公开(公告)号：US20050260722A1

公开(公告)日：2005-11-24

申请号：US10606302

申请日：2003-06-25

申请人： Danilo Porro ,  Michael Sauer

发明人： Danilo Porro ,  Michael Sauer

IPC分类号： C12N15/09 ,  C12N1/19 ,  C12N9/02 ,  C12N9/04 ,  C12N9/18 ,  C12N15/52 ,  C12N15/53 ,  C12N15/55 ,  C12P17/04 ,  C12R1/645 ,  C12N1/18

CPC分类号： C12N9/001 ,  C12N9/0006 ,  C12N9/18 ,  C12N15/52 ,  C12P17/04

摘要： Herein is disclosed a method of generating ascorbic acid from yeast. In one embodiment, the yeast is a Zygosaccharomyces spp. or a Kluyveromyces spp. growing in a medium comprising an ascorbic acid precursor. In a second embodiment the yeast is a recombinant yeast growing in a medium comprising an ascorbic acid precursor. Preferably the recombinant yeast is transformed with a coding region encoding an enzyme selected from L-galactose dehydrogenase (LGDH), L-galactono-1,4-lactone dehydrogenase (AGD), D-arabinose dehydrogenase (ARA), D-arabinono-1,4-lactone oxidase (ALO) or L-gulono-1,4-lactone oxidase (RGLO). The ascorbic acid precursor is preferably D-glucose, L-galactose, L-galactono-1,4-lactone, or L-gulono-1,4-lactone. In another preferred embodiment the ascorbic acid is accumulated in the medium at levels greater than background. Preferably, the yield of the conversion of the precursor to ascorbic acid is preferably at least about 35%.

摘要翻译： 本文公开了从酵母产生抗坏血酸的方法。 在一个实施方案中，酵母是接合酵母属（Zygosaccharomyces spp）。 或克鲁维链霉菌属 在包含抗坏血酸前体的培养基中生长。 在第二个实施方案中，酵母是在包含抗坏血酸前体的培养基中生长的重组酵母。 优选地，用编码选自L-半乳糖脱氢酶（LGDH），L-半乳糖内酰-1,4-内酯脱氢酶（AGD），D-阿拉伯糖脱氢酶（ARA），D-阿拉伯聚糖-1 ，4-内酯氧化酶（ALO）或L-古洛酮-1,4-内酯氧化酶（RGLO）。 抗坏血酸前体优选为D-葡萄糖，L-半乳糖，L-半乳糖-1,4-内酯或L-古洛宁-1,4-内酯。 在另一个优选的实施方案中，抗坏血酸以大于背景的水平积累在培养基中。 优选地，前体转化成抗坏血酸的产率优选至少为约35％。

公开(公告)号：US06129392A

公开(公告)日：2000-10-10

申请号：US945006

申请日：1997-12-26

申请人： Horst Dittrich ,  Uwe Bacher ,  Michael Sauer

发明人： Horst Dittrich ,  Uwe Bacher ,  Michael Sauer

IPC分类号： A61B1/00 ,  A61B17/00 ,  F16L37/18

CPC分类号： A61B1/00128 ,  A61B17/00 ,  A61B2017/00477

摘要： A coupling assembly for connecting a handle to an instrument extending along a longitudinal axis has a coupler, which releasably receives the handle and has an outer sleeve and a snap-in sleeve formed with a snap-in element. The handle has a recess receiving the snap-in element which is guided along a conical recess formed in the outer sleeve to move to a locking position wherein the handle and the coupler are displaceably fixed relative each other. The outer sleeve is rotatable about the longitudinal axis and its recess has a periphery formed with an inner surface enabling the snap-in element to move radially from the locking position during rotation so as the handle can be axially withdrawn from the coupler.

摘要翻译： PCT No.PCT / DE96 / 00650 Sec。 371 1997年12月26日第 102（e）日期1997年12月26日PCT提交1996年4月15日PCT公布。 出版物WO96 / 32068 PCT 日期1996年10月17日用于将手柄连接到沿着纵向轴线延伸的器械的联接组件具有联接器，该联接器可释放地容纳手柄并具有外套筒和形成有卡扣元件的卡入套筒。 手柄具有接收卡扣元件的凹部，其沿着形成在外套筒中的锥形凹部被引导以移动到锁定位置，其中手柄和联接器可相对于彼此可位移地固定。 外套筒可以围绕纵向轴线旋转，并且其凹部具有形成有内表面的周边，使得卡扣元件能够在旋转期间从锁定位置径向移动，从而可以将手柄从联接器轴向拉出。

公开(公告)号：US5993402A

公开(公告)日：1999-11-30

申请号：US958354

申请日：1997-10-27

申请人： Michael Sauer ,  Norbert Schaefer

发明人： Michael Sauer ,  Norbert Schaefer

IPC分类号： A61C1/00 ,  A61C17/02 ,  A61H9/00

CPC分类号： A61C17/02 ,  A61C1/0092

摘要： The invention is directed to an oral irrigator for the care and cleaning of teeth and gums, which is provided with a pump (1) adapted to be driven by an electric motor. The pump (1) has an inlet (2) connected in particular to a liquid reservoir and provided with an inlet valve (8), an outlet (3) connected in particular to a jet nozzle and provided with an outlet valve (21), as well as a pump cylinder (5) connected to the inlet (2) and the outlet (3). The pump cylinder (5) has a piston (4) reciprocating therein, whereby liquid can be drawn from the inlet (2) into the pump cylinder (5) following which the drawn liquid can be delivered from the pump cylinder (5) to the outlet (3). The inlet valve (8) includes a pressure relief valve (13) through which liquid can be delivered from the pump cylinder (5) to the inlet (2) in the event of excess pressure building up. It is thus sufficient to provide on the jet nozzle only a shut-off valve (25) for shutting off the water pumped to the jet nozzle. It is not necessary for the electric on-off switch of the pump (1) to be located on the jet nozzle, but it may be disposed on the housing of the oral irrigator.

摘要翻译： 本发明涉及一种用于护理和清洁牙齿和牙龈的口腔冲洗器，其具有适于由电动机驱动的泵（1）。 泵（1）具有特别连接到液体储存器的入口（2），其具有入口阀（8），特别地连接到喷嘴并具有出口阀（21）的出口（3） 以及连接到入口（2）和出口（3）的泵筒（5）。 泵缸（5）具有在其中往复运动的活塞（4），从而可将液体从入口（2）抽出到泵缸（5）中，随后将抽出的液体从泵缸（5）输送到 出口（3）。 入口阀（8）包括压力释放阀（13），在压力过大的情况下，液体可以通过该泄压阀从泵缸（5）输送到入口（2）。 因此，仅在喷嘴上设置截止阀（25）就可以关闭泵送到喷嘴的水。 泵（1）的电动开关不需​​要位于喷嘴上，而是可以设置在口腔冲洗器的外壳上。

公开(公告)号：US10575870B2

公开(公告)日：2020-03-03

申请号：US11971536

申请日：2008-01-09

申请人： Sascha Berberich ,  Sebastian Frey ,  Michael Sauer

发明人： Sascha Berberich ,  Sebastian Frey ,  Michael Sauer

IPC分类号： A61B1/00 ,  A61B17/34

摘要： The invention relates to a surgical instrument system, which comprises a hollow shaft as well as a shaft-type instrument that can be inserted into the hollow shaft. To create a surgical instrument system that consists of a hollow shaft and of a medical instrument that can be inserted into the hollow shaft and that is both simple in construction and capable of a range of uses, it is proposed according to the invention that at least one cam that reduces the inside diameter of the hollow shaft should be positioned on the interior of the hollow shaft.

公开(公告)号：US09042732B2

公开(公告)日：2015-05-26

申请号：US13785603

申请日：2013-03-05

申请人： William Patrick Cune ,  Michael Sauer ,  Wolfgang Gottfried Tobias Schweiker

发明人： William Patrick Cune ,  Michael Sauer ,  Wolfgang Gottfried Tobias Schweiker

IPC分类号： H04B10/2575 ,  H04J14/02

CPC分类号： H04B10/25753 ,  H04B10/25752 ,  H04J1/08 ,  H04J14/02 ,  H04J14/0282 ,  H04J14/0298 ,  H04Q11/0067 ,  H04Q2011/0016

摘要： Optical fiber-based distributed communications systems that provide and support both RF communication services and digital data services are disclosed herein. The RF communication services and digital data services can be distributed over optical fiber to client devices, such as remote antenna units for example. In certain embodiments, digital data services can be distributed over optical fiber separate from optical fiber distributing RF communication services. In other embodiments, digital data services can be distributed over common optical fiber with RF communication services. For example, digital data services can be distributed over common optical fiber with RF communication services at different wavelengths through wavelength-division multiplexing (WDM) and/or at different frequencies through frequency-division multiplexing (FDM). Power distributed in the optical fiber-based distributed communications system to provide power to remote antenna units can also be accessed to provide power to digital data service components.

摘要翻译： 本文公开了提供和支持RF通信服务和数字数据服务的基于光纤的分布式通信系统。 RF通信服务和数字数据服务可以通过光纤分发到客户端设备，例如远程天线单元。 在某些实施例中，数字数据业务可以分布在与分配RF通信服务的光纤分开的光纤上。 在其他实施例中，数字数据服务可以通过具有RF通信服务的普通光纤分布。 例如，数字数据业务可以通过波分复用（WDM）和/或通过频分复用（FDM）在不同频率的RF通信服务以不同波长分布在普通光纤上。 分布在基于光纤的分布式通信系统中的功率为远程天线单元提供电力也可以被访问以向数字数据服务组件提供电力。

公开(公告)号：USD717432S1

公开(公告)日：2014-11-11

申请号：US29439537

申请日：2012-12-12

申请人： Joel Leroy ,  Michael Sauer ,  Sebastian Wagner ,  Thomas Weishaupt ,  Daniela Wiest

设计人： Joel Leroy ,  Michael Sauer ,  Sebastian Wagner ,  Thomas Weishaupt ,  Daniela Wiest

公开(公告)号：USD713033S1

公开(公告)日：2014-09-09

申请号：US29401033

申请日：2011-09-06

申请人： Michael Sauer ,  Felix Lindner

设计人： Michael Sauer ,  Felix Lindner

公开(公告)号：US08814886B2

公开(公告)日：2014-08-26

申请号：US12398244

申请日：2009-03-05

申请人： Sascha Berberich ,  Martin Oberlaender ,  Michael Sauer

发明人： Sascha Berberich ,  Martin Oberlaender ,  Michael Sauer

IPC分类号： A61B17/04 ,  A61B17/22

CPC分类号： A61B17/0483 ,  A61B2017/06009 ,  A61B2017/06042

摘要： A thread catcher for surgical sewing material consisting of a handle, a hollow shaft positioned on the distal side of the handle, and a catching device that is mounted so that it can be slid lengthwise within the hollow shaft by means of a drive element and whose distal end, which can slide out of the distal end of the hollow shaft, is configured as a catcher loop. To create a thread catcher for surgical sewing material that is simple to operate and ensures rapid and secure grasping of the surgical sewing material, it is proposed with the invention that the catcher loop should consist of at least three segments that are distally connected with one another.

摘要翻译： 一种用于手术缝合材料的线捕获器，其由手柄，位于手柄的远侧侧的空心轴和捕获装置构成，该捕获装置安装成使得其可以通过驱动元件在空心轴内纵向滑动， 远端可以从空心轴的远端滑出，被构造成捕获环。 为了创建手术缝纫材料的线捕获器，其操作简单并且确保手术缝合材料的快速和可靠的抓握，本发明提出捕获器回路应由彼此远端连接的至少三个段组成 。

公开(公告)号：US08649684B2

公开(公告)日：2014-02-11

申请号：US13194429

申请日：2011-07-29

申请人： Raymond A. Casterline ,  Gary L. Coakley ,  Vladimir M. Cotfas ,  Eric M. Sadowski ,  Michael Sauer ,  Dale A. Webb ,  Steven C. Kapp ,  Rajeshkannan Palanisamy ,  David R. Peters ,  Michael B. Webb

发明人： Raymond A. Casterline ,  Gary L. Coakley ,  Vladimir M. Cotfas ,  Eric M. Sadowski ,  Michael Sauer ,  Dale A. Webb ,  Steven C. Kapp ,  Rajeshkannan Palanisamy ,  David R. Peters ,  Michael B. Webb

IPC分类号： H04B10/00

CPC分类号： H04B10/25753 ,  H04B10/0795 ,  H04B10/25754 ,  H04B10/25756

摘要： Optical fiber-based wireless systems and related components and methods are disclosed. The systems support radio frequency (RF) communications with clients over optical fiber, including Radio-over-Fiber (RoF) communications. The systems may be provided as part of an indoor distributed antenna system (IDAS) to provide wireless communication services to clients inside a building or other facility. The communications can be distributed between a head end unit (HEU) that receives carrier signals from one or more service or carrier providers and converts the signals to RoF signals for distribution over optical fibers to end points, which may be remote antenna units (RAUs). A microprocessor-based control system or systems may also be employed. The control systems may include one or more microprocessors or microcontrollers in one or more of the components of the system that execute software instructions to control the various components and provide various features for the optical fiber-based distributed antenna systems.

摘要翻译： 公开了基于光纤的无线系统及相关组件和方法。 该系统通过光纤支持与客户端的射频（RF）通信，包括无线光纤（RoF）通信。 该系统可以作为室内分布式天线系统（IDAS）的一部分提供，以向建筑物或其他设施内的客户提供无线通信服务。 通信可以分配在从一个或多个服务或运营商提供商接收载波信号的头端单元（HEU）之间，并将信号转换成RoF信号，以通过光纤分配到端点，终端可以是远程天线单元（RAU） 。 还可以采用基于微处理器的控制系统或系统。 控制系统可以包括系统的一个或多个组件中的一个或多个微处理器或微控制器，其执行软件指令以控制各种组件并为基于光纤的分布式天线系统提供各种特征。

公开(公告)号：USD692133S1

公开(公告)日：2013-10-22

申请号：US29416274

申请日：2012-03-20

申请人： Matthias Steinwachs ,  Sascha Berberich ,  Bodo Kreidler ,  Michael Sauer ,  Sabine Zahler

设计人： Matthias Steinwachs ,  Sascha Berberich ,  Bodo Kreidler ,  Michael Sauer ,  Sabine Zahler