in the sensitive region of the surface wave sensor is thus brought about which results in a differing signal run time. Any change in run time is an indictor of damage to the pressure sensor and may be signaled as such.

摘要翻译： 本发明涉及一种压力传感器，其测量单元设置有用于保护压敏元件的至少一个膜和填充有压力介质的测量室，其中容纳压敏元件。 根据本发明，监测膜的损伤，由此在填充有压力介质的室中布置至少一个表面波传感器。 在发生膜的损坏时，将处理介质与压力介质混合。 因此，表面波传感器的敏感区域中的物质变化导致不同的信号运行时间。 运行时间的任何变化都是对压力传感器造成损害的指示器，并且可以这样发出信号。

公开(公告)号：US20080257428A1

公开(公告)日：2008-10-23

申请号：US12107856

申请日：2008-04-23

申请人： Wolfgang Scholz ,  Frank Marks

发明人： Wolfgang Scholz ,  Frank Marks

IPC分类号： F16K37/00 ,  G05B19/29 ,  G01B11/14

CPC分类号： G01D5/3473 ,  F16K31/126 ,  F16K37/0058 ,  Y10T137/8242

摘要： The disclosure relates to an actuating drive for control of an actuating element for automation in process installations. An exemplary actuating device drive for control of an actuating element comprising: a position detection device configured for detection of an actual position of the actuating element; a regulator unit configured for operational connection with the position detection device for comparison of an actual position with a predeterminable set position and for production of an actuating signal for driving the actuating drive, wherein the position detection device has a pattern support, at least part of whose surface is covered by a pattern which can be scanned optically; and a stationary optical scanning device, whose optical axis is aligned with the pattern.

摘要翻译： 本公开涉及用于控制用于过程装置中的自动化的致动元件的致动驱动器。 用于控制致动元件的示例性致动装置驱动器包括：位置检测装置，其被配置为检测致动元件的实际位置; 调节器单元，被配置为与所述位置检测装置的操作连接，用于将实际位置与可预定的设定位置进行比较，并且用于产生用于驱动所述致动驱动器的致动信号，其中所述位置检测装置具有图案支撑件，至少部分 其表面被可以被光学扫描的图案覆盖; 以及其光轴与图案对准的固定光学扫描装置。

公开(公告)号：US20080257054A1

公开(公告)日：2008-10-23

申请号：US11791948

申请日：2004-12-08

申请人： Sangkyun Kang ,  Wolfgang Scholz ,  Peter Krippner ,  Dieter Binz ,  Tibor Fabian ,  Fritz B. Prinz

发明人： Sangkyun Kang ,  Wolfgang Scholz ,  Peter Krippner ,  Dieter Binz ,  Tibor Fabian ,  Fritz B. Prinz

IPC分类号： G01L15/00

CPC分类号： G01L13/025 ,  G01L19/0046 ,  G01L19/0618 ,  G01L19/069

摘要： The disclosure relates to a differential pressure transducer unit comprising an over-load protection system which is used to measure low differential pressure in liquids and gases under high static pressure load which can be connected to flanges on the working pressure lines. The differential pressure transducer unit consists of a planar multi-layered arrangement comprising layers which are conductive, insulating and which are insulated from each other, whereby the insulating and conductive layers comprises recesses which at least partially cover each other, wherein the measuring mechanism and the measuring value processing means are accommodated. At least one of the layers is a functional component of the over-load protection system.

摘要翻译： 本公开涉及一种压差传感器单元，其包括过负载保护系统，其用于测量液体和气体在高静态压力负载下的低压差，该压力可连接到工作压力线上的凸缘。 压差传感器单元包括平面多层布置，其包括导电，绝缘并且彼此绝缘的层，由此绝缘和导电层包括至少部分地彼此覆盖的凹部，其中测量机构和 容纳测量值处理装置。 至少一层是过载保护系统的功能部件。

公开(公告)号：US20080081042A1

公开(公告)日：2008-04-03

申请号：US11041763

申请日：2005-01-24

申请人： Phillip R. Morrow ,  Angray S. Kang ,  Fei Wang ,  Ivy Jiang ,  Ritsuko Sawada ,  Wolfgang Scholz ,  Jeanne Morrow

发明人： Phillip R. Morrow ,  Angray S. Kang ,  Fei Wang ,  Ivy Jiang ,  Ritsuko Sawada ,  Wolfgang Scholz ,  Jeanne Morrow

IPC分类号： A61K39/40 ,  C07K16/12

CPC分类号： C07K16/1278 ,  A61K39/40 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

摘要： A highly efficient method for generating human antibodies using recall technology is provided. In one aspect, human antibodies which are specific to the anthrax toxin are provided. In one aspect, human peripheral blood cells that have been pre-exposed to anthrax toxin are used in the SCID mouse model. This method results in high human antibody titers which are primarily of the IgG isotype and which contain antibodies of high specificity and affinity to desired antigens. The antibodies generated by this method can be used therapeutically and prophylactically for preventing or treating mammals exposed to anthrax. Thus, in one embodiment, a prophylactic or therapeutic agent used to counter the effects of anthrax toxin, released as a mechanism of bioterrorism, is provided. In one embodiment, a formulation and method for preventing and/or treating anthrax infection comprising a binding agent that prevents the assembly of the PA63 heptamer is also provided. Methods for diagnosis and methods to determine anthrax contamination are also described.

摘要翻译： 提供了使用召回技术产生人抗体的高效方法。 一方面，提供了对炭疽毒素特异性的人抗体。 一方面，在SCID小鼠模型中使用预先暴露于炭疽毒素的人外周血细胞。 该方法导致高的人抗体滴度，其主要是IgG同种型，并且其含有对所需抗原具有高特异性和亲和力的抗体。 通过该方法产生的抗体可以治疗和预防用于预防或治疗暴露于炭疽的哺乳动物。 因此，在一个实施方案中，提供了用作抵抗作为生物恐怖机制的机制释放的炭疽毒素的作用的预防或治疗剂。 在一个实施方案中，还提供了用于预防和/或治疗炭疽感染的制剂和方法，其包含防止PA63七聚体组装的结合剂。 还描述了诊断方法和确定炭疽污染的方法。

公开(公告)号：US20070256329A1

公开(公告)日：2007-11-08

申请号：US11732831

申请日：2007-04-04

申请人： Bruno Antonelli ,  Wolfgang Scholz ,  Jurgen Weidl ,  Josh Gordon ,  Jan Hill ,  Gerd Manz

发明人： Bruno Antonelli ,  Wolfgang Scholz ,  Jurgen Weidl ,  Josh Gordon ,  Jan Hill ,  Gerd Manz

IPC分类号： A43B13/42 ,  A43B23/10

CPC分类号： A43B5/02 ,  A43B1/0009 ,  A43B1/0072 ,  A43B5/025 ,  A43B5/06 ,  A43B13/186 ,  A43B13/188 ,  A43B23/08

摘要： The invention relates to a shoe having a sole element. The sole element includes a sole area extending below a wearer's foot and a heel cup three-dimensionally encompassing a heel of the wearer's foot. The heel cup alone forms at least a portion of a sidewall of the shoe.

摘要翻译： 本发明涉及具有唯一元件的鞋。 唯一的元件包括在佩戴者的脚下方延伸的鞋底区域和三维地包围穿着者的脚跟的脚后跟杯。 脚跟杯单独形成鞋的侧壁的至少一部分。

公开(公告)号：US20070022633A1

公开(公告)日：2007-02-01

申请号：US11541825

申请日：2006-10-02

申请人： Roland Seydel ,  Wolfgang Scholz

发明人： Roland Seydel ,  Wolfgang Scholz

IPC分类号： A43B5/02 ,  A43B5/00

CPC分类号： A43B7/1455 ,  A43B5/02 ,  A43B13/14 ,  A43B19/005 ,  A43C13/02 ,  A43C15/16

摘要： Disclosed is a shoe including an upper for receiving a foot and a sole unit with a heel region and forefoot region, wherein an additional weight is arranged in at least one of the forefoot region and the heel region of the sole unit to stabilize the foot against at least one torque acting on a wearer's foot.

摘要翻译： 公开了一种鞋，其包括用于接收脚的鞋面和具有脚后跟区域和前脚区域的鞋底单元，其中，在鞋底单元的前脚掌区域和脚后跟区域中的至少一个中布置附加重量，以使鞋脚抵抗 至少一个作用在使用者脚上的扭矩。

公开(公告)号：US20050281830A1

公开(公告)日：2005-12-22

申请号：US11041471

申请日：2005-01-24

申请人： Phillip Morrow ,  Jeanne Morrow ,  Angray Kang ,  Fei Wang ,  Ivy Jiang ,  Ritsuko Sawada ,  Wolfgang Scholz

发明人： Phillip Morrow ,  Jeanne Morrow ,  Angray Kang ,  Fei Wang ,  Ivy Jiang ,  Ritsuko Sawada ,  Wolfgang Scholz

IPC分类号： A61K39/40 ,  G01N33/554 ,  G01N33/569

CPC分类号： G01N33/6854 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1278 ,  C07K2317/21 ,  G01N2333/35 ,  A61K2300/00

摘要： A highly efficient method for generating human antibodies using recall technology is provided. In one aspect, human antibodies which are specific to the anthrax toxin are provided. In one aspect, human peripheral blood cells that have been pre-exposed to anthrax toxin are used in the SCID mouse model. This method results in high human antibody titers which are primarily of the IgG isotype and which contain antibodies of high specificity and affinity to desired antigens. The antibodies generated by this method can be used therapeutically and prophylactically for preventing or treating mammals exposed to anthrax. Thus, in one embodiment, a prophylactic or therapeutic agent used to counter the effects of anthrax toxin, released as a mechanism of bioterrorism, is provided. In one embodiment, a formulation and method for preventing and/or treating anthrax infection comprising a binding agent that prevents the assembly of the PA63 heptamer is also provided. Methods for diagnosis and methods to determine anthrax contamination are also described.

摘要翻译： 提供了使用召回技术产生人抗体的高效方法。 一方面，提供了对炭疽毒素特异性的人抗体。 一方面，在SCID小鼠模型中使用预先暴露于炭疽毒素的人外周血细胞。 该方法导致高的人抗体滴度，其主要是IgG同种型，并且其含有对所需抗原具有高特异性和亲和力的抗体。 通过该方法产生的抗体可以治疗和预防用于预防或治疗暴露于炭疽的哺乳动物。 因此，在一个实施方案中，提供了用作抵抗作为生物恐怖机制的机制释放的炭疽毒素的作用的预防或治疗剂。 在一个实施方案中，还提供了用于预防和/或治疗炭疽感染的制剂和方法，其包含防止PA63七聚体组装的结合剂。 还描述了诊断方法和确定炭疽污染的方法。

公开(公告)号：US20050183514A1

公开(公告)日：2005-08-25

申请号：US10958372

申请日：2004-10-06

申请人： Dirk Huybrechts ,  Hans-Werner Schwiderski ,  Gunter Rasche ,  Arno Oehler ,  Dieter Keese ,  Dominik Eifel ,  Eniet Asaah ,  Andreas Thone ,  Ralf Huck ,  Wolfgang Scholz ,  Fabrizio Lorito ,  Albrecht Vogel ,  Paul Szasz

发明人： Dirk Huybrechts ,  Hans-Werner Schwiderski ,  Gunter Rasche ,  Arno Oehler ,  Dieter Keese ,  Dominik Eifel ,  Eniet Asaah ,  Andreas Thone ,  Ralf Huck ,  Wolfgang Scholz ,  Fabrizio Lorito ,  Albrecht Vogel ,  Paul Szasz

IPC分类号： G01F1/58 ,  G02B6/00

CPC分类号： G01F15/006 ,  G01F1/588

摘要： The invention relates to a magnetic-inductive measuring device (1) for flowing substances (substance being measured), with at least one subsystem respectively for carrying substance (hydraulic system, measuring tube) (2), for recording measuring signals, comprising a signal pickup (electrode arrangement (20, 22) for signal tapping), for generating a magnetic field, comprising at least two exciting coils (30) and a ferromagnetic core (32) (magnetic system), and for bounding the device on the ambient side (housing), and is characterized in that at least one of the subsystems is entirely or partly formed by layers of fibre composite material and/or is embedded in layers of fibre composite material.

摘要翻译： 本发明涉及一种用于使物质（被测量物质）流动的磁感应测量装置（1），其中至少一个子系统用于承载物质（液压系统，测量管）（2），用于记录测量信号，包括信号 拾取（用于信号分接的电极布置（20,22）），用于产生包括至少两个励磁线圈（30）和铁磁芯（32）（磁性系统））的磁场，并且用于将环境侧的装置 （壳体），其特征在于至少一个子系统由纤维复合材料层完全或部分地形成和/或嵌入在纤维复合材料层中。