公开(公告)号：US4838862A

公开(公告)日：1989-06-13

申请号：US892991

申请日：1986-08-04

申请人： Richard Baker ,  Verne Helm ,  Paul Shrock

发明人： Richard Baker ,  Verne Helm ,  Paul Shrock

IPC分类号： A61M37/00 ,  A61K9/22 ,  A61M5/142 ,  A61M5/145

CPC分类号： A61M5/145 ,  A61M2005/14513 ,  A61M5/14248

摘要： A portable controlled release osmotic infusion device, which can be activated on demand by the user, comprising a rigid housing containing:a. a fluid-imbibing assembly, comprising a solvent-containing chamber and a solute-containing chamber; the two chambers separated by a rigid semipermeable membrane covered by a thin taut foil seal,b. a drug-containing chamber separated from the fluid-imbibing assembly by a leakproof impermeable elastic diaphragm, which expands into the drug-containing chamber in use and drives the drug through a dispersing orifice at a steady rate, andc. an activating device which ruptures the foil seal described in (a) above and initiates the osmotic action of the device.The osmotic device is filled with drug in solution or suspended form during manufacture and can be stored without deterioration of the contents for prolonged periods of time.