公开(公告)号：US20060183683A1

公开(公告)日：2006-08-17

申请号：US11304429

申请日：2005-12-15

申请人： Birthe Hansen ,  Michael Jensen ,  Troels Kornfelt

发明人： Birthe Hansen ,  Michael Jensen ,  Troels Kornfelt

IPC分类号： A61K38/36 ,  A61K31/19

CPC分类号： A61K47/02 ,  A61K9/0019 ,  A61K31/19 ,  A61K47/183

摘要： The invention concerns a liquid aqueous composition comprising (i) a factor VII polypeptide, (ii) an agent suitable for keeping pH in the range of from about 4.0 to about 9.0; (iii) an agent selected from the group consisting of: a calcium salt, a magnesium salt, or a mixture thereof; wherein the concentration of (iii) is less than 15 mM; and (iv) An ionic strength modifying agent; wherein the ionic strength of the composition is at least 200 mM.

摘要翻译： 本发明涉及一种液体含水组合物，其包含（i）因子VII多肽，（ii）适于将pH保持在约4.0至约9.0范围内的试剂; （iii）选自以下的试剂：钙盐，镁盐或其混合物; 其中（iii）的浓度小于15mM; 和（iv）离子强度改性剂; 其中所述组合物的离子强度为至少200mM。

公开(公告)号：US20060179276A1

公开(公告)日：2006-08-10

申请号：US11087063

申请日：2005-03-22

申请人： Soumya Banerjee ,  Michael Jensen

发明人： Soumya Banerjee ,  Michael Jensen

IPC分类号： G06F9/40

CPC分类号： G06F9/3851 ,  G06F9/3802 ,  G06F9/3814

摘要： A fetch director in a multithreaded microprocessor that concurrently executes instructions of N threads is disclosed. The N threads request to fetch instructions from an instruction cache. In a given selection cycle, some of the threads may not be requesting to fetch instructions. The fetch director includes a circuit for selecting one of threads in a round-robin fashion to provide its fetch address to the instruction cache. The circuit 1-bit left rotatively increments a first addend by a second addend to generate a sum that is ANDed with the inverse of the first addend to generate a 1-hot vector indicating which of the threads is selected next. The first addend is an N-bit vector where each bit is false if the corresponding thread is requesting to fetch instructions from the instruction cache. The second addend is a 1-hot vector indicating the last selected thread. In one embodiment threads with an empty instruction buffer are selected at highest priority; a last dispatched but not fetched thread at middle priority; all other threads at lowest priority. The threads are selected round-robin within the highest and lowest priorities.

摘要翻译： 公开了并行执行N线程指令的多线程微处理器中的提取指导者。 N线程请求从指令高速缓存获取指令。 在给定的选择周期中，某些线程可能没有请求获取指令。 提取指导器包括用于以循环方式选择线程之一以将其提取地址提供给指令高速缓存的电路。 1位左电路通过第二加数旋转地增加第一加数，以产生与第一加数的反相并联的和，以产生指示下一个选择的线程的1-hot向量。 第一个加数是一个N位向量，如果相应的线程请求从指令高速缓存中获取指令，则每个位都为假。 第二个加法是指示最后选择的线程的1-hot向量。 在一个实施例中，以最高优先级选择具有空指令缓冲器的线程; 中间优先级的最后发送但未获取的线程; 所有其他线程的优先级最低。 线程在最高和最低优先级内选择循环。

公开(公告)号：US20060179194A1

公开(公告)日：2006-08-10

申请号：US11087064

申请日：2005-03-22

申请人： Michael Jensen

发明人： Michael Jensen

IPC分类号： G06F13/00

CPC分类号： G06F9/3851 ,  G06F7/5055 ,  G06F9/30079 ,  G06F9/30087 ,  G06F9/3009 ,  G06F9/3802 ,  G06F9/3814 ,  G06F9/3836 ,  G06F9/3838 ,  G06F9/3857 ,  G06F9/3859 ,  G06F9/3861 ,  G06F9/3867

摘要： A circuit for selecting one of N requestors in a round-robin fashion is disclosed. The circuit 1-bit left rotatively increments a first addend by a second addend to generate a sum that is ANDed with the inverse of the first addend to generate a 1-hot vector indicating which of the requestors is selected next. The first addend is an N-bit vector where each bit is false if the corresponding requester is requesting access to a shared resource. The second addend is a 1-hot vector indicating the last selected requester. A multithreading microprocessor dispatch scheduler employs the circuit for N concurrent threads each thread having one of P priorities. The dispatch scheduler generates P N-bit 1-hot round-robin bit vectors, and each thread's priority is used to select the appropriate round-robin bit from P vectors for combination with the thread's priority and an issuable bit to create a dispatch level used to select a thread for instruction dispatching.

公开(公告)号：US20060138000A1

公开(公告)日：2006-06-29

申请号：US11024292

申请日：2004-12-23

申请人： Michael Jensen ,  Michel Arney ,  Alexandre Hennen ,  Ann Sullivan

发明人： Michael Jensen ,  Michel Arney ,  Alexandre Hennen ,  Ann Sullivan

IPC分类号： B65D85/30

CPC分类号： G11B33/0444

摘要： A foldable compact disc case for retaining multiple compact discs to the visor of the vehicle. The foldable compact disc visor case is adapted to be connected to a vehicle visor and includes a foldable body having a first body portion and a second body portion, each portion being interconnected by a hinge. The foldable body is adapted to be retained to a vehicle visor by the use of elastomeric straps that are secured around the perimeter of the visor. The foldable body includes a plurality of pockets located on both the first and second body portions for retaining compact discs. The foldable body further includes a page hingedly connected to the foldable body between the first and second body portions. The page includes a plurality of pockets on both sides for retaining compact discs and includes a plurality of fasteners to permit the page to be selectively attached adjacent either the first body portion or the second body portion so that compact discs can be removed from the foldable compact disc case without the need for the driver to retain the position of the page while removing the discs.

摘要翻译： 一种可折叠的光盘盒，用于将多个光盘保持在车辆的遮阳板上。 可折叠的光盘遮阳板壳体适于连接到车辆遮阳板，并且包括具有第一主体部分和第二主体部分的可折叠主体，每个部分通过铰链互连。 可折叠体适于通过使用固定在遮阳板周边的弹性带固定在车辆遮阳板上。 可折叠体包括位于第一和第二主体部分上的用于保持光盘的多个凹穴。 折叠体还包括在第一和第二主体部分之间铰接地连接到可折叠主体的页面。 页面包括在两侧的多个凹口用于保持紧凑的光盘并且包括多个紧固件，以允许页面被选择性地附接在第一主体部分或第二主体部分附近，使得光盘可从可折叠的紧凑件 光盘盒，而不需要驱动程序在移除光盘的同时保留页面的位置。

公开(公告)号：US20050129671A1

公开(公告)日：2005-06-16

申请号：US10797609

申请日：2004-03-11

申请人： Laurence Cooper ,  Michael Jensen

发明人： Laurence Cooper ,  Michael Jensen

IPC分类号： A61K39/00 ,  A61K48/00 ,  C12N5/0783 ,  C12N5/08

CPC分类号： A61K35/12 ,  A61K35/17 ,  A61K39/0011 ,  A61K39/145 ,  A61K39/245 ,  A61K2039/5158 ,  C12N5/0636

摘要： The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to viral specific T cells that express chimeric anti-tumor receptors. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.

摘要翻译： 本发明涉及哺乳动物双特异性T细胞和使用这些双特异性T细胞的方法。 更具体地，本发明涉及表达嵌合抗肿瘤受体的病毒特异性T细胞。 这些双特异性T细胞克隆是效应细胞的来源，其在体内依赖于用病毒抗原的刺激而持续存在，导致其转移到患有癌症和自身免疫疾病的患者之后的长期功能。

公开(公告)号：US06693557B2

公开(公告)日：2004-02-17

申请号：US09964668

申请日：2001-09-27

申请人： David V. Arnold ,  Logan Harris ,  Michael Jensen ,  Thomas William Karlinsey ,  Ryan Smith ,  Jonathan L. Waite ,  John B. Dougall, Jr.

发明人： David V. Arnold ,  Logan Harris ,  Michael Jensen ,  Thomas William Karlinsey ,  Ryan Smith ,  Jonathan L. Waite ,  John B. Dougall, Jr.

IPC分类号： G08G101

CPC分类号： H01Q21/0006 ,  G01S7/032 ,  G01S7/352 ,  G01S13/04 ,  G01S13/34 ,  G08G1/042 ,  H01Q13/106 ,  H01Q21/08

摘要： A vehicle traffic sensor for detecting and monitoring vehicular targets is presented. The sensor employs a planar design resulting in a reduced profile sensor. The sensor includes a multi-layer radio frequency board with RF components on one of the sides and both isolation and planar array antennas on the opposing side. The antennas are preferably tapered planar array antennas which include one transmit antenna and one receive antenna. The sensor also includes at least one logic or signal processing board populated with components on a first side and a ground plane on a second side positioned toward the RF componentry of the RF board to form an RF shield. The boards are housed within a housing that is permeable, at least on the side through which the antenna structures propagate.

摘要翻译： 提出了一种用于检测和监控车辆目标的车辆交通传感器。 该传感器采用平面设计，从而减少轮廓传感器。 该传感器包括在其一侧具有RF部件的多层射频板以及相对侧的隔离和平面阵列天线。 天线优选是包括一个发射天线和一个接收天线的锥形平面阵列天线。 该传感器还包括至少一个逻辑或信号处理板，其填充有第一侧上的部件和位于RF板的RF部件的第二侧上的接地平面，以形成RF屏蔽。 板被容纳在可透气的壳体内，至少在天线结构传播的一侧。

公开(公告)号：US09217026B2

公开(公告)日：2015-12-22

申请号：US11983888

申请日：2007-11-13

申请人： Andreas Reik ,  Michael Jensen ,  Michael C. Holmes ,  Philip D. Gregory ,  Dale Ando

发明人： Andreas Reik ,  Michael Jensen ,  Michael C. Holmes ,  Philip D. Gregory ,  Dale Ando

IPC分类号： C07K14/72 ,  C12N15/62

CPC分类号： C12N15/86 ,  C07K14/721 ,  C12N9/22 ,  C12N15/62 ,  C12N2710/10043 ,  C12N2740/15043 ,  G01N33/743 ,  G01N2333/723

摘要： Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

摘要翻译： 本文公开了通过靶向切割编码GR的基因组DNA来灭活人类糖皮质激素受体（GR）基因的方法和组合物。 这些方法和组合物可用于例如在糖皮质激素治疗期间需要保留免疫功能的治疗应用中。

公开(公告)号：US09160170B2

公开(公告)日：2015-10-13

申请号：US13356871

申请日：2012-01-24

申请人： Kim Hoej Jensen ,  Michael Jensen

发明人： Kim Hoej Jensen ,  Michael Jensen

IPC分类号： H01H9/54 ,  H01H85/46 ,  H01H35/00 ,  H02J3/46 ,  H02P9/00 ,  G05D3/12 ,  H02J3/24 ,  H02J3/01 ,  H02J3/38

CPC分类号： H02J3/24 ,  H02J3/01 ,  H02J3/386 ,  Y02E10/725 ,  Y02E10/763 ,  Y02E40/40 ,  Y10T307/718

摘要： A power generator park provided, which includes at least two power generator devices. Each power generator device has a switching converter for providing an electrical output power. A central controller is provided for providing switching parameter settings to the switching converters. Each of the at least two power generator devices further includes a timing unit for receiving a common time signal. The switching converter of each of the at least two power generator devices is configured for controlling at least one switching parameter in response to the respective switching parameter setting with a temporal coordination based on the common time signal.

摘要翻译： 提供了一个发电机园，其包括至少两个发电机装置。 每个发电机装置具有用于提供电输出功率的开关转换器。 提供了一种中央控制器，用于向开关转换器提供开关参数设置。 所述至少两个发电机装置中的每一个还包括用于接收公共时间信号的定时单元。 所述至少两个发电机装置中的每一个的开关转换器被配置为响应于基于公共时间信号的时间协调来响应于相应的开关参数设置来控制至少一个开关参数。

公开(公告)号：US08497118B2

公开(公告)日：2013-07-30

申请号：US13570032

申请日：2012-08-08

申请人： Michael Jensen

发明人： Michael Jensen

IPC分类号： C12N15/63 ,  C07H21/04 ,  C07K16/46 ,  C07K19/00

CPC分类号： A61K38/2086 ,  A61K35/17 ,  A61K38/1774 ,  C07H21/04 ,  C07K14/5437 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/7155 ,  C07K16/46 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/30 ,  C12N5/0636 ,  C12N15/63

摘要： The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signalling domain. Zetakines, when expressed on the surface of T lymphocytes, direct T cell activity to those specific cells expressing a receptor for which the soluble receptor ligand is specific. Zetakine chimeric immunoreceptors represent a novel extension of antibody-based immunoreceptors for redirecting the antigen specificity of T cells, with application to treatment of a variety of cancers, particularly via the autocrin/paracrine cytokine systems utilized by human maligancy. In a preferred embodiment is a glioma-specific immunoreceptor comprising the extracellular targetting domain of the IL-13Rα2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.

公开(公告)号：US20120193991A1

公开(公告)日：2012-08-02

申请号：US13356871

申请日：2012-01-24

申请人： Kim Hoej Jensen ,  Michael Jensen

发明人： Kim Hoej Jensen ,  Michael Jensen

IPC分类号： H02J3/00

CPC分类号： H02J3/24 ,  H02J3/01 ,  H02J3/386 ,  Y02E10/725 ,  Y02E10/763 ,  Y02E40/40 ,  Y10T307/718

摘要： A power generator park provided, which includes at least two power generator devices. Each power generator device has a switching converter for providing an electrical output power. A central controller is provided for providing switching parameter settings to the switching converters. Each of the at least two power generator devices further includes a timing unit for receiving a common time signal. The switching converter of each of the at least two power generator devices is configured for controlling at least one switching parameter in response to the respective switching parameter setting with a temporal coordination based on the common time signal.

摘要翻译： 提供了一个发电机园，其包括至少两个发电机装置。 每个发电机装置具有用于提供电输出功率的开关转换器。 提供了一种中央控制器，用于向开关转换器提供开关参数设置。 所述至少两个发电机装置中的每一个还包括用于接收公共时间信号的定时单元。 所述至少两个发电机装置中的每一个的开关转换器被配置为响应于基于公共时间信号的时间协调来响应于相应的开关参数设置来控制至少一个开关参数。