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71.
公开(公告)号:US5401745A
公开(公告)日:1995-03-28
申请号:US33595
申请日:1993-03-19
申请人: Scott W. Bagley , Prasun K. Chakravarty , Anna Chen , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Elizabeth M. Naylor , James R. Tata , Thomas F. Walsh , David L. Williams, Jr.
发明人: Scott W. Bagley , Prasun K. Chakravarty , Anna Chen , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Elizabeth M. Naylor , James R. Tata , Thomas F. Walsh , David L. Williams, Jr.
IPC分类号: C07D239/91 , C07D405/12 , A61K31/505 , A61K31/54 , C07D239/86 , C07D239/95
CPC分类号: C07D405/12 , C07D239/91
摘要: Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebal and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.
摘要翻译: 苯氧基苯基乙酸和一般结构式I的衍生物具有内皮素拮抗剂活性,因此可用于治疗心血管疾病,例如高血压,缺血性肾衰竭,血管痉挛,脑和心脏缺血,心肌梗死,炎性疾病,雷诺氏病, 和内毒素性休克和哮喘。
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72.Substituted imidazo-fused 5-membered ring heterocycles as angiotensin II antagonists 失效
标题翻译: 取代的咪唑稠合的5元环杂环作为血管紧张素II拮抗剂公开(公告)号:US5389660A
公开(公告)日:1995-02-14
申请号:US957588
申请日:1992-10-07
申请人: William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
发明人: William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
IPC分类号: A61K31/415 , A61K31/42 , A61K31/425 , A61P9/08 , A61P9/10 , A61P9/12 , A61P27/02 , A61P43/00 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D521/00 , C07F9/6561 , A61K31/41 , C07D487/02
CPC分类号: C07D487/04 , C07D491/04 , C07D495/04
摘要: There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula: ##STR1##
摘要翻译: 公开了可用作血管紧张素II拮抗剂的新的取代的咪唑并稠合的5元环杂环化合物及其衍生物。 这些化合物具有通式:(I)
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73.Substituted pyridopyrimidinones and related heterocycles as angiotensin II antagonists 失效
标题翻译: 取代的吡啶并嘧啶酮和相关杂环作为血管紧张素II拮抗剂公开(公告)号:US5330987A
公开(公告)日:1994-07-19
申请号:US894036
申请日:1992-06-04
申请人: Eric E. Allen , Prasun K. Chakravarty , Stephen E. de Laszlo , William J. Greenlee , Arthur A. Patchett , Thomas F. Walsh
发明人: Eric E. Allen , Prasun K. Chakravarty , Stephen E. de Laszlo , William J. Greenlee , Arthur A. Patchett , Thomas F. Walsh
IPC分类号: A61K31/505 , A61P9/00 , A61P9/12 , C07D471/04 , C07D403/12 , C07D487/04
CPC分类号: C07D471/04
摘要: Novel substituted pyridopyrimidinones of formula (I), which are useful as angiotensin II antagonists, are disclosed. ##STR1##
摘要翻译: 公开了可用作血管紧张素II拮抗剂的式(I)的新型取代的吡啶并嘧啶酮。 (一)
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74.Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element 失效
标题翻译: 喹唑啉酮,三唑啉酮和包含取代的苄基元素的嘧啶酮血管紧张素II拮抗剂公开(公告)号:US5264439A
公开(公告)日:1993-11-23
申请号:US744138
申请日:1991-08-13
申请人: William J. Greenlee , David Hangauer , Arthur A. Patchett , Thomas F. Walsh , Kenneth J. Fitch , Daljit S. Dhanoa , Ralph A. Rivero
发明人: William J. Greenlee , David Hangauer , Arthur A. Patchett , Thomas F. Walsh , Kenneth J. Fitch , Daljit S. Dhanoa , Ralph A. Rivero
IPC分类号: C07D235/08 , C07D239/36 , C07D239/91 , C07D249/12 , C07D471/04 , A61K31/505 , C07D239/90
CPC分类号: C07D471/04 , C07D235/08 , C07D239/36 , C07D239/91 , C07D249/12
摘要: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##
摘要翻译: 通过亚甲基桥连接到式I的新的取代的苯基衍生物的取代的杂环可用作血管紧张素II拮抗剂。
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75.
公开(公告)号:US5250521A
公开(公告)日:1993-10-05
申请号:US794533
申请日:1991-11-25
申请人: Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Malcolm MacCoss , Arthur A. Patchett , Thomas F. Walsh
发明人: Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Malcolm MacCoss , Arthur A. Patchett , Thomas F. Walsh
IPC分类号: C07D487/04 , A61K31/505 , A61K31/535 , A61K31/54
CPC分类号: C07D487/04
摘要: Novel substituted pyrazolopyrimidines of formula (I) which are useful as angiotensin II antagonists, are disclosed. ##STR1##
摘要翻译: 公开了用作血管紧张素II拮抗剂的式(I)的新型取代吡唑并嘧啶。 (一)
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76.Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring 失效
标题翻译: 掺入取代吡啶并咪唑环的血管紧张素II拮抗剂公开(公告)号:US5240938A
公开(公告)日:1993-08-31
申请号:US744557
申请日:1991-08-13
申请人: William J. Greenlee , Arthur A. Patchett , David Hangauer , Thomas F. Walsh , Kenneth J. Fitch , Ralph A. Rivero , Daljit S. Dhanoa
发明人: William J. Greenlee , Arthur A. Patchett , David Hangauer , Thomas F. Walsh , Kenneth J. Fitch , Ralph A. Rivero , Daljit S. Dhanoa
IPC分类号: A61K31/44 , C07D471/04 , C07D491/048
CPC分类号: C07D471/04 , A61K31/44
摘要: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##
摘要翻译: 通过亚甲基桥连接到式I的新的取代的苯基衍生物的取代的杂环可用作血管紧张素II拮抗剂。
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77.Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin II antagonsists 失效
标题翻译: 取代的IMIDAZO-FUSED 5结构环杂交体及其作为ANGIOTENSIN II拮抗剂的使用公开(公告)号:US5164407A
公开(公告)日:1992-11-17
申请号:US516502
申请日:1990-04-25
申请人: William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
发明人: William J. Greenlee , David B. R. Johnston , Malcolm MacCoss , Nathan B. Mantlo , Arthur A. Patchett , Prasun K. Chakravarty , Thomas F. Walsh
IPC分类号: A61K31/415 , A61K31/42 , A61K31/425 , A61P9/08 , A61P9/10 , A61P9/12 , A61P27/02 , A61P43/00 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D521/00 , C07F9/6561
CPC分类号: C07D487/04 , C07D491/04 , C07D495/04
摘要: There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula: ##STR1##
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78.
公开(公告)号:US5100897A
公开(公告)日:1992-03-31
申请号:US550951
申请日:1990-07-16
申请人: Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Arthur A. Patchett , Thomas F. Walsh
发明人: Eric E. Allen , William J. Greenlee , Prasun K. Chakravarty , Arthur A. Patchett , Thomas F. Walsh
IPC分类号: A61K31/505 , A61P9/12 , A61P27/02 , C07D239/36 , C07D239/42 , C07D239/52 , C07D403/10 , C07D403/12 , C07F9/46
CPC分类号: C07D239/36 , C07D239/52 , C07D403/10
摘要: Novel substituted pyrimidinones of formula (I) which are useful as angiotensin II antagonists, are disclosed. ##STR1##
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